
Essential Concepts in Molecular Pathology
Resources
Description
Key Features
- Offers an essential introduction to molecular genetics and the "molecular" aspects of human disease
- Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
- In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology.
- "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.
- Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
- Each chapter ends with Key Summary Points and Suggested Readings
Readership
Graduate students in allied health programs, medical students, undergraduate students; pathology residents and other postdoctoral residents and fellows interested in the molecular mechanisms of disease.
Table of Contents
PART I Essential Pathology - Mechanisms of Disease
Chapter 1 Cell Injury, Cell Death, and Cellular Adaptation
John J. Lemasters, M.D., Ph.D.
Chapter 2 Acute and Chronic Inflammation
Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.
Chapter 3 Infection and Host Response
Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.
Chapter 4 Neoplasia
William B. Coleman, Ph.D., and Tara Rubinas, M.D.
PART II Concepts in Molecular Biology and Genetics
Chapter 5 Basic Concepts in Human Molecular Genetics
W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.
Chapter 6 The Human Genome: Implications for the Understanding of Human Disease
William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.
Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease
Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.
Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease
Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.
Chapter 9 The Human Proteome: Implications for the Understanding of Human Disease
Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin
Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease
M. Michael Barmada, Ph.D. and David C. Whitcomb
PART III Principles and Practice of Molecular Pathology
Chapter 11 Pathology: The Clinical Description of Human Disease
William K. Funkhouser, M.D., Ph.D.
Chapter 12 Molecular Pathogenesis: The Biological Basis of Human Disease
William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D.
Chapter 13 Integration of Molecular and Cellular Pathogenesis
Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D.
PART IV Molecular Pathology of Human Disease
Chapter 14 Molecular Basis of Cardiovascular Disease
Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu
Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases
Nigel S. Key, M.D., and Alice Ma, M.D.
Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases
Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D.
Chapter 17 Molecular Basis of Diseases of Immunity
David O. Beenhouwer, Ph.D.
Chapter 18 Molecular Basis of Pulmonary Disease
Dani S. Zander, M.D., and Carol Farver, M.D.
Chapter
Chapter 19 Molecular Basis of Diseases of the Gastrointestinal TractAntonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.
Chapter 20 Molecular Basis of Liver Disease
Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.
Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas
Markus M. Lerch, M.D.
Chapter 22 Molecular Basis of Diseases of the Endocrine System
Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D.
Chapter 23 Molecular Basis of Gynecologic Diseases
Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.
Chapter 24 Molecular Pathogenesis of Diseases of the Kidney
Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.
Chapter 25 Molecular Basis of Prostate Disease
William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.
Chapter 26 Molecular Basis of Breast Disease
Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard
Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium
Chapter 27 Molecular Basis of Skin Disease
John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D.
Chapter 28 Molecular Basis of Diseases of the Nervous System
Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.
PART V Practice of Molecular Medicine
Chapter 29 Molecular Diagnosis of Human Disease
Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D.
Chapter 30 Molecular Assessment of Human Disease in the Clinical Laboratory
Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.
Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.
Product details
- No. of pages: 462
- Language: English
- Copyright: © Academic Press 2010
- Published: February 9, 2010
- Imprint: Academic Press
- Hardcover ISBN: 9780123744180
- eBook ISBN: 9780080922188
About the Editors
William Coleman
Affiliations and Expertise
Gregory Tsongalis
Affiliations and Expertise
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