Essential Concepts in Molecular Pathology

1st Edition

Editors: William Coleman Gregory Tsongalis
Hardcover ISBN: 9780123744180
eBook ISBN: 9780080922188
Imprint: Academic Press
Published Date: 9th February 2010
Page Count: 462
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This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.

Key Features

  • Offers an essential introduction to molecular genetics and the "molecular" aspects of human disease
  • Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
  • In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology.
  • "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.
  • Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
  • Student web site hosts "self-assessment" questions; Professor web site hosts all figures from book
  • Each chapter ends with Key Summary Points and Suggested Readings



    Graduate students in allied health programs, medical students, undergraduate students; pathology residents and other postdoctoral residents and fellows interested in the molecular mechanisms of disease.

    Table of Contents

    PART I Essential Pathology - Mechanisms of Disease

    Chapter 1 Cell Injury, Cell Death, and Cellular Adaptation

    John J. Lemasters, M.D., Ph.D.


    Chapter 2 Acute and Chronic Inflammation

    Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.

    Chapter 3 Infection and Host Response

    Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.


    Chapter 4 Neoplasia

    William B. Coleman, Ph.D., and Tara Rubinas, M.D.

    PART II Concepts in Molecular Biology and Genetics

    Chapter 5 Basic Concepts in Human Molecular Genetics

    W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.

    Chapter 6 The Human Genome: Implications for the Understanding of Human Disease

    William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.

    Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease

    Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.


    Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease

    Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.

    Chapter 9 The Human Proteome: Implications for the Understanding of Human Disease

    Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin

    Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease

    M. Michael Barmada, Ph.D. and David C. Whitcomb


    PART III Principles and Practice of Molecular Pathology

    Chapter 11 Pathology: The Clinical Description of Human Disease

    William K. Funkhouser, M.D., Ph.D.

    Chapter 12 Molecular Pathogenesis: The Biological Basis of Human D


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    Academic Press
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    About the Editor

    William Coleman

    William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine and Director of Graduate Studies for the Molecular and Cellular Pathology Graduate Program at the University of North Carolina School of Medicine (Chapel Hill, NC). Dr. Coleman is co-director of the UNC Program in Translational Medicine, and co-director of the Environmental Pathology Predoctoral and Postdoctoral Training Program. In addition, he is affiliated with the Curriculum in Toxicology and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a three-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves on the editorial boards of Clinica Chimica Acta, The American Journal of Pathology, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, and Laboratory Investigation, and has served as an ad hoc reviewer for 48 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 100 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored six books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer.

    Affiliations and Expertise

    Professor, Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    Gregory Tsongalis

    Dr. Tsongalis’s research interests are in the pathogenesis of solid tumors, disease association of SNP genotyping and personalized medicine. He has authored/edited eight textbooks in the field of molecular pathology, published more than 170 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. Dr. Tsongalis has been the recipient of numerous investigator/scientist awards. He is on the editorial board of 9 journals including Clinical Chemistry, the Journal of Molecular Diagnostics and Clinical Chemistry and Laboratory Medicine.

    Affiliations and Expertise

    Professor of Pathology, Director, Molecular Pathology, and Co-Director Translational Research Program, Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA