Essential Concepts in Molecular Pathology - 1st Edition - ISBN: 9780123744180, 9780080922188

Essential Concepts in Molecular Pathology

1st Edition

Editors: William Coleman Gregory Tsongalis
eBook ISBN: 9780080922188
Hardcover ISBN: 9780123744180
Imprint: Academic Press
Published Date: 9th February 2010
Page Count: 462
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Description

This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.

Key Features

  • Offers an essential introduction to molecular genetics and the "molecular" aspects of human disease
  • Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
  • In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology.
  • "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.
  • Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
  • Each chapter ends with Key Summary Points and Suggested Readings

Readership

Graduate students in allied health programs, medical students, undergraduate students; pathology residents and other postdoctoral residents and fellows interested in the molecular mechanisms of disease.

Table of Contents

PART I Essential Pathology - Mechanisms of Disease

Chapter 1 Cell Injury, Cell Death, and Cellular Adaptation

John J. Lemasters, M.D., Ph.D.

 

Chapter 2 Acute and Chronic Inflammation

Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.

Chapter 3 Infection and Host Response

Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.

 

Chapter 4 Neoplasia

William B. Coleman, Ph.D., and Tara Rubinas, M.D.

PART II Concepts in Molecular Biology and Genetics

Chapter 5 Basic Concepts in Human Molecular Genetics

W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.

Chapter 6 The Human Genome: Implications for the Understanding of Human Disease

William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.

Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease

Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.

 

Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease

Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.

Chapter 9 The Human Proteome: Implications for the Understanding of Human Disease

Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin

Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease

M. Michael Barmada, Ph.D. and David C. Whitcomb

 

PART III Principles and Practice of Molecular Pathology

Chapter 11 Pathology: The Clinical Description of Human Disease

William K. Funkhouser, M.D., Ph.D.

Chapter 12 Molecular Pathogenesis: The Biological Basis of Human Disease

William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D.

Chapter 13 Integration of Molecular and Cellular Pathogenesis

Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D.

 

PART IV Molecular Pathology of Human Disease

Chapter 14 Molecular Basis of Cardiovascular Disease

Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu

 

Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases

Nigel S. Key, M.D., and Alice Ma, M.D.

Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases

Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D.

 

Chapter 17 Molecular Basis of Diseases of Immunity

David O. Beenhouwer, Ph.D.

Chapter 18 Molecular Basis of Pulmonary Disease

Dani S. Zander, M.D., and Carol Farver, M.D.

Chapter

Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract

Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.

 

Chapter 20 Molecular Basis of Liver Disease

Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.

Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas

Markus M. Lerch, M.D.

Chapter 22 Molecular Basis of Diseases of the Endocrine System

Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D.

Chapter 23 Molecular Basis of Gynecologic Diseases

Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.

Chapter 24 Molecular Pathogenesis of Diseases of the Kidney

Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.

Chapter 25 Molecular Basis of Prostate Disease

William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.

Chapter 26 Molecular Basis of Breast Disease

Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard

Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium

Chapter 27 Molecular Basis of Skin Disease

John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D.

Chapter 28 Molecular Basis of Diseases of the Nervous System

Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.

 

PART V Practice of Molecular Medicine

Chapter 29 Molecular Diagnosis of Human Disease

Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D.

 

Chapter 30 Molecular Assessment of Human Disease in the Clinical Laboratory

Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.

Chapter 31 Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease

Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.

Details

No. of pages:
462
Language:
English
Copyright:
© Academic Press 2010
Published:
Imprint:
Academic Press
eBook ISBN:
9780080922188
Hardcover ISBN:
9780123744180

About the Editor

William Coleman

William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine at the University of North Carolina School of Medicine (Chapel Hill, NC), and Director of the UNC Program in Translational Medicine. In addition, he is affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves as an associate editor for The American Journal of Pathology, BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 95 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 125 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored eight books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Affiliations and Expertise Professor, Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, UNC Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

Affiliations and Expertise

PhD, Professor, Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

Gregory Tsongalis

Greg Tsongalis is the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH and a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH. He is a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 200 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the AACC, ASIP, FASEB and AMP where he is a past President. He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalyts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. He also serves on numerous corporate scientific advisory boards.

Affiliations and Expertise

PhD, Professor of Pathology and Laboratory Medicine, Director of Laboratory for Clinical Genomics and Advanced Technology (CGAT), Audrey and Theodor Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH, USA