This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.
- Offers an essential introduction to molecular genetics and the "molecular" aspects of human disease
- Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
- In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology.
- "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.
- Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
- Each chapter ends with Key Summary Points and Suggested Readings
Graduate students in allied health programs, medical students, undergraduate students; pathology residents and other postdoctoral residents and fellows interested in the molecular mechanisms of disease.
PART I Essential Pathology - Mechanisms of Disease
Chapter 1 Cell Injury, Cell Death, and Cellular Adaptation
John J. Lemasters, M.D., Ph.D.
Chapter 2 Acute and Chronic Inflammation
Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.
Chapter 3 Infection and Host Response
Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.
Chapter 4 Neoplasia
William B. Coleman, Ph.D., and Tara Rubinas, M.D.
PART II Concepts in Molecular Biology and Genetics
Chapter 5 Basic Concepts in Human Molecular Genetics
W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.
Chapter 6 The Human Genome: Implications for the Understanding of Human Disease
William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.
Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease
Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.
Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease
Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.
Chapter 9 The Human Proteome: Implications for the Understanding of Human Disease
Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin
Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease
M. Michael Barmada, Ph.D. and David C. Whitcomb
PART III Principles and Practice of Molecular Pathology
Chapter 11 Pathology: The Clinical Description of Human Disease
William K. Funkhouser, M.D., Ph.D.
Chapter 12 Molecular Pathogenesis: The Biological Basis of Human Disease
William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D.
Chapter 13 Integration of Molecular and Cellular Pathogenesis
Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D.
PART IV Molecular Pathology of Human Disease
Chapter 14 Molecular Basis of Cardiovascular Disease
Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu
Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases
Nigel S. Key, M.D., and Alice Ma, M.D.
Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases
Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D.
Chapter 17 Molecular Basis of Diseases of Immunity
David O. Beenhouwer, Ph.D.
Chapter 18 Molecular Basis of Pulmonary Disease
Dani S. Zander, M.D., and Carol Farver, M.D.
ChapterChapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract
Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.
Chapter 20 Molecular Basis of Liver Disease
Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.
Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas
Markus M. Lerch, M.D.
Chapter 22 Molecular Basis of Diseases of the Endocrine System
Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D.
Chapter 23 Molecular Basis of Gynecologic Diseases
Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.
Chapter 24 Molecular Pathogenesis of Diseases of the Kidney
Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.
Chapter 25 Molecular Basis of Prostate Disease
William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.
Chapter 26 Molecular Basis of Breast Disease
Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard
Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium
Chapter 27 Molecular Basis of Skin Disease
John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D.
Chapter 28 Molecular Basis of Diseases of the Nervous System
Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.
PART V Practice of Molecular Medicine
Chapter 29 Molecular Diagnosis of Human Disease
Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D.
Chapter 30 Molecular Assessment of Human Disease in the Clinical Laboratory
Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.
Chapter 31 Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease
Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.
- No. of pages:
- © Academic Press 2010
- 9th February 2010
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine at the University of North Carolina School of Medicine (Chapel Hill, NC), and Director of the UNC Program in Translational Medicine. In addition, he is affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves as an associate editor for The American Journal of Pathology, BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 95 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 125 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored eight books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Affiliations and Expertise Professor, Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, UNC Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA
PhD, Professor, Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Greg Tsongalis is the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH and a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH. He is a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 200 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the AACC, ASIP, FASEB and AMP where he is a past President. He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalyts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. He also serves on numerous corporate scientific advisory boards.
PhD, Professor of Pathology and Laboratory Medicine, Director of Laboratory for Clinical Genomics and Advanced Technology (CGAT), Audrey and Theodor Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH, USA