Essential Concepts in Molecular Pathology

Essential Concepts in Molecular Pathology

1st Edition - February 9, 2010

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  • Editors: William Coleman, Gregory Tsongalis
  • Hardcover ISBN: 9780123744180
  • eBook ISBN: 9780080922188

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Description

This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.

Key Features

  • Offers an essential introduction to molecular genetics and the "molecular" aspects of human disease
  • Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
  • In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology.
  • "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.
  • Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
  • Each chapter ends with Key Summary Points and Suggested Readings

Readership

Graduate students in allied health programs, medical students, undergraduate students; pathology residents and other postdoctoral residents and fellows interested in the molecular mechanisms of disease.

Table of Contents

  • PART I Essential Pathology - Mechanisms of Disease

    Chapter 1 Cell Injury, Cell Death, and Cellular Adaptation

    John J. Lemasters, M.D., Ph.D.

     

    Chapter 2 Acute and Chronic Inflammation

    Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.

    Chapter 3 Infection and Host Response

    Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.

     

    Chapter 4 Neoplasia

    William B. Coleman, Ph.D., and Tara Rubinas, M.D.

    PART II Concepts in Molecular Biology and Genetics

    Chapter 5 Basic Concepts in Human Molecular Genetics

    W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.

    Chapter 6 The Human Genome: Implications for the Understanding of Human Disease

    William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.

    Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease

    Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.

     

    Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease

    Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.

    Chapter 9 The Human Proteome: Implications for the Understanding of Human Disease

    Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin

    Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease

    M. Michael Barmada, Ph.D. and David C. Whitcomb

     

    PART III Principles and Practice of Molecular Pathology

    Chapter 11 Pathology: The Clinical Description of Human Disease

    William K. Funkhouser, M.D., Ph.D.

    Chapter 12 Molecular Pathogenesis: The Biological Basis of Human Disease

    William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D.

    Chapter 13 Integration of Molecular and Cellular Pathogenesis

    Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D.

     

    PART IV Molecular Pathology of Human Disease

    Chapter 14 Molecular Basis of Cardiovascular Disease

    Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu

     

    Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases

    Nigel S. Key, M.D., and Alice Ma, M.D.

    Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases

    Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D.

     

    Chapter 17 Molecular Basis of Diseases of Immunity

    David O. Beenhouwer, Ph.D.

    Chapter 18 Molecular Basis of Pulmonary Disease

    Dani S. Zander, M.D., and Carol Farver, M.D.

    Chapter

    Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract

    Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.

     

    Chapter 20 Molecular Basis of Liver Disease

    Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.

    Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas

    Markus M. Lerch, M.D.

    Chapter 22 Molecular Basis of Diseases of the Endocrine System

    Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D.

    Chapter 23 Molecular Basis of Gynecologic Diseases

    Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.

    Chapter 24 Molecular Pathogenesis of Diseases of the Kidney

    Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.

    Chapter 25 Molecular Basis of Prostate Disease

    William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.

    Chapter 26 Molecular Basis of Breast Disease

    Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard

    Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium

    Chapter 27 Molecular Basis of Skin Disease

    John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D.

    Chapter 28 Molecular Basis of Diseases of the Nervous System

    Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.

     

    PART V Practice of Molecular Medicine

    Chapter 29 Molecular Diagnosis of Human Disease

    Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D.

     

    Chapter 30 Molecular Assessment of Human Disease in the Clinical Laboratory

    Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.

    Chapter 31 Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease

    Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.

Product details

  • No. of pages: 462
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: February 9, 2010
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123744180
  • eBook ISBN: 9780080922188

About the Editors

William Coleman

William B. Coleman, PhD is the Executive Officer for the American Society for Investigative Pathology (Rockville, MD). Prior to taking this position with the American Society for Investigative Pathology, Dr. Coleman spent 28 years at the University of North Carolina School of Medicine (Chapel Hill, NC), first as a postdoctoral fellow (1990-1995) and then as a faculty member (1995-2018) in the Department of Pathology and Laboratory Medicine. During his time at the UNC School of Medicine, Dr. Coleman served as Director of Graduate Studies for the Molecular and Cellular Pathology Ph.D. Program (2006-2012; now the Pathobiology and Translational Medicine Ph.D. Program), was a co-founder of the UNC Program in Translational Medicine and served as its Co-Director (2006-2015) and then its Director (2015-2018), was affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and was a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman was active in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at the UNC School of Medicine. Prior to becoming an employee, Dr. Coleman was active in the leadership of the American Society for Investigative Pathology, serving in various roles including President (2015-2016). Dr. Coleman was honored with the ASIP Outstanding Investigator Award in 2013 from the American Society for Investigative Pathology. He is also a long-time member of the American Association for Cancer Research. He serves as Senior Associate Editor for The American Journal of Pathology, and is an Associate Editor for BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 99 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research was funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 140 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored ten books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer.

Affiliations and Expertise

Executive Officer, American Society for Investigative Pathology, Rockville, MD, USA

Gregory Tsongalis

Gregory J. Tsongalis, PhD, HCLD, CC, FNACB., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards.

Affiliations and Expertise

Professor, Vice Chair for Research, and Director of the Laboratory for Clinical Genomics and Advanced Technologies, Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Health System and the Audrey and Theodor Geisel School of Medicine, Lebanon, NH, USA

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