Description

Need a tested, reliable method that works? Put Essential Bioimaging Methods to work for you. Editor Michael Conn has hand-picked the most robust methods from his previously-published volumes in the Methods in Enzymology series. Many of these methods have been briefly updated by the authors that created them and use them in their research, and this book further refines and organizes existing content and focuses on methods that work, including MRI, fMRI, PET, Microscopic optical imaging and other. Part of the Reliable Lab Solution series, this volume provides clear advice and explicit protocols, providing updates to classic, tried-and-true methods and an essential addition to the bookshelf or workbench of any researcher in the field.

Key Features

    * Highlights usefulness of techniques in basic research detailing MRI imaging of small animals, fMRI of Macaque monkeys, and baboon model of reperfused stroke
    * Built from volumes in the flagship brand, Methods in Enzymology
    * Provides tricks, tips and different approaches

    Readership

    Researchers and students in biochemistry, cell biology, molecular biology, and neuroimaging

    Table of Contents

    I. Imaging in Animal and Human Models
    1. Positron Emission Tomography: An Advanced Nuclear Medicine Imaging Technique from Research To Clinical Rakesh Kumar, Suman Jana
    2. Biophysical Basis of Animal Magnetic Resonance Imaging of Small Animals (Bruce M. Damon, John C. Gore)
    3. Functional Magnetic Resonance Imaging of Macaque Monkeys (Kiyoshi Nakahara)
    4. Atlas Template Images for NHP Neuroimaging: Baboon and Macaque (Kevin Black)
    5. MRI of Brain Function (Stuart Clare)
    II. Imaging of Receptors, Small Molecules, and Protein-Protein Interactions
    6. PET Receptor Assay With Multiple Ligand Concentrations: An Equilibrium Approach (James E. Holden, Doris J. Doudet)
    7. Estimation Of Local Receptor Density B’(Max) And Other Parameter Via Multiple-Injection PET Experiments (Evan Morris)
    8. Magnetic Resonance Imaging In Biomedical Research: Imaging Of Drugs And Drug Effects (Markus Rudin, Nicolau Beckmann, Martin Rausch)
    9. Imaging Myocardium Enzymatic Pathways With Carbon-11 Radiotracers (Carmen S. Dence, Pilar Herrero, Sally W. Schwarz, Robert H. Mach, Robert J. Gropler, Michael J. Welch)
    III. Disease Models
    10. Molecular And Functional Imaging of Cancer: Advances In MRI And MRS (Arvind P. Pathak, Barjor Gimi, Kristine Glunde, Ellen Ackerstaff, Dmitri Artemov, Zaver M. Bhujwalla)
    11. A Modified Transorbital Baboon Model of Reperfused Stroke (Anthony L. D’Ambrosio, Michael E. Sughrue, J. Mocco, William J. Mack, Ryan G. King, Shivani Agarwal, E. Sander Connolly, Jr.)
    12. Structural And Functional Optical Imaging of Angiogenesis In Animal Models (Richard L. Roberts, Pengnian Charles Lin)
    13. MRI of Animal Models of Brain Disease (Louise van der Weerd, David L. Thomas, John S. Thornton, Mark F. Lythgoe)
    14. Magnetic Resonance Imaging in Animal Models of Pathologies (Pasquina Marzola, Andrea Sbarbati)
    15. Application Of Combined Magnetic Resonance Imaging, Histopathologic And Function Studies For Evaluation Of Aminogua

    Details

    No. of pages:
    450
    Language:
    English
    Copyright:
    © 2009
    Published:
    Imprint:
    Academic Press
    Print ISBN:
    9780123750433
    Electronic ISBN:
    9780080963426

    About the editor

    P. Michael Conn

    P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn serve