Essays in Toxicology

Essays in Toxicology

Volume 7

1st Edition - January 1, 1976

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  • Editor: Wayland J. Hayes
  • eBook ISBN: 9781483216478

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Essays in Toxicology, Volume 7 presents essays on toxicology and related topics. The book presents essays on the effects of toxicants on reproductive performance; an overall view of carcinogenesis from an epidemiological viewpoint and the potentialities and limitations of the epidemiological method in cancer control; and the activity of cytochrome P450 and mixed-function oxidase in target and nontarget organisms. The text also includes essays on the toxicity of hexachlorophene and the use of hexachlorophene as an antibacterial agent; the methodology, dose measurement, and respiratory function assessment in respiratory toxicology; as well as behavioral toxicology, with focus on early warning and worker safety and health. Pharmacologists, biochemists, pathologists, neurophysiologists, epidemiologists, and toxicologists will find the book invaluable.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    1. EfEects of Toxicants on Reproductive Performance

    I. Introduction

    II. DDT: Mythical Mutagen

    III. Chemical Mutagens: The Real Thing

    IV. Anti metabolites

    V. Mitotic Spindle Poisons

    VI. Somatic Aspects

    VII. Concluding Remarks


    2. Chronic Toxicology — An Epidemiologist's Approach to the Problem of Carcinogenesis

    I. Introduction

    II. General Principles of Epidemiological Studies in Human Carcinogenesis

    III. Etiological Approaches to Human Cancer Based on Geographical Variations in Cancer Incidence

    IV. Epidemiological Studies Related to Unusual Exposure to Potential Carcinogens

    V. Conclusion



    3. Comparative Toxicology: Cytochrome P 450 and Mixed-Function Oxidase Activity in Target and Nontarget Organisms

    I. Introduction

    II. General Features of Cytochrome P 450 and the Microsomal Mixed-Function Oxidase System of Importance in Comparative Investigations

    III. Relationship of Spectrum Formation to Sustrate Activity

    IV. Intracellular Location of Cytochrome P 450

    V. Occurrence of Cytochrome P 450

    VI. Evolutionary Considerations

    VII. Role of Cytochrome P 450 in Resistance to Insecticides

    VIII. Conclusions


    4. Hexachlorophene: Toxicity and Use as an Antibacterial Agent

    I. Introductory Remarks

    II. Staphylococcus Infections in Infants and Use of Hexachlorophene on Infants and Other Segments of the General Population

    III. Toxicity of Hexachlorophene in Animals

    IV. Human Toxicity

    V. Skin Absorption, Hexachlorophene Blood Levels, and Tissue Levels

    VI. Other Toxic Effects of Hexachlorophene

    VII. Legal Restrictions of Hexachlorophene


    5. Respiratory Toxicology

    I. Introduction

    II. Methodology

    III. Estimation of Dose

    IV. Respiratory Function Tests

    V. Concluding Remarks


    6. Behavioral Toxicology: Early Warning and Worker Safety and Health

    I. Introduction

    II. Historical Development of Behavioral Toxicology

    III. Behavioral Toxicology of Industrial Chemicals

    IV. Chemical Interactions

    V. Drug Effects and Industrial Safety

    VI. Methodological Problems in Behavioral Toxicology Research

    VII. Future of Behavioral Toxicoloy Research

    Subject Index

Product details

  • No. of pages: 222
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 1, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9781483216478

About the Editor

Wayland J. Hayes

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