Erectile Dysfunction as a Cardiovascular Impairment organizes and summarizes the many aspects of biology and metabolism in cardiovascular and sexual function. Coverage includes how blood vessels are discovered to work, their role in hypertension, atherosclerosis, type-2 diabetes, oxidative stress, metabolic syndrome, and erectile dysfunction.

Key Features

  • Unifies medical disorders linked to cardiovascular and heart disease as endothelium impairment, to which
    vasculogenic erectile dysfunction is now added and given equal rank for the first time
  • Presents hypertension, atherosclerosis, metabolic syndrome, and erectile dysfunction as symptoms of disease
  • Offers clinical research on vasculogenic erectile dysfunction predicting onset and severity of heart disease.



Researchers and clinicians working in cardiology.

Table of Contents







Chapter 1. Introduction

1.1 Erectile Dysfunction—as Presently Defined

1.2 The Aim and Scope of this Monograph

1.3 The Prevalence of Erectile Dysfunction

1.4 It is more complicated than the Standard American Diet

1.5 The Standard American Diet

1.6 An Important Note to the Reader

1.7 What Impairs Sexual Vitality?

1.8 Sexual Arousal and “Performance”

1.9 Erectile Dysfunction and Cardiovascular Disease

1.10 Erectile Dysfunction and Heart Disease

1.11 “Hypertension is Associated with Severe Erectile Dysfunction”

1.12 Erectile Dysfunction is Linked to Elevated Cholesterol and Coronary Heart Disease Risk

1.13 It’s also about Quality of Life

1.14 Declining Sexual Desire vs. Declining Performance

1.15 Diurnal Variation

1.16 The Acetylcholine/Nitric Oxide/Cyclic Guanosine Monophosphate Pathway

1.17 A Footnote to History

1.18 The Endothelium—the First Vascular Control Signal System

1.19 Vessels of the Vessels—Vasa Vasorum

1.20 Vasa Vasorum Depends Exclusively on Endothelium-Derived Vasorelaxation

1.21 The Penis

1.22 The Pathway to Penile Erection

1.23 Phosphodiesterase Type-5—Friend or Foe?

1.24 Cardiovascular Dysfunction and Sexual Dysfunction in Aging

1.25 Note on Terminology


Chapter 2. Measuring and Evaluating Function, Impairment, and Change with Intervention

2.1 Introduction

2.2 When Do We Know that We “Know” in Biological Science?

2.3 The Clinical Trial (or Clinical Study)

2.4 Note on Form of Citation

2.5 Note on Validity of Research Reports

2.6 Statistics Simplified

2.7 Hypertension

2.8 H


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© 2014
Academic Press
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About the author

Robert Fried

Emeritus Professor, Doctoral Faculty of Behavioral Neuroscience, City University of New York (CUNY), New York, NY. Member American Physiology Society (APS) (Cardiovascular and Respiration division). Formerly, Director of the Rehabilitation Research Institute (RRI), International Center for the Disabled (ICD), New York, NY. Diplomate in Behavioral Medicine, International Academy of Behavioral Medicine, Counseling and Psychotherapy (IABMCP). Fellow, New York Academy of Sciences (NYAS).