Equine Genetic Diseases, An Issue of Veterinary Clinics of North America: Equine Practice

1st Edition, Volume 36-2 - July 19, 2020
Editor: Carrie Finno
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 0 8 5 9 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 0 8 6 0 - 9

This issue of Veterinary Clinics: Equine Practice, guest edited by Dr. Carrie Finno, focuses on Equine Genetic Diseases. Topics include: Genetics, Genomics, and Emergent Precision… Read more

Equine Genetic Diseases, An Issue of Veterinary Clinics of North America: Equine Practice

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This issue of Veterinary Clinics: Equine Practice, guest edited by Dr. Carrie Finno, focuses on Equine Genetic Diseases. Topics include: Genetics, Genomics, and Emergent Precision Medicine 12 years post Equine Reference Genome; Equine SNP Genotyping Arrays; Next-generation Sequencing; Genetic Testing in the Horse; Genetics of Cardiovascular Disease; Genetics of Respiratory Disease; Genetics of Neurological Disease; Genetics of Immune Disease; Genetics of Orthopedic Disease; Genetics of Ocular Disease; Genetics of Skin Disease; Genetics of Endocrine and Metabolic Disease; Genetics of Muscle Disease; Genetics of Laminitis; Genetics of Reproductive Diseases; and Genetics of Behavioral Traits.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Genetics, Genomics, and Emergent Precision Medicine 12 Years After the Equine Reference Genome Was Published
Key points
What is a reference genome?
What is annotation?
Paradigm shift in research
Crystal ball gazing
Equine Genotyping Arrays
Key points
Introduction
Design and implementation of equine genotyping arrays
Usefulness in association mapping
Population genomics
Imputation
Forward compatibility with EquCab3.0
Next-Generation Sequencing in Equine Genomics
Key points
Introduction
Building genomic resources for the horse
Technology
Sequencing platforms
Sequence reads
Applications
Data generation and handling
Validation of results
Future directions
Genetic Testing in the Horse
Key points
Introduction and history of equine genetic testing
Genetic testing for parentage and identity
Genetic tests for coat color and associated disorders
Genetic testing for genetic diseases
Genetic testing for performance traits
Standardization for diagnostic tests
Future developments in equine genetic testing
Unraveling the Genetics Behind Equid Cardiac Disease
Key points
Introduction
Summary
Genetics of Equine Respiratory Disease
Key points
Introduction
Tympany of the guttural pouches
Recurrent laryngeal neuropathy
Miscellaneous upper airway disorders
Equine asthma
Exercise-induced pulmonary hemorrhage
Infectious diseases of the respiratory tract
Summary
Genetics of Equine Neurologic Disease
Key points
Introduction
Neurologic disorders with known mutations
Summary
Genetics of Immune Disease in the Horse
Key points
Introduction and scope
Summary
Genetics of Equine Orthopedic Disease
Key points
Introduction
Osteochondrosis
Degenerative disorders of the joints
Tendon and ligament defects
Defects of the skeleton and adnexal structures
Summary
Genetics of Equine Ocular Disease
Key points
Introduction
Multiple congenital ocular anomalies
Congenital stationary night blindness
Equine recurrent uveitis
Ocular squamous cell carcinoma
Ocular manifestations of equine diseases caused by known genetic mutations
Inherited ocular disease with unknown genetic causes
Summary
Genetics of Skin Disease in Horses
Key points
Introduction
Genetics of Equine Endocrine and Metabolic Disease
Key points
Animal models in complex disease genetics
Metabolic syndrome
Dopaminergic neurodegeneration
Summary
Genetics of Equine Muscle Disease
Key points
Introduction
Hyperkalemic periodic paralysis
Glycogen branching enzyme deficiency
Type 1 polysaccharide storage myopathy
Chronic management
Malignant hyperthermia
Myosin heavy chain myopathies
Clinical signs
Pathophysiology
Management
Multiple genetic mutations
Summary
Genetics and Signaling Pathways of Laminitis
Key points
Introduction
Summary
Genetics of Equine Reproductive Diseases
Key points
Introduction
Reproductive disorders caused by chromosome mutations
Molecular genetics of reproductive disorders
Summary
Genetics of Equine Behavioral Traits
Key points
Introduction
How much of horse behavior is heritable?
Molecular genetics of horse behavior
Stereotypic behaviors: are they genetic or are they learned?
Summary