Epigenetics in Cardiovascular Disease, Volume 24

Section I: Introductory information
1. The ever-growing burden of cardiovascular disease
2. Epigenetics concepts - an overview
3. From classical signalling pathway to the nucleus

Section II: Epigenetics mechanisms in cardiovascular disease
4. DNA methylation in cardiovascular disease development
5. Histone modifications in cardiovascular disease initiation and progression
6. Post transcriptional RNA modifications in cardiovascular disease
7. Regulatory RNAs in cardiovascular disease
8. Regulation of splicing in cardiovascular disease
9. Cardiac Transcriptomic Remodelling in Metabolic Syndrome
10. Sex differences in epigenetics mechanisms of cardiovascular disease
11. Epigenetics of cardiac development and iPS cells

Section III: Biomarker value
12. Peripheral Blood DNA and RNA Biomarkers of Cardiovascular Disease in Clinical Practice
13. Epigenetics and physical exercise
14. Long non-coding RNAs and circular RNAs as heart failure biomarkers
15. Artificial intelligence in clinical decision-making for diagnosis of cardiovascular disease

Section IV: Therapeutic potential
16. Therapeutic strategies for modulating epigenetic mechanisms in cardiovascular disease

Section V: Methodological issues
17. RNA-sequencing and single cell RNA-seq in cardiovascular medicine
18. Good laboratory and experimental practices for microRNA analysis in cardiovascular research
19. Analytical challenges in microRNA biomarker development - Best practices for analyzing microRNAs in cell-free biofluids
20. Concept of biological reference materials for RNA analysis in cardiovascular disease
21. Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease.

• Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease
• Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research
• Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare
• Features chapter contributions from a wide range of international researchers in the field

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, cardiovascular disease, biochemistry, and molecular biology; life science researchers; developmental biologists