Epigenetics in Cardiovascular Disease, Volume 24

Preface
SECTION I INTRODUCTORY INFORMATION
CHAPTER 1 The ever-growing burden of cardiovascular disease
CHAPTER 2 Epigenetics concepts: An overview
CHAPTER 3 From classical signaling pathways to the nucleus

SECTION II EPIGENETICS MECHANISMS IN CARDIOVASCULAR DISEASE
CHAPTER 4 DNA methylation in heart failure
CHAPTER 5 Histone modifications in cardiovascular disease initiation and progression
CHAPTER 6 RNA modifications in cardiovascular disease—An experimental and computational perspective
CHAPTER 7 Regulatory RNAs in cardiovascular disease
CHAPTER 8 Regulation of splicing in cardiovascular disease
CHAPTER 9 Cardiac transcriptomic remodeling in metabolic syndrome
CHAPTER 10 Sex differences in epigenetics mechanisms of cardiovascular disease
CHAPTER 11 Epigenetics in cardiac development and human induced pluripotent stem cells

SECTION III BIOMARKER VALUE
CHAPTER 12 Peripheral blood DNA and RNA biomarkers of cardiovascular disease in clinical practice
CHAPTER 13 Epigenetics and physical exercise
CHAPTER 14 Long noncoding RNAs and circular RNAs as heart failure biomarkers
CHAPTER 15 Artificial intelligence in clinical decision-making for diagnosis of cardiovascular disease using epigenetics mechanisms

SECTION IV THERAPEUTIC POTENTIAL
CHAPTER 16 Therapeutic strategies for modulating epigenetic mechanisms in cardiovascular disease

SECTION V METHODOLOGICAL ISSUES
CHAPTER 17 Single-cell RNA sequencing in cardiovascular science
CHAPTER 18 Good laboratory and experimental practices for microRNA analysis in cardiovascular research
CHAPTER 19 Analytical challenges in microRNA biomarker development: Best practices for analyzing microRNAs in cell-free biofluids
CHAPTER 20 Concept of biological reference materials for RNA analysis in cardiovascular disease
CHAPTER 21 Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction
Conclusions and Prespectives

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease.

• Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease
• Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research
• Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare
• Features chapter contributions from a wide range of international researchers in the field

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, cardiovascular disease, biochemistry, and molecular biology; life science researchers; developmental biologists