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SECTION I Spermatogenesis, oogenesis and fertility
1. Epigenome reprogramming in the male and female germ line
2. Genomic imprinting
3. Chromatin remodeling of the male genome during spermiogenesis and embryo development
4. Epigenetic regulation in stem cells
5. Aberrant epigenetics and reproductive disorders
SECTION II Pregnancy/developmental/placental epigenetics
6. Epigenetic reprogramming in the embryo
7. Epigenetic regulation during placentation
8. Epigenetic modulation during pregnancy and pregnancy related disorders
9. Epigenetic involvement in fetal and neonatal origins of late-onset disease
SECTION III Epigenetic – lifestyle, aging and environmental influence
10. Impact of environmental chemicals and endocrine disruptors on mammalian germ cell epigenome
11. Influence of nutrition on reproductive health through epigenetic mechanisms
12. Influence of stress and lifestyle on epigenetic modifications
13. Aging of male and female gametes
SECTION IV Reproductive cancer and epigenetics
14. Testicular and prostate cancers
15. Emerging patterns and implications of breast cancer epigenetics: An update of the current knowledge
16. Ovarian and endometrial cancers
17. Epigenetic aberrations in cervical cancer
SECTION V Epigenetics in diagnosis, prognosis and therapy
18. Natural molecules as epigenetic modifiers in reproduction
Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms.
Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics.
- Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations
- Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers
- Features chapter contributions from international researchers in the field
Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, reproductive biology, endocrinology, molecular biology; life science researchers; oncologists; Obstetricians; pediatricians; immunologists; bioengineers; developmental biologists
- No. of pages:
- © Academic Press 2020
- 12th September 2020
- Academic Press
- eBook ISBN:
- Paperback ISBN:
"I believe this to be the first of many textbooks on this topic. It is a much-needed summary of important advancements in the field of epigenetics and reproductive health. It is a very detailed review intended for expects in the field and those devoted to continued research in this area." --Doody
Dr. Nafisa Balisinor received her B.Sc. and M.Sc. at the Sophia College University of Mumbai, and her Ph.D. at the Institute for Research in Reproduction, University of Bombay (Biochemistry, 1989). She has published widely on topics in reproductive neuroendocrinology and epigenetics, in such peer reviewed journals as the International Journal of Biological Macromolecules, Epigenetics, Endocrinology, Andrologia, and the Journal of Steroid Biochemistry and Molecular Biology. Currently Dr. Nafisa Balasinor is a Scientist and Head of the Department of Neuroendocrinology, at the National Institute for Research in Reproductive Health India, Mumbai, India.
Scientist and Head, Department of Neuroendocrinology, National Institute for Research in Reproductive Health India, Mumbai, India
Dr. Dipty Singh received her Ph.D at the University of Mumbai (Life Sciences, 2010), and her M.Sc at the University of Allahabad (Biotechnology, 2004). Her research interests include reproductive biology, endocrine disruptors, and bacterial cell division proteins and their small molecule inhibitors. In her previous role she was a Research Associate at the Department of Biosciences & Bioengineering, IIT Mumbai, and is now a Scientist at the National Institute for Research in Reproductive Health India, Mumbai, India. She has published a range of peer journals, including Biochemistry, Chemosphere, the Journal of Pharmacopuncture, and the Journal of Nanobiotechnology.
Scientist, National Institute for Research in Reproductive Health India, Mumbai, India
Trygve Tollefsbol is a Professor of Biology and a Senior Scientist in the Comprehensive Center for Healthy Aging, the Comprehensive Cancer Center, the Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol has doctorate degrees in molecular biology and osteopathic medicine and has edited and co-authored numerous books on the topics of epigenetics, cancer and aging and is Series Editor of Translational Epigenetics. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging.
Professor of Biology, Senior Scientist, Comprehensive Cancer Center, Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, AL, USA
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