Description

This new volume of Current Topics in Developmental Biology covers epigenetics and development, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as epigenetic marking of the zebrafish developmental program, functions of DNA methylation and hydroxymethylation in mammalian development, and reprogramming and the pluripotent stem cell cycle.

Key Features

  • Covers the area of epigenetics and development
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as epigenetic marking of the zebrafish developmental program, functions of DNA methylation and hydroxymethylation in mammalian development, and reprogramming and the pluripotent stem cell cycle

Readership

Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

Series Page

Contributors

Preface

Chapter One. Mechanisms and Dynamics of Heterochromatin Formation During Mammalian Development

1 Introduction

2 Heterochromatin in the Early Embryo: A Rather Particular Environment

3 Mechanisms of Heterochromatin Establishment and Inheritance

4 Concluding Remarks

References

Chapter Two. Functions of DNA Methylation and Hydroxymethylation in Mammalian Development

1 Introduction

2 Enzymatic Players

3 Patterns of DNA Methylation and Hydroxymethylation During Development

4 Role of Cytosine Methylation in Genome Regulation

5 Emerging Functions of Cytosine Hydroxymethylation

6 Conclusions

References

Chapter Three. Epigenetic Marking of the Zebrafish Developmental Program

1 Introduction: Setting the Stage for the Zebrafish Developmental Gene Expression Program

2 Turning on Gene Expression at the MZT

3 DNA Methylation Changes During the MZT

4 Developmental Gene Expression Prepatterning by DNA Hypomethylation

5 Prepatterning Developmental Gene Expression by Modified Histones Before ZGA

6 Developmental Epigenetic Fate Map Through the MBT: A Path to Multivalency?

7 Transgenerational Inheritance or De Novo Deposition of Embryonic Epigenetic Marks? Two Models

8 Conclusions and Perspectives

References

Chapter Four. Chromatin Architectures and Hox Gene Collinearity

1 Introduction

2 Hox Gene Function and Genomic Organization

3 The Many Faces of Collinearity

4 Are Polycomb and Trithorax Mediators of Collinearity?

5 Downstream of Polycomb and Trithorax: A Compacted Chromatin Architecture

6 3D Chromatin Organization and Collinearity in Drosophila

7 A 3D Chromatin Timer for Vertebrate Collinearity?

8 A Regulatory Archipelago and Collinearity in Developing Digits

9 Clu

Details

No. of pages:
352
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780123914552
Print ISBN:
9780124160279

About the serial-volume-editor

Reviews

"...the choice to limit the scope of the volume to the epigenetics of development leads to an excellent work that is characterized by both focus and quality."--The Quarterly Review of Biology, Epigenetics and Development