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Epigenetics and Development - 1st Edition - ISBN: 9780124160279, 9780123914552

Epigenetics and Development, Volume 104

1st Edition

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Serial Volume Editor: Edith Heard
Hardcover ISBN: 9780124160279
eBook ISBN: 9780123914552
Imprint: Academic Press
Published Date: 2nd May 2013
Page Count: 352
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Table of Contents

Series Page



Chapter One. Mechanisms and Dynamics of Heterochromatin Formation During Mammalian Development

1 Introduction

2 Heterochromatin in the Early Embryo: A Rather Particular Environment

3 Mechanisms of Heterochromatin Establishment and Inheritance

4 Concluding Remarks


Chapter Two. Functions of DNA Methylation and Hydroxymethylation in Mammalian Development

1 Introduction

2 Enzymatic Players

3 Patterns of DNA Methylation and Hydroxymethylation During Development

4 Role of Cytosine Methylation in Genome Regulation

5 Emerging Functions of Cytosine Hydroxymethylation

6 Conclusions


Chapter Three. Epigenetic Marking of the Zebrafish Developmental Program

1 Introduction: Setting the Stage for the Zebrafish Developmental Gene Expression Program

2 Turning on Gene Expression at the MZT

3 DNA Methylation Changes During the MZT

4 Developmental Gene Expression Prepatterning by DNA Hypomethylation

5 Prepatterning Developmental Gene Expression by Modified Histones Before ZGA

6 Developmental Epigenetic Fate Map Through the MBT: A Path to Multivalency?

7 Transgenerational Inheritance or De Novo Deposition of Embryonic Epigenetic Marks? Two Models

8 Conclusions and Perspectives


Chapter Four. Chromatin Architectures and Hox Gene Collinearity

1 Introduction

2 Hox Gene Function and Genomic Organization

3 The Many Faces of Collinearity

4 Are Polycomb and Trithorax Mediators of Collinearity?

5 Downstream of Polycomb and Trithorax: A Compacted Chromatin Architecture

6 3D Chromatin Organization and Collinearity in Drosophila

7 A 3D Chromatin Timer for Vertebrate Collinearity?

8 A Regulatory Archipelago and Collinearity in Developing Digits

9 Clustering, Coating, Compaction, Compartmentalization, and Contacts: The Five C’s of Collinearity?


Chapter Five. Primordial Germ-Cell Development and Epigenetic Reprogramming in Mammals

1 Embryology

2 PGC Specification

3 Regulation of Germ-Cell Survival and Migration

4 Epigenetic Reprogramming

5 PGC Culture and Embryonic Germ-Cell Derivation

6 Conclusion


Chapter Six. Epigenetics and Development in Plants

1 Introduction

2 Plant Epigenomes: Components and Organization

3 Chromatin-Based Processes During Vegetative Development

4 The Central Role of Epigenetics in Plant Reproductive Development

5 Transgenerational Inheritance of Epigenetic Variation

6 Concluding Remarks and Future Outlook


Chapter Seven. Reprogramming and the Pluripotent Stem Cell Cycle

1 Introduction

2 The Embryonic Stem Cell Cycle

3 Methods for Restoring Pluripotency

4 Critical Stages and Events in Epigenetic Reprogramming

5 DNA Synthesis and Chromatin Remodeling in Reprogramming

6 Concluding Remarks


Chapter Eight. H3K9/HP1 and Polycomb

1 Introduction and Evolutionary Perspective

2 The H3K9/HP1 Pathway and Its Role in Development

3 Polycomb Repressive Pathways

4 Conclusion


Chapter Nine. Parental Epigenetic Asymmetry in Mammals

1 Introduction

2 Generating Asymmetric Nuclear-Based Information in Parental Gametes

3 Immediate Inheritance and Reinforcement of Parental Asymmetry in the One-Cell Zygote

4 Global Loss and Specific Retention of Parental Asymmetries During Preimplantation Development

5 Scarce Maintenance of Parental Epigenetic Asymmetry After Embryo Implantation and Throughout Adulthood

6 Conclusions




This new volume of Current Topics in Developmental Biology covers epigenetics and development, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as epigenetic marking of the zebrafish developmental program, functions of DNA methylation and hydroxymethylation in mammalian development, and reprogramming and the pluripotent stem cell cycle.

Key Features

  • Covers the area of epigenetics and development
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as epigenetic marking of the zebrafish developmental program, functions of DNA methylation and hydroxymethylation in mammalian development, and reprogramming and the pluripotent stem cell cycle


Researchers in cell, developmental, and molecular biology; genetics


No. of pages:
© Academic Press 2013
2nd May 2013
Academic Press
Hardcover ISBN:
eBook ISBN:


"...the choice to limit the scope of the volume to the epigenetics of development leads to an excellent work that is characterized by both focus and quality."--The Quarterly Review of Biology, Epigenetics and Development

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About the Serial Volume Editor

Edith Heard