Epigenetic Gene Expression and Regulation

1st Edition

Editors: Suming Huang Michael Litt C. Ann Blakey
Hardcover ISBN: 9780127999586
eBook ISBN: 9780128004715
Imprint: Academic Press
Published Date: 16th November 2015
Page Count: 482
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Description

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies.

The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues.

The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment.

Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.

Key Features

  • Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies
  • Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring
  • Chapters are replete with clinical examples to empower the basic biology with translational significance
  • Offers more than 100 illustrations to distill key concepts and decipher complex science

Readership

Basic biology and translational researchers above graduate level interested in developmental biology, genetics, health genomics, epigenesis in complex disease, and therapeutic possibilities

Table of Contents

  • Translational Epigenetics Series
  • Preface
  • Acknowledgment
  • Chapter 1. Epigenetic gene expression—an introduction

    • 1. Introduction
    • 2. Epigenetics
    • 3. Future directions and challenges
    • 4. Summary
  • Chapter 2. Histone modifications—models and mechanisms

    • 1. Introduction
    • 2. Chromatin
    • 3. The nucleosome
    • 4. Histones and global mechanisms
    • 5. Summary
  • Chapter 3. Genomic imprinting in mammals—memories of generations past

    • 1. Introduction
    • 2. The life cycle of imprinted regions
    • 3. Mechanisms of genomic imprinting
    • 4. Top-down dissection of imprinted domains
    • 5. Transcriptional interpretation of the imprint
    • 6. Imprinting and human disease
    • 7. Finding new imprinted genes
    • 8. The evolution of imprinting
    • 9. Conclusion
  • Chapter 4. Polycomb and Trithorax factors in transcriptional and epigenetic regulation

    • 1. Introduction
    • 2. Regulators of homeotic genes—PcG and TrxG proteins
    • 3. PcG-mediated gene repression
    • 4. TrxG-mediated transcriptional regulation
    • 5. Targeting of PcG/TrxG complexes to chromatin
    • 6. Crosstalk with other PTMs
    • 7. Regulation of PcG/TrxG function by upstream signaling pathways
    • 8. Concluding remarks and future perspective
  • Chapter 5. Chromatin dynamics and genome organization in development and disease

    • 1. Introduction
    • 2. Technology advances in unraveling chromosome architecture and genome organization
    • 3. Proteins involved in genome organization
    • 4. Intra- and interchromosomal interactions during development
    • 5. Intra- and interchromosomal interactions during carcinogenesis
    • 6. Closing remarks and future directions
  • Chapter 6. ncRNA

Details

No. of pages:
482
Language:
English
Copyright:
© Academic Press 2015
Published:
Imprint:
Academic Press
eBook ISBN:
9780128004715
Hardcover ISBN:
9780127999586

About the Editor

Suming Huang

Affiliations and Expertise

Associate Professor, Dept. of Biochemistry & Molecular Biology, University of Florida College of Medicine

Michael Litt

Affiliations and Expertise

Associate Professor of Medical Education Genetics, Ball State University

C. Ann Blakey

Affiliations and Expertise

Associate Professor, Department of Biology, Ball State University

Reviews

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies.

The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues.

The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment.

Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.