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Eosinophils in Health and Disease - 1st Edition - ISBN: 9780123943859, 9780123946072

Eosinophils in Health and Disease

1st Edition

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Editors: James Lee Helene Rosenberg
Hardcover ISBN: 9780123943859
eBook ISBN: 9780123946072
Imprint: Academic Press
Published Date: 2nd November 2012
Page Count: 678
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Written and edited by leaders in the field, Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance. Despite an explosion of discovery in this area over the last decade, this is the only up-to-date resource on eosinophils and eosinophilia exists. This full-color volume provides an essential collection of world class information that is a must-have for any immunologist’s workbench or bookshelf.

Key Features

  • The only updated, comprehensive source of information on eosinophils on the market
    • Written by over 80 leaders in the field
    • Holistic view of the subject, including basic science, disease-specific chapters, therapeutic options and emerging areas of research


    Researchers, clinical investigators and advanced students in the fields of immunology, autoimmunity, asthma and allergy research and cell biology.

    Table of Contents






    Chapter 1. Historical Overview and Perspective on the Role of the Eosinophil in Health and Disease


    Paul Ehrlich and the Discovery of the Eosinophil

    Early Days: The Eosinophil and Anaphylaxis

    Eosinophil Granule Proteins and their Properties

    Interleukin-5, Eotaxin, and Eosinophil-Derived Cytokines

    Transgenic and Knockout Mice for the Investigation of Eosinophils

    Eosinophil-Associated Diseases

    Conclusion and Future Perspectives



    Chapter 2. The Evolutionary Origins and Presence of Eosinophils in Extant Species


    Invertebrate Hemocytes

    Vertebrate Eosinophil Granulocytes

    Comparative Eosinophilopoiesis

    So, why Eosinophil Granulocytes?


    Chapter 3. Eosinophil Structure and Cell Surface Receptors

    Chapter 3.1 Introduction

    Chapter 3.2 Eosinophil Ultrastructure

    Chapter 3.3 Eosinophil Receptor Profile

    Chapter 4. Ex Vivo Models for the Study of Eosinophils

    Chapter 4.1 Introduction

    Chapter 4.2 Eosinophil Cell Lines

    Chapter 4.3 Isolation and Manipulation of Eosinophils from Human Peripheral Blood

    Chapter 4.4 Induction of Eosinophilia in Mice and the Isolation of Eosinophils for Ex Vivo Manipulations

    Chapter 4.5 Culture and Characterization of Mouse Bone Marrow-Derived Eosinophils

    Chapter 4.6 Modeling Eosinophil Development Ex Vivo from Human CD34+ Cells

    Chapter 5. Eosinophilopoiesis

    Chapter 5.1 Introduction

    Chapter 5.2 Transcriptional Regulation of Eosinophil Lineage Commitment and Differentiation

    Chapter 5.3 Eosinophil Lineage-Committed Progenitors

    Chapter 5.4 Interleukin-5 and its Receptor Molecules

    Chapter 5.5 Extramedullary Recruitment and Proliferation of Eosinophil Progenitors

    Chapter 5.6 Mouse Models Manipulating Eosinophilopoiesis

    Chapter 6. Eosinophil Trafficking

    Chapter 6.1 Introduction

    Chapter 6.2 Eosinophil Chemotaxis

    Chapter 6.3 Adhesion Molecules

    Chapter 6.4 Eosinophil-Endothelial Cell Interactions during Inflammation

    Chapter 6.5 Eosinophils and Circulating Endothelial Progenitor Cells

    Chapter 6.6 In Vivo Assessment of Eosinophil Trafficking by Intravital Microscopy

    Chapter 7. Eosinophil Signal Transduction

    Chapter 7.1 Introduction

    Chapter 7.2 Priming: A Critical Step in the Control of Eosinophil Activation

    Chapter 7.3 Eosinophil Receptor-Mediated Inhibition

    Chapter 7.4 Apoptotic and Survival Signaling in Eosinophils

    Chapter 7.5 Molecular Mechanisms Underlying Eosinophil Hematopoiesis

    Chapter 7.6 Signaling and Degranulation

    Chapter 7.7 Eosinophil Responses to Pathogen-Associated and Damage-Associated Molecular Patterns

    Chapter 8. Eosinophil Secretory Functions

    Chapter 8.1 Introduction

    Chapter 8.2 Release of Cytokines and Chemokines from Eosinophils

    Chapter 8.3 Release of Lipid Mediators: the Role of Lipid Bodies

    Chapter 8.4 Gene-Knockout Mice: What Can They Teach Us about Sequelae Resulting from the Absence of Specific Eosinophil Cationic Proteins?

    Chapter 8.5 The Eosinophil and Airways Hyperresponsiveness: the Role and Mechanisms of Cationic Proteins

    Chapter 8.6 Cell-Free Granules are Functional Secretory Organelles

    Chapter 9. Eosinophils and Anti-Pathogen Host Defense

    Chapter 9.1 Introduction

    Chapter 9.2 Eosinophil-Mediated Antibacterial Host Defense

    Chapter 9.3 Interactions of Eosinophils with Respiratory Virus Pathogens

    Chapter 9.4 Antifungal Immunity by Eosinophils: Mechanisms and Implications in Human Diseases

    Chapter 10. Eosinophils: Mediators of Host-Parasite Interactions

    Chapter 10.1 Introduction

    Chapter 10.2 Eosinophil-Mediated Responses Toward Helminths

    Chapter 10.3 Immune Responses in Helminth Infections

    Chapter 10.4 Eosinophils as Facilitators of Helminth Infection

    Chapter 11. Eosinophil Cell–Cell Communication

    Chapter 11.1 Introduction

    Chapter 11.2 Eosinophil and Nerve Interactions

    Chapter 11.3 Eosinophils as Regulators of Gastrointestinal Physiological Homeostasis

    Chapter 11.4 Eosinophil-Mediated Antigen Presentation

    Chapter 11.5 Eosinophil Modulation of T Cell Activation and Recruitment

    Chapter 11.6 Eosinophil–Mast Cell Interactions

    Chapter 11.7 Plasma Cell/B Cell–Eosinophil Interactions

    Chapter 11.8 Eosinophil–Airway Epithelial Cell Interactions

    Chapter 11.9 The Eosinophil and the Thymus

    Chapter 12. Eosinophil-Mediated Tissue Remodeling and Fibrosis

    Chapter 12.1 Introduction

    Chapter 12.2 Potential Role of Eosinophil Granule Proteins in Tissue Remodeling and Fibrosis

    Chapter 12.3 Role of Eosinophils in Transforming Growth Factor β1-Mediated Remodeling

    Chapter 12.4 Potential Role of Eosinophils and Tumor Necrosis Factor α in Tissue Remodeling

    Chapter 12.5 Esophageal Remodeling and Pediatric Eosinophilic Esophagitis

    Chapter 12.6 Remodeling and Disease Pathology: Adult Eosinophilic Esophagitis

    Chapter 12.7 Human Studies of Remodeling and Fibrosis in Asthma and Allergic Inflammation

    Chapter 13. Eosinophils in Human Disease

    Chapter 13.1 Introduction

    Chapter 13.3 Eosinophils and Skin Diseases

    Chapter 13.4 The Evolving Role of Eosinophils in Asthma

    Chapter 13.5 Eosinophil-Targeted Treatment of Asthma

    Chapter 13.6 Eosinophils and Hemopoietic Processes in Allergic Asthma

    Chapter 13.7 Eosinophil Activities and Virus-Induced Asthma

    Chapter 13.8 Eosinophils and Gastrointestinal Disease

    Chapter 13.9 Rare Hypereosinophilic Syndromes

    Chapter 13.10 Eosinophils and Cancer

    Chapter 13.11 Eosinophils and Chronic Rhinosinusitis

    Chapter 13.12 Eosinophils and Vascular Healing

    Chapter 13.13 Eosinophils and Allograft Rejection

    Chapter 13.14 Eosinophils and Calpain-3 Mutation: A Genetic Cause Implicated in Idiopathic Eosinophilic Myositis

    Chapter 14. Animal Models of Human Pathology

    Chapter 14.1 Introduction: The Trials and Tribulations of Linking Cellular and/or Molecular Pathways and the Pathologies Associated with Inflammation using Animal Models

    Chapter 14.3 Mouse Models of Esophageal Eosinophilia

    Chapter 14.4 Models of Inflammatory Bowel Diseases

    Chapter 14.5 Eosinophil-mediated Events in Mouse Models of Food Allergy

    Chapter 14.6 Models of Eosinophilic Leukemia

    Chapter 14.7 Eosinophils in Veterinary Medicine

    Chapter 15. Antieosinophil Therapeutics

    Chapter 15.1 Introduction

    Chapter 15.2 Insights into the Pathogenesis of Asthma and Other Eosinophil-Mediated Diseases from Antagonists of Interleukin-5 and its Receptor

    Chapter 15.3 Interleukin-5 Receptor-Directed Strategies

    Chapter 15.4 Therapeutic Approaches Targeting Siglecs

    Chapter 15.5 Targeting the FIP1L1–PDGFRα and Variant PDGFRα and PDGFRβ Fusion Kinases

    Chapter 16. Emerging Concepts

    Chapter 16.1 Introduction

    Chapter 16.2 Understanding the Role of MicroRNA in Regulating Immune Responses: A New Approach to Treating Eosinophilic Disorders and Allergic Inflammation?

    Chapter 16.3 Eosinophils in the Zebrafish

    Chapter 16.4 Eosinophils as Immune Modulators: Roles of Indoleamine 2,3 Dioxygenase and Tryptophan Catabolites

    Chapter 16.5 Regulation of Eosinophil Responses by the Epithelial-Derived Cytokines TSLP, IL-25, and IL-33


    Eosinophil Activities Are Complex and Diverse

    Anti-Eosinophil Strategies May Not Be the Only Answer



    No. of pages:
    © Academic Press 2012
    2nd November 2012
    Academic Press
    Hardcover ISBN:
    eBook ISBN:

    About the Editors

    James Lee

    Affiliations and Expertise

    Consultant, Division of Pulmonary Medicine, Associate Professor, Department of Biochemistry and Molecular Biology , Distinguished Mayo Clinic Investigator, Mayo Clinic, Scottsdale, Arizona, USA

    Helene Rosenberg

    Affiliations and Expertise

    Senior Investigator and Section Chief, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    Ratings and Reviews