Enzyme Catalysis and Control

Enzyme Catalysis and Control

1st Edition - August 13, 1984

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  • Editors: Marlene Deluca, Henry Lardy, Richard L. Cross
  • eBook ISBN: 9781483217239

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Description

Current Topics in Cellular Regulation: Volume 24, Enzyme Catalysis and Control is a compendium of papers that discusses phosphoryl transfer reactions, the role of water on the free energy of hydrolysis of pyrophosphate, and the hormonal actions of vitamin D. Other papers describe the regulation lipid metabolism by a lipid-carrying protein, the GABA, and taurine enzymes in mammalian brain. One paper examines the role of vitamin D in the metabolism of cells, as well as in the whole animal. Upon absorption in the body, the vitamin undergoes various metabolic transformations before interacting with specific receptors, and then inducting the genome in the target tissues to generate biological and hormonal responses. Another paper notes the possibility of a genetic defect in cancer cells that results in the abnormal accumulation of sterol carrier protein (SCP) and cholesterol in vivo; and also in the inability to maintain levels of SCP or cholesterol in vitro. One paper shows that tartrate, or other organic acids, secreted into the medium by the penicillia keeps the pH in an optimal range for acid protease degradation of proteins and glycoproteins. This mechanism helps the fungus to survive in a nutrient environment (which is unbalanced with respect to an optimum C/N ratio and at a pH unfavorable to many bacteria and other life forms). Another paper proposes a model for the modulation of ATP synthetase activities and medium exchange reactions by energy input, substrate concentration, or others that affect the microenvironment of the enzyme under certain conditions. The compendium will prove beneficial to molecular biologists, general biologists, microbiologists, and biochemists.

Table of Contents


  • Contributors

    Introduction

    Acknowledgment

    Paul Boyer

    Conference Photographs

    1. NMR Studies of Phosphoryl Transfer Reactions

    2. Role of Water on the Free Energy of Hydrolysis of Pyrophosphate

    3. Control of Oxygen Delivery from the Erythrocyte by Modification of Pyruvate Kinase

    4. Hormonal Actions of Vitamin D

    5. Interaction of Galactosyltransferase with α-Lactalbumin and Substrates

    6. Regulation of Lipid Metabolism by a Lipid-Carrying Protein

    7. Selenium-Glutathione Peroxidase: Properties and Synthesis

    8. Regulation of Metabolism in Penicillium charlesii by Organic Acids: Role of L-Tartaric Acid

    9. Kinetic Analysis of the Specificity of Multisubstrate Carnitine Palmitoyltransferase

    10. GABA and Taurine Enzymes in Mammalian Brain

    11. Biochemistry and Regulation of Signal Transduction by Neuronal Acetylcholine Receptors

    12. Enzymes of Glutamate and Glutamine Biosynthesis in Bacillus licheniformis

    13. Glutamine Synthetase: The Major Mn(II) Enzyme in Mammalian Brain

    14. Regulation of Gluconeogenesis at Phosphoenolpyruvate Carboxykinase

    15. Involvement of Guanidino Groups in Anion-Binding Sites and in Enzyme-Catalyzed Covalent Modification Reactions

    16. Use of Coimmobilized Multienzyme Systems as Models for in Vivo Processes

    17. Mechanism and Regulation of Bovine Liver Fructose-1,6-bisphosphatase

    18. Equilibrium Kinetic Studies of Enzyme Mechanism and Control

    19. Kinetics of Tryptophanase Inactivation/Activation by Sudden Removal/Addition of Potassium Ions with the Aid of a Crown Ether or Cryptand

    20. Mechanism and Regulation of Protein Turnover: Effect of the α-Mannosidase Inhibitor, Swainsonine, on Glycoprotein Degradation

    21. Inhibition of Protein Synthesis Initiation Factors by Naturally Occurring Sulfhydryl Reactive Reagents

    22. Structure and Multistep Activation of the Precursors of Peptides from Honeybee Venom Glands and Frog Skin

    23. Age-Related Effects on Subunit Interactions in Rat Muscle Glyceraldehyde-3-Phosphate Dehydrogenase

    24. Catalysis of Methemoglobin Reduction

    25. Colicin Channels and Cellular Immunity

    26. Mechanism and Regulation of Mitochondrial ATP Synthesis

    27. Binding Change Mechanism for ATP Synthesis by Oxidative Phosphorylation and Photophosphorylation

    28. Contribution of Subunit Interactions to the Effectiveness of Catalysis by Succinyl Coenzyme A Synthetase

    29. Laser-Induced Photogeneration of ATP: A New Approach to the Study of Chemical Kinetics of Muscle Contraction

    30. Inhibition of Mitochondrial F1-ATPase by Adenylyl Imidodiphosphate

    31. Mechanistic Implications of 18O Exchange During ATP Synthesis in Oxidative Phosphorylation

    32. Control of Forward and Reverse Electron Flow in Mitochondria: Thermodynamic Versus Kinetic Considerations

    33. Role of Mg2+ Ions in Several Steps of the Sarcoplasmic Reticulum-ATPase Cycle

    34. Sarcoplasmic Reticulum Ca2+-ATPase: Alterations in Catalysis through Interaction with ATP and ADP

    35. Ca2+-Ca2+ Exchange Catalyzed by the Membrane-Bound Ca2+,Mg2+-ATPase of Sarcoplasmic Reticulum Vesicles

    36. A New Approach to the Mechanism of Photophosphorylation: Modulation of ATP Synthetase Activity by Limited Diffusibility of Nucleotides Near the Enzyme

    37. Specific Interactions of Xanthene Dyes with Nucleotide-Binding Sites of Membrane Energy-Transducing Enzymes and Carriers

    38. Contribution of 18O Technology to the Mechanism of the H+-ATPase from Yeast Plasma Membrane

    Index

    Cumulative Contributors Index

    Contents of Previous Volumes

Product details

  • No. of pages: 534
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: August 13, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9781483217239

About the Editors

Marlene Deluca

Henry Lardy

Richard L. Cross

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