This sixth volume in this established series deals with the biochemical responses of fish to different environmental/ecological factors. Environmental Toxicology captures vital issues affecting the responses of fish to the chemical surroundings of their environment. Chapters included in this volume identify the systems found in fish to deal with xenobiotics, hormonal interactions initiated in the presence of these chemicals, the unique mechanisms used by fish to adjust to the present chemicals, and the new and evolving mixtures of chemicals in their environment. Also included, is a crucial review of the new methods being applied in fish systems to understand the effects of xenobiotics to fish fitness - a key theme in environmental health and critical to the future of fish populations.

Key Features

* Entirely new topic discussion and most recent volume in the acclaimed series * Includes chapters detailed on a cellular level * Introduces discussion of pharmaceutical effects on fish


Toxicologists, regulatory and environmental agencies, fish biochemists, physiologists, aquaculturalists, marine biologists, fish researchers, graduate students studying toxicology, molecular biology, physiology, and biochemistry

Table of Contents

Preface. Contributors. Abbreviations. 1. General - Models and Techniques. 1. The utility of zebrafish as a model for toxicological research (M.J. Carvan III, T.K. Heiden, H. Tomasiewicz). 2. Use of fish cell lines in the toxicology and ecotoxicology of fish (N.C. Bols et al.). 3. Approaches in proteomics and genomics for eco-toxicology (N.D. Denslow, I. Knoebl, P. Larkin). 2. Biotransformations/Toxicokinetics. 4. Interactions between lipids and persistent organic pollutants (POPs) in fish (A.A. Elskus, T.K. Collier, E. Monosson). 5. Metabolic fate of nonylphenols and related phenolic compounds in fish (J.-P. Cravedi, D. Zalko). 6. Pesticide biotransformation in fish (D. Schlenk). 7. Xenobiotic receptors in fishes: Structural and functional diversity and evolutionary insights (M.E. Hahn, R.R. Merson, S.I. Karchner). 3. Cellular Changes. 8. Impacts of environmental toxicants and natural variables on the immune system of fishes (K.G. Burnett). 9. Fish models of carcinogenesis (G.K. Ostrander, J.M. Rotchell). 10. Metallothionein: structure and regulation (P. Kling, P.-E. Olsson). 11. Cell death: Investigation and application in fish toxicology (A.W. Wood, D.M. Janz, G. van der Kraak). 4. Endocrine Aspects. a. Stress and HPI axis. 12. Stress and the hypothalamo-pituitary-interrenal axis: Adrenal toxicology: effects of environmental pollutants on the structure and function of the HPI axis (A. Hontela). 13. Xenobiotic impact on corticosteroid signaling (M.M. Vijayan, P. Prunet, A.N. Boone). b. Thyroid and Retinoids 14 . Thyroid ormones (J.G. Eales, S.B. Brown). 15. The biology


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© 2005
Elsevier Science
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