
Endocrine Gland Development and Disease
Description
Key Features
- Covers the area of endocrine gland development and disease
- International board of authors
- Provides a comprehensive set of reviews covering such topics as sex determination & gonadogenesis and the adrenal, thyroid and pineal glands.
Readership
Table of Contents
Series Page
Contributors
Preface
Chapter One. Pituitary Gland Development and Disease: From Stem Cell to Hormone Production
Abstract
1 Introduction
2 Regulating the Pituitary Organizer and the Growth and Shape of Rathke’s Pouch
3 Activities of Signaling Pathways Intrinsic to Rathke’s Pouch
4 The Role of Signature Transcription Factors in Cell Specification
5 Early-Acting Transcription Factors
6 Emerging Roles for Additional Transcription Factor Families: The Forkheads
7 Pituitary Progenitors: Stem Cells and the Niche
8 Cell Cycle Regulation
9 Vascularization and the Hypophyseal Portal System
10 Conclusion
References
Chapter Two. Development of the Medial Hypothalamus: Forming a Functional Hypothalamic-Neurohypophyseal Interface
Abstract
Abbreviations
1 Introduction
2 Architecture of the Adult Medial Hypothalamus
3 Establishing the Medial Hypothalamus
4 Signaling Ligands in Induction and Regionalization
5 Neuronal Differentiation in the Medial Hypothalamus
6 Establishment of Interfaces
7 Concluding Remarks
Acknowledgments
References
Chapter Three. Mammalian Sex Determination and Gonad Development
Abstract
1 Introduction
2 Development of the Bipotential Genital Ridge
3 Primordial Germ Cells
4 Let Us Get It on: Activation of the Testis Differentiation Pathway
5 Staying Turned on: Activation and Maintenance of Sox9
6 Ovary Differentiation
7 Molecular Genetics of Ovarian Development
8 Mutual Antagonism
9 Conclusions and Future Perspectives
References
Chapter Four. Mechanisms of Thyroid Development and Dysgenesis: An Analysis Based on Developmental Stages and Concurrent Embryonic Anatomy
Abstract
1 Introduction
2 Anatomy and Phylogenic Aspects of Thyroid Development
3 Thyroid Organogenesis and Spectrum of Developmental Defects in Human
4 Thyroid Specification and Determination: Agenesis Versus Athyreosis
5 Embryonic Thyroid Growth: Hypoplasia and Hemiagenesis
6 Defective Thyroid Migration: Ectopic Gland
7 Folliculogenesis and Thyroid Differentiation
8 Embryonic Origin of Thyroid C Cells: An Unresolved Issue
9 Concluding Remarks
Acknowledgments
References
Chapter Five. The Pineal Gland from Development to Function
Abstract
1 Function of the Pineal Gland
2 Cellular Composition of the Pineal Gland
3 Organogenesis of the Pineal Gland, Production of Accessory Organs
4 Development of the Pineal Gland
5 Physiological Roles of Melatonin
6 Pathological Dysregulation of Melatonin Synthesis/Signaling
7 Conclusion
Acknowledgments
References
Chapter Six. From Pancreas Morphogenesis to β-Cell Regeneration
Abstract
1 Anatomy of the Pancreas
2 Diabetes
3 Pancreatic Morphogenesis
4 The Endocrine Differentiation Program
5 Regenerative Medicine
Acknowledgments
References
Chapter Seven. Adrenocortical Development, Maintenance, and Disease
Abstract
1 Introduction
2 The Adrenal Gland: Structure and Function
3 Adrenal Development
4 Theories of Growth and Zonation
5 Factors Involved in Adrenal Development
6 Signaling Pathways Involved in Adrenal Development
7 Models of Development
8 Control of Postnatal Growth, Zonation, and Remodeling
9 Diseases of the Adrenal Cortex
10 Summary
References
Index
Product details
- No. of pages: 344
- Language: English
- Copyright: © Academic Press 2013
- Published: November 27, 2013
- Imprint: Academic Press
- eBook ISBN: 9780123914545
- Hardcover ISBN: 9780124160217
About the Serial Volume Editor
Paul Thomas
Affiliations and Expertise
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