Endocrine Gland Development and Disease

Endocrine Gland Development and Disease

1st Edition - November 27, 2013

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  • Editor: Paul Thomas
  • eBook ISBN: 9780123914545
  • Hardcover ISBN: 9780124160217

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This new volume of Current Topics in Developmental Biology covers endocrine gland development and disease, and with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as sex determination & gonadogenesis, hypothalamus, paraythyroid and placenta.

Key Features

  • Covers the area of endocrine gland development and disease
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as sex determination & gonadogenesis and the adrenal, thyroid and pineal glands.


Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

  • Series Page



    Chapter One. Pituitary Gland Development and Disease: From Stem Cell to Hormone Production


    1 Introduction

    2 Regulating the Pituitary Organizer and the Growth and Shape of Rathke’s Pouch

    3 Activities of Signaling Pathways Intrinsic to Rathke’s Pouch

    4 The Role of Signature Transcription Factors in Cell Specification

    5 Early-Acting Transcription Factors

    6 Emerging Roles for Additional Transcription Factor Families: The Forkheads

    7 Pituitary Progenitors: Stem Cells and the Niche

    8 Cell Cycle Regulation

    9 Vascularization and the Hypophyseal Portal System

    10 Conclusion


    Chapter Two. Development of the Medial Hypothalamus: Forming a Functional Hypothalamic-Neurohypophyseal Interface



    1 Introduction

    2 Architecture of the Adult Medial Hypothalamus

    3 Establishing the Medial Hypothalamus

    4 Signaling Ligands in Induction and Regionalization

    5 Neuronal Differentiation in the Medial Hypothalamus

    6 Establishment of Interfaces

    7 Concluding Remarks



    Chapter Three. Mammalian Sex Determination and Gonad Development


    1 Introduction

    2 Development of the Bipotential Genital Ridge

    3 Primordial Germ Cells

    4 Let Us Get It on: Activation of the Testis Differentiation Pathway

    5 Staying Turned on: Activation and Maintenance of Sox9

    6 Ovary Differentiation

    7 Molecular Genetics of Ovarian Development

    8 Mutual Antagonism

    9 Conclusions and Future Perspectives


    Chapter Four. Mechanisms of Thyroid Development and Dysgenesis: An Analysis Based on Developmental Stages and Concurrent Embryonic Anatomy


    1 Introduction

    2 Anatomy and Phylogenic Aspects of Thyroid Development

    3 Thyroid Organogenesis and Spectrum of Developmental Defects in Human

    4 Thyroid Specification and Determination: Agenesis Versus Athyreosis

    5 Embryonic Thyroid Growth: Hypoplasia and Hemiagenesis

    6 Defective Thyroid Migration: Ectopic Gland

    7 Folliculogenesis and Thyroid Differentiation

    8 Embryonic Origin of Thyroid C Cells: An Unresolved Issue

    9 Concluding Remarks



    Chapter Five. The Pineal Gland from Development to Function


    1 Function of the Pineal Gland

    2 Cellular Composition of the Pineal Gland

    3 Organogenesis of the Pineal Gland, Production of Accessory Organs

    4 Development of the Pineal Gland

    5 Physiological Roles of Melatonin

    6 Pathological Dysregulation of Melatonin Synthesis/Signaling

    7 Conclusion



    Chapter Six. From Pancreas Morphogenesis to β-Cell Regeneration


    1 Anatomy of the Pancreas

    2 Diabetes

    3 Pancreatic Morphogenesis

    4 The Endocrine Differentiation Program

    5 Regenerative Medicine



    Chapter Seven. Adrenocortical Development, Maintenance, and Disease


    1 Introduction

    2 The Adrenal Gland: Structure and Function

    3 Adrenal Development

    4 Theories of Growth and Zonation

    5 Factors Involved in Adrenal Development

    6 Signaling Pathways Involved in Adrenal Development

    7 Models of Development

    8 Control of Postnatal Growth, Zonation, and Remodeling

    9 Diseases of the Adrenal Cortex

    10 Summary



Product details

  • No. of pages: 344
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: November 27, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780123914545
  • Hardcover ISBN: 9780124160217

About the Serial Volume Editor

Paul Thomas

Affiliations and Expertise

School of Biomedical Science, University of Adelaide, Australia

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