Volume 106. Endocrine Gland Development and Disease

Series Page

Contributors

Preface

Chapter One. Pituitary Gland Development and Disease: From Stem Cell to Hormone Production

Abstract

1 Introduction

2 Regulating the Pituitary Organizer and the Growth and Shape of Rathke’s Pouch

3 Activities of Signaling Pathways Intrinsic to Rathke’s Pouch

4 The Role of Signature Transcription Factors in Cell Specification

5 Early-Acting Transcription Factors

6 Emerging Roles for Additional Transcription Factor Families: The Forkheads

7 Pituitary Progenitors: Stem Cells and the Niche

8 Cell Cycle Regulation

9 Vascularization and the Hypophyseal Portal System

10 Conclusion

References

Chapter Two. Development of the Medial Hypothalamus: Forming a Functional Hypothalamic-Neurohypophyseal Interface

Abstract

Abbreviations

1 Introduction

2 Architecture of the Adult Medial Hypothalamus

3 Establishing the Medial Hypothalamus

4 Signaling Ligands in Induction and Regionalization

5 Neuronal Differentiation in the Medial Hypothalamus

6 Establishment of Interfaces

7 Concluding Remarks

Acknowledgments

References

Chapter Three. Mammalian Sex Determination and Gonad Development

Abstract

1 Introduction

2 Development of the Bipotential Genital Ridge

3 Primordial Germ Cells

4 Let Us Get It on: Activation of the Testis Differentiation Pathway

5 Staying Turned on: Activation and Maintenance of Sox9

6 Ovary Differentiation

7 Molecular Genetics of Ovarian Development

8 Mutual Antagonism

9 Conclusions and Future Perspectives

References

Chapter Four. Mechanisms of Thyroid Development and Dysgenesis: An Analysis Based on Developmental Stages and Concurrent Embryonic Anatomy

Abstract

1 Introduction