Endocrine Gland Development and Disease, Volume 106

Series Page

Contributors

Preface

Chapter One. Pituitary Gland Development and Disease: From Stem Cell to Hormone Production

Abstract

1 Introduction

2 Regulating the Pituitary Organizer and the Growth and Shape of Rathke’s Pouch

3 Activities of Signaling Pathways Intrinsic to Rathke’s Pouch

4 The Role of Signature Transcription Factors in Cell Specification

5 Early-Acting Transcription Factors

6 Emerging Roles for Additional Transcription Factor Families: The Forkheads

7 Pituitary Progenitors: Stem Cells and the Niche

8 Cell Cycle Regulation

9 Vascularization and the Hypophyseal Portal System

10 Conclusion

References

Chapter Two. Development of the Medial Hypothalamus: Forming a Functional Hypothalamic-Neurohypophyseal Interface

Abstract

Abbreviations

1 Introduction

2 Architecture of the Adult Medial Hypothalamus

3 Establishing the Medial Hypothalamus

4 Signaling Ligands in Induction and Regionalization

5 Neuronal Differentiation in the Medial Hypothalamus

6 Establishment of Interfaces

7 Concluding Remarks

Acknowledgments

References

Chapter Three. Mammalian Sex Determination and Gonad Development

Abstract

1 Introduction

2 Development of the Bipotential Genital Ridge

3 Primordial Germ Cells

4 Let Us Get It on: Activation of the Testis Differentiation Pathway

5 Staying Turned on: Activation and Maintenance of Sox9

6 Ovary Differentiation

7 Molecular Genetics of Ovarian Development

8 Mutual Antagonism

9 Conclusions and Future Perspectives

References

Chapter Four. Mechanisms of Thyroid Development and Dysgenesis: An Analysis Based on Developmental Stages and Concurrent Embryonic Anatomy

Abstract

1 Introduction

2 Anatomy and Phylogenic Aspects of Thyroid Development

3 Thyroid Organogenesis and Spectrum of Developmental Defects in Human

4 Thyroid Specification and Determination: Agenesis Versus Athyreosis

5 Embryonic Thyroid Growth: Hypoplasia and Hemiagenesis

6 Defective Thyroid Migration: Ectopic Gland

7 Folliculogenesis and Thyroid Differentiation

8 Embryonic Origin of Thyroid C Cells: An Unresolved Issue

9 Concluding Remarks

Acknowledgments

References

Chapter Five. The Pineal Gland from Development to Function

Abstract

1 Function of the Pineal Gland

2 Cellular Composition of the Pineal Gland

3 Organogenesis of the Pineal Gland, Production of Accessory Organs

4 Development of the Pineal Gland

5 Physiological Roles of Melatonin

6 Pathological Dysregulation of Melatonin Synthesis/Signaling

7 Conclusion

Acknowledgments

References

Chapter Six. From Pancreas Morphogenesis to β-Cell Regeneration

Abstract

1 Anatomy of the Pancreas

2 Diabetes

3 Pancreatic Morphogenesis

4 The Endocrine Differentiation Program

5 Regenerative Medicine

Acknowledgments

References

Chapter Seven. Adrenocortical Development, Maintenance, and Disease

Abstract

1 Introduction

2 The Adrenal Gland: Structure and Function

3 Adrenal Development

4 Theories of Growth and Zonation

5 Factors Involved in Adrenal Development

6 Signaling Pathways Involved in Adrenal Development

7 Models of Development

8 Control of Postnatal Growth, Zonation, and Remodeling

9 Diseases of the Adrenal Cortex

10 Summary

References

Index

This new volume of Current Topics in Developmental Biology covers endocrine gland development and disease, and with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as sex determination & gonadogenesis, hypothalamus, paraythyroid and placenta.

• Covers the area of endocrine gland development and disease
• International board of authors
• Provides a comprehensive set of reviews covering such topics as sex determination & gonadogenesis and the adrenal, thyroid and pineal glands.

Researchers in cell, developmental, and molecular biology; genetics