Encyclopedia of the Eye

Encyclopedia of the Eye

1st Edition - April 30, 2010

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  • Editors: Joseph Besharse, Barbara Battelle, Reza Dana, David Beebe, Peter Bex, Paul Bishop, Dean Bok, Patricia D’Amore, Henry Edelhauser, Linda Mcloon, Jerry Niederkorn, Thomas Reh, Ernst Tamm
  • Hardcover ISBN: 9780123741981

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Description

As the first comprehensive reference for the eye, its support structures, diseases, and treatments, Encyclopedia of the Eye is an important resource for all visual scientists, ophthalmologists, and optometrists, as well as researchers in immunology, infectious disease, cell biology, neurobiology and related disciplines. This four-volume reference is unique in its coverage of information on all tissues important for vision, including the retina, cornea and lens. It also covers the physiological and pathophysiologic processes that affect all eye tissues. This Encyclopedia is invaluable for graduate students and postdoctoral fellows who are seeking an introduction to an area of eye research. Each chapter explains the basic concepts and provides references to relevant chapters within the Encyclopedia and more detailed articles across the wider research literature. The Encyclopedia is also particularly useful for visual scientists and practitioners who are researching a new area, seeking deeper understanding of important research articles in fields adjacent to their own, or reviewing a grant outside their immediate area of expertise.

Key Features

  • Written by experts at a level that permits students to grasp key elements of a specific subject
  • Provides an entryway into the major features of current eye research
  • No other source puts this much information, so well-indexed and with so many helpful full color figures and graphics, in the hands of the ophthalmic scientist

Readership

This encyclopedia is invaluable for graduate students and postdoctoral fellows who are seeking an introduction to an area of eye research

Table of Contents

  • Article Title Lead Author

    1 Adaptive immune system and the eye: mucosal immunity, Austin Mircheff

    2 Adaptive Immune System and the eye: T Cell-mediated immunity, Kyle McKenna

    3 Innate Immune System and the eye, Meredith Gregory-Ksander

    4 Role of Complement in Ocular Immune Response, Nalini Bora

    5 Dynamic Immunoregulatory Processes that Sustain Immune Privilege in the Eye, Jerry Niederkorn

    6 Immunosuppressive and Anti-Inflammatory Molecules that maintain Immune privilege of the Eye, Andy Taylor

    7 Antigen Presenting Cells in the Eye and Ocular Surface, Pedram Hamrah

    8 Angiogenesis in the Eye, Claus Cursiefen

    9 Dry Eye: An Immune-Based Inflammation, Michael E. Stern

    10 Penetrating Keratoplasty, D F P Larkin

    11 Immunopathogenesis of HSV Keratitis, Robert Hendricks

    12 Immunopathogenesis of Onchocerciasis (River Blindness), Eric Pearlman

    13 Immunopathogenesis of Pseudomonas Keratitis, Linda Hazlett

    14 Pathogenesis and Immunology of Bacterial Endophthalmitis, Mike Gilmore

    15 Immunobiology of Acanthamoeba Keratitis, Jerry Niederkorn

    16 Immunopathogenesis of Experimental Uveitic Diseases, Rachel Caspi

    17 Pathogenesis of Uveitis in Humans, John Forrester

    18 Immunobiology of Age-related Macular Degeneration, Rafael Ufret-Vincenty

    19 Molecular and Cellular Mechanisms in Allergic Conjunctivitis, Virginia Calder

    20 Immunobiology of Uveal Melanoma, Martine Jager

    22 Pathogenesis of Fungal Keratitis, Eric Pearlman

    23 Lens Structure, David Beebe

    24 Lens determination and induction, Richard Lang

    25 Lens fiber cell differentation, Michael Robinson

    28 Normal age-related changes - crystallin modifications, lens hardening, Kirsten Lampi

    30 Lens regeneration, Panagiotis Tsonis

    31 Structure and evolution of the crystallins, Graeme Wistow

    32 Ionic Permeability and Currents in the Lens, Paul Donaldson

    33 Gap junctions, Eric Beyer

    36 Accommodation Adrian, Glasser

    37 Genetics of congenital cataract, J. Fielding Hejtmancik

    38 Cortical cataracts, Ralph Michael

    39 Nuclear cataracts, Roger Truscott

    40 Posterior subcapsular and anterior polar cataracts, Choun-ki Joo

    42 Genetics of age-related cataracts, Alan Shiels

    43 Posterior Capsule Opacification, I.M. Wormstone

    45 Presbyopia, Adrian Glasser

    46 The Epidemiology of Cataract, Sheila West

    47 Tear film overview, Kazuo Tsubota

    48 Meibomian glands and lipid layer, Thomas J. Millar

    49 Lacrimal gland overview, Sarah Hamm-Alvarez

    50 Lacrima gland hormonal regulation, Austin Mircheff

    51 Lacrimal gland signaling - neural, Driss Zoukhri

    52 Overview of Electrolyte and Fluid Transport across the Conjunctiva, Oscar Candia

    53 Conjunctival Goblet Cells, Robin Hodges

    54 OCULAR MUCINS, Monica Berry

    55 Conjunctiva Immune Surveillance, Erich Knop

    56 Tear drainage, Friedrich Paulsen

    57 Defense mechanisms of tears and ocular surface, Alison McDermott

    58 Cornea Overview, Penny Asbell

    59 The Corneal Epithelium: Cell Biology and Basic Science, Mary Ann Stepp

    60 Corneal Epithelium: Wound Healing Junctions, Attachment to Stroma Receptors, Matrix Metalloproteinases, Intracellular Communications, Elizabeth Fini

    61 Corneal epithelium: response to infection, Linda Hazlett

    62 Corneal epithelium: transport and permeability, Peter Reinach

    63 The Ocular Surface: The Surgical Treatment for Corneal Epithelial Stem Cell Deficiency, Corneal Epithelial Defect, and Peripheral Corneal Ulcer, Noriko Koizumi

    64 Refractive surgery and inlays, Rudy Nuijts

    65 Stem cells of ocular surface, James Funderburgh

    66 Contact lenses, Fiona Stapleton

    67 Imaging of the Cornea, Stephen Kaufman

    68 Corneal nerves: anatomy, Carl Marfurt

    69 Corneal nerves: function, Carlos Belmonte

    70 Corneal stroma, James Funderburgh

    71 Corneal dystrophies, Natalie Afshari

    72 Corneal imaging - clinical, Roger Steinert

    73 Corneal scars, Daniel Dawson

    74 Corneal endothelium overview, David Whikehart

    75 Corneal endothelium signaling mechanisms, Joseph Bonnano

    76 Corneal endothelium regulation of proliferation, Ula Jurkunas

    78 Artifical cornea, May Griffith

    79 Blinking mechanism, Charles McMonnies

    80 Drug delivery to cornea and conjunctiva - esterase and protease directed prodrug design, Ashim Mitra

    81 Inflammation of conjunctiva, Teruo Nishida

    82 Knock out mice models: cornea, conjunctiva, lacrimal gland, Winston Kao

    83 Gene therapy, Rajiv Mohan

    84 Lids: anatomy, pathophysiology and mucocutaneous junction, Ted Wojno

    85 The role of the ciliary body in aqueous humor dynamics. Structural aspects, Ernst Tamm

    86 Ion transport in the ciliary epithelium, Olaf Strauss

    88 Neuroendocrine properties of the ciliary epithelium, Miguel Coca-Prados

    89 Control of Aqueous Humor Flow, Jay McLaren

    90 Ciliary blood flow and its role in aqueous humor formation, Jeffrey Kiel

    91 Pharmacology of aqueous humor formation, Carol Toris

    92 Functinal morphology of the trabecular meshwork, Ernst Tamm

    93 Biomechanics of Aqueous Humor Outflow Resistance, Mark Johnson

    94 The Biology of Schlemm Canal, Dan Stamer

    95 The Fibrillar Extracellular Matrix of the Trabecular Meshwork, Donna Peters

    96 The role of proteoglycans in the trabecular meshwork, Ted Acott

    97 Regulation of Extracellular Matrix Turnover in the Aqueous Humor Outflow Pathways, Rudolf Fuchshofer

    98 The Cytoskeletal Network Of The Trabecular Meshwork, Paul Kaufman

    99 Steroid-Induced Ocular Hypertension and Effects of Glucocorticoids on the Trabecular Meshwork, Abbot Clark

    100 Myocilin, Mike Fautsch

    101 The role of oxidative stress in the trabecular meshwork, Pedro Gonzalez

    102 Biological Properties of the Trabecular Meshwork Cells, Paul Russell

    103 Uveoscleral outflow, Albert Alm

    104 Pharmacology of the aqueous humour outflow, Kathryn Cracknell

    106 The development of the aqueous humor outflow pathways, Ernst Tamm

    108 Immunological Aspects of Aqueous Humor Turnover, Claus Cursiefen

    110 Biomechanics of the optic nerve head, J. Crawford Downs

    112 Structural Changes in the Trabecular Meshwork with POAG, Elke Luetjen-Drecoll

    113 Primary Open Angle Glaucoma, Detlev Spiegel

    114 Pseudoexfoliation syndrome and glaucoma, Ursula Schlotzer-Schrehardt

    115 Pigment Dispersion Syndrome and Pigmentary, Glaucoma Robert Ritch

    116 IOP and damage of ON axons, Robert Nickells

    117 Retinal Ganglion Cell Apoptosis and Neuroprotection, Francesca Cordeiro

    118 The Genetics of Primary Open-Angle Glaucoma, Rand Allingham

    119 Molecular genetics of congenital and juvenile glaucoma, Michael Walter

    120 Animal models of glaucoma, Stanislav Tomarev

    121 Concept of angiogenic privilege, Claus Cursiefen

    122 Angiogenesis in response to hypoxia, H Okano

    123 Angiogenesis in inflammation, Zoltan Szekanecz

    124 Angiogenesis in wound healing, Omaida Velazquez

    125 Hemangiogenesis vs lymphangiogenesis, Diane Bielenberg

    126 Innate immunity and angiogenesis, Ralph Kelly

    128 Molecular mechanisms of angiostasis, Raghu Kalluri

    129 Stability and functional integrity of new blood vessels, Akiyoshi Uemura

    130 Vessel Regression, Hans-Peter Hammes

    131 Blood:retinal barrier, Jose G. Cunha-Vaz

    132 RPE barrier, Lawrence J Rizzolo

    133 Properties and Functions of the vessels of the Ciliary Body, Susan Kidson

    136 Anatomy and Regulation of the Optic Nerve Blood Flow, Alon Harris

    137 BREAKDOWN OF THE BLOOD-RETINAL BARRIER, Stanley Vinores

    138 Breakdown of the RPE blood-retinal barrier, Mary Elizabeth Hartnett

    139 Macular edema, Robert Frank

    140 Central retinal vein occlusion, Sohan Hayreh

    141 Pathological retinal angiogenesis, Anthony Adamis

    142 Development of the Retinal Vasculaure, Tailoi Chan-Ling

    143 Choroidal Neovascularization, Scott Cousins

    144 The Vascular Stem Cell, Maria Grant

    145 CORNEAL ANGIOGENESIS, Dimitri Azar

    146 Avascularity of the cornea, Jayakrishina Ambati

    147 Retinal Pigment Epithelial - Choroid Interactions, Knatokie Ford

    149 Pericytes and Microvascular Remodeling: Regulation of Retinal Angiogenesis, Ira Herman

    150 Evolution of opsins, Todd Oakley

    151 Genetic dissection of invertebrate phototransduction, Baruch Minke

    152 Phototransduction in Limulus photoreceptors, Richard Payne

    153 MICROVILLAR AND CILIARY PHOTORECEPTORS IN MOLLUSCAN EYES, Enrico Nasi

    154 The Photoresponse in Squid, Jane Mitchell

    155 The physiology of photoreceptor synapses and other ribbon synapses, Wallace B. Thoreson

    157 Limulus eyes and their circadian regulation, Barbara Battelle

    158 Circadian rhythms in the fly's visual system, Elzbieta Pyza

    159 Fish retinomotor movements, Beth Burnside

    160 The circadian clock in the retina regulates rod and cone pathways, Stuart Mangel

    161 Circadian Regulation of Ion Channels in Photoreceptors, Gladys Ko

    162 Circadian Metabolism in the Chick Retina, P. Michael Iuvone

    163 The Colorful Visual World of Butterflies, Francesca Frentiu

    164 Polarized-Light Vision in Land and Aquatic Animals, Tom Cronin

    165 Zebra fish as a model for understanding retinal diseases, Susan Brockerhoff

    166 Zebra fish - Retinal Development and Regeneration, David R. Hyde

    167 Xenopus laevis as a model for understanding retinal diseases, Orson Moritz

    168 Retinal Degeneration Through the Eye of the Fly, Nansi Colley

    169 Developmental Anatomy of the Retinal and Choroidal Vasculature, Joe G Hollyfield

    170 Post-Golgi trafficking and ciliary targeting of rhodopsin, Dusanka Deretic

    171 PHYSIOLOGICAL ANATOMY OF THE RETINAL VASCULATURE, Sohan Hayreh

    172 Physiological Anatomy of the Choroidal Vasculature, Sohan Hayreh

    173 Rod and cone photoreceptor cells: inner and outer, David S Williams

    175 Rod and cone photoreceptor cells: outer segment membrane renewal, David S Williams

    176 Light-driven translocation of signaling proteins in vertebrate photoreceptors, Vadim Arshavsky; Peter Calvert

    177 Rod photoreceptor cells: soma and synapse, Robert Smith

    178 Cone photoreceptor cells: soma and synapse, Robert Smith

    179 Morphology of interneurons: horizontal cells, Leo Peichl

    180 Morphology of interneurons: bipolar cells, Silke Haverkamp

    181 Morphology of interneurons: amacrine cells, Enrica Strettoi

    182 Morphology of interneurons: interplexiform cells, Doug Mcmahon

    183 Phototransduction: rhodopsin, Kris Palczewski

    184 RETINAL PIGMENT EPITHELIUM: CYTOKINE MODULATION OF EPITHELIAL PHYSIOLOGY, Sheldon Miller

    185 Phototransduction: the visual cycle, Gabriel Travis

    186 Phototransduction: Phototransduction in Rods, Yingbin Fu

    187 Phototransduction: inactivation in rods, Vsevolod Gurevich

    188 Phototransduction: adaptation in rods, Trevor Lamb

    189 Phototransduction: phototransduction in cones, Vladimir Kefalov

    190 Phototransduction: inactivation in cones, Vsevolod Gurevich

    191 Phototransduction: adaptation in cones, Trevor Lamb

    192 Circadian Photoreception, Ignacio Provencio

    193 Retinal Cannabinoids, Stephen Yazulla

    194 Information Processing in the Retina, Frank Werblin

    195 Information processing: horizontal cells, Arlene A. Hirano

    196 Information processing: bipolar cells, Samuel Wu

    197 Information processing: amacrine cells, Robert Marc

    198 Information processing: ganglion cells, Thomas Muench

    199 Information processing: contrast sensitivity, Jonathan, B. Demb

    200 Information processing: direction sensitivity, Z. Jimmy Zhou

    201 Information processing: retinal adaptation, Kenneth Alexander

    202 Glutamate Receptors in Retina, Malcolm Slaughter

    203 GABA Receptors in the Retina, Stephen Yazulla

    204 THE ROLE OF ACETYLCHOLINE AND ITS RECEPTORS IN RETINAL PROCESSING, Kent T Keyser

    205 Neurotransmitters and receptors: dopamine receptors, P. Michael Iuvone

    206 Neurotransmitters and receptors: melatonin receptors, Allan Wiechmann

    207 Neuropeptides: localization, Nicholas Brecha

    208 Neuropeptides: function, Nicholas Brecha

    209 Primary photoreceptor degenerations: terminology, Richard G Weleber

    210 Primary photoreceptor degenerations: retinitis pigmentosa, Richard G Weleber

    211 Secondary photoreceptor degenerations: age-related macular degeneration, L Johnson

    212 Secondary photoreceptor degenerations, Michael Gorin

    213 Retinal Vasculopathies: Diabetic Retinopathy, Jayakrishina Ambati

    214 Retinopathy of Prematurity, Mary Elizabeth Hartnett

    215 Color blindness: inherited, Joseph Carroll

    216 Color blindness: acquired, Joseph Carroll

    217 Injury and repair: light damage, Robert Anderson

    218 Injury and repair: neovascularization, Jayakrishina Ambati

    219 Injury and repair responses: retinal detachment, Steven Fisher; Geoffrey Lewis

    220 Injury and Repair: Retinal Remodeling, Robert Marc

    221 Injury and repair: stem cells and transplantation, Michael Young

    222 Injury and Repair: Prostheses, Gerald Chader

    223 Anatomically Separate Rod and Cone Signalling Pathways, Steven Nusinowitz

    224 Unique specializations - functional: dynamic range of vision systems, Aapakkam Sampath

    225 The Photoreceptor Outer Segment as a Sensory Cilium, Joseph Besharse

    226 Non-Invasive Testing Methods: Multifocal Electrophysiology, Erich Sutter

    227 Phototransduction: Retina: Alternative Visual Cycle in Muller Cells, Gabriel Travis

    229 EVALUATION OF THE TEAR FILM, Alan Tomlinson

    230 Ocular Media Clarity and Straylight, Thomas JTP van den Berg

    231 Pupil, Paul Gamlin

    232 Chromatic function of the cones, David H Foster

    233 Photopic, mesopic and scotopic vision and changes in visual performance, John Barbur

    234 Acuity, Michael Crossland

    235 Contrast sensitivity, Peter Bex

    236 Binocular Vergence Eye Movements and the Near Response, Cliff Schor

    237 Fundamentals of Stereopsis, Laurie M. Wilcox

    239 Astigmatism, Michael Cox

    241 Myopia Fuensanta, A. Vera-Diaz

    242 Refractive surgery, Susana Marcos

    243 Amblyopia, Dennis Levi

    244 Hyperopia, Elise Harb

    245 Perimetry, David Henson

    246 Adaptive optics, David Williams

    247 Optical Coherence Tomography, Wolfgang Drexler

    248 Eye field transcription factors, Michael Zuber

    249 Embryology and early patterning, Paola Bovolenta

    250 Coordinating Division and Differentiation in Retinal Development, Rod Bremner

    251 Retinal Histogenesis, Thomas Reh

    252 Histogenesis: cell fate: signaling factors, Valerie Wallace

    253 Photoreceptor development: early steps/fate, Anand Swaroop

    254 Ganglion cell development: early steps/fate, Nadean Brown

    255 Intraretinal circuit formation, Rachel Wong

    256 Anatomy, aging, and anomalous posterior vitreous detachment, Jerry Sebag

    257 The molecular composition of the vitreous and aging changes, Paul Bishop

    258 Vitreous: Cellular origin, formation and turnover of the vitreous, Willi Halfter

    259 Formation and regression of the primary vitreous and hyaloid vascular system, Richard Lang

    260 Hyalocytes, Tatsuro Ishibashi

    261 Anti-angiogenic properties of vitreous, Gerard Lutty

    262 Regulation of Intraocular Oxygen by the Vitreous, Gel Nancy Holekamp

    264 Pharmacological vitreolysis, Arnd Gandorfer

    265 Rhegmatogenous retinal detachment, David Charteris

    266 Proliferative vitreoretinopathy, Paul Hiscott

    267 The Role of the Vitreous in Macular Hole Formation, William Smiddy

    268 Hereditary Vitreoretinopathies, Martin Snead

    269 The physiologic consequences of vitreous composition, Mike Trese

    270 The Bony Orbit: Bony Anatomy and Orbital Fracture, Andrew R. Harrison

    271 The Bony Orbit: Orbital Imaging, Andrew R. Harrison

    272 Eyelid Anatomy and the Pathophysiology of Blinking, Craig Evinger

    273 Differentiation and Morphogenesis of Extraocular Muscles, Drew M. Noden

    274 Extraocular Muscles: Extraocular Muscle Anatomy, Linda K. McLoon

    275 Extraocular Muscles: Extraocular Muscle Metabolism, Francisco Andrade

    276 Extraocular Muscles: Proprioception and Muscle Spindles, Roland Blumer

    277 Extraocular Muscles: Strabismus and Nystagmus at the Muscle/Eye Movement Level, R. John Leigh; Alessandro Serra

    278 Congenital Cranial Dysinnervation Disorders, Thomas Bosley

    279 Extraocular Muscles: Extraocular Muscle Involvement in Disease, Fatima Pedrosa-Domellof

    280 Extraocular Muscles: Thyroid Eye Disease, Rebecca Bahn; Marius N. Stan

    281 The Active Pulley Hypothesis, Joseph Demer

    282 Orbital Soft Tissue Biomechanics, Sander Schutte

    283 Orbital Masses and Tumors, Ioannis Mavrikakis

    284 Vascular Anatomy Michael, S Lee

    285 Cranial Nerves and Autonomic Innervation, Linda K. McLoon

    286 Optic Nerve: Optic Neuritis, Mathias Bahr; Katharina Hein

    287 Ischemic optic neuropathy, Sohan Hayreh

    288 Optic Nerve: Inherited Optic Neuropathies, Alfredo Sadun

    289 Extraocular Muscles: Functional Assessment in the Clinic, Stephen Christiansen

Product details

  • No. of pages: 2344
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: April 30, 2010
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123741981

About the Editors

Joseph Besharse

Joseph Besharse
Dr. Besharse is currently The Marvin Wagner Professor and Chair of the Department of Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin. He received his BA degree from Hendrix College (Conway, Arkansas) and MA and PhD degrees from Southern Illinois University. After a brief period on the faculty at Old Dominion University in Virginia, he moved to Columbia University as a post-doctoral fellow in retinal research. He was appointed to the faculty of Department of Cell Biology and Anatomy at Emory University School of Medicine in 1977, becoming full professor in 1984. He assumed the position of Professor and Chair of Anatomy and Cell Biology at the University Kansas School of Medicine (Kansas City) in 1989 and moved on to his present position at Medical College of Wisconsin in 1997. Dr. Besharse’s research has focused on membrane turnover, circadian clocks, and microtubule-based transport in photoreceptors with special attention to fundamental pathways that are disrupted in photoreceptor degenerative diseases. His research has been continuously funded by the National Institutes of Health since 1978. In addition to his roles as Department Chair and a principal investigator, he directs an NIH funded training program in Vision Science. Dr. Besharse is a past member of the editorial boards of Investigative Ophthalmology and Vision Science and Vision Neuroscience and served as the Retina Section Editor of Experimental Eye Research. He has served as a Trustee of the Association for Research in Vision and Ophthalmology, and has served two full terms as a member of two different NIH study sections. Among his awards are the Alcon Research Award for outstanding research in Vision Science (1993), the Alumni Achievement Award from Southern Illinois University (1998) and the Distinguished Service Award from the Association for Research in Vision and Ophthalmology (2005). He is a Gold Fellow of ARVO.

Affiliations and Expertise

Dept of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin

Barbara Battelle

Reza Dana

Reza Dana
In addition to his role as Senior Scientist and Co-Director at the Schepens Eye Research Institute, Dr. Reza Dana holds the Claes H. Dohlman Chair in Ophthalmology at Harvard Medical School. He is Director of the Cornea & Refractive Surgery Service at the Massachusetts Eye & Ear, and serves as the Vice Chairman of the Harvard Department of Ophthalmology and Associate Chief of Ophthalmology for Academic Programs at Massachusetts Eye and Ear. After graduating Summa Cum Laude from St. Paul’s School in New Hampshire, he completed his bachelor’s (Phi Beta Kappa), graduate, and medical education at Johns Hopkins University. He performed his residency in Ophthalmology at the Illinois Eye and Ear Infirmary in Chicago, followed by a clinical fellowship in Cornea and External Diseases at the Wills Eye Hospital in Philadelphia. Reza then completed additional fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, and in Ocular and Transplantation Immunology at the Schepens Eye Research Institute. Dr. Dana also holds a Master of Science degree in Management from Harvard University. Reza has been a member of the full-time Harvard faculty since 1995. As a clinician-scientist, he has a particular interest in the molecular and cellular mechanisms of inflammation as they pertain to the ocular surface and anterior segment pathologies, including dry eye, allergy, wound healing responses, and transplant rejection.

Affiliations and Expertise

Schepens Eye Research Institute, Boston, MA, USA

David Beebe

Peter Bex

Paul Bishop

Dean Bok

Affiliations and Expertise

Jules Stein Eye Institute, Devid Geffin School of Medicine at UCLA

Patricia D’Amore

Henry Edelhauser

Linda Mcloon

Jerry Niederkorn

Thomas Reh

Dr. Reh is Professor of Biological Structure and Director of the Neurobiology and Behavior Program at the University of Washington. He is currently a member of the Scientific Advisory Board of the Foundation Fighting Blindness, and of a start-up biotechnology company, Acucela. He has received several awards for his work, including the AHFMR and Sloan Scholar awards and has published over 100 journal articles, reviews and books. Funded by numerous N.I.H. and private foundation grants, his lab is focused on the development and repair of the retina, with an overall goal of understanding the cellular and molecular biology of regeneration in the eye.

Affiliations and Expertise

Professor of Biological Structure and Director of the Neurobiology and Behavior Program, University of Washington, Seattle, USA

Ernst Tamm

Affiliations and Expertise

Professor and Chairman

About the Editor in Chief

Darlene Dartt

Darlene Dartt
Senior Scientist, The Harold F. Johnson Research Scholar, and Senior Scientist, Schepens Eye Research Institute; Associate Professor, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. At the Schepens Eye Research Institute Dr. Dartt served as the Acting Director of Research and the Director of Scientific Affairs for ten years. She received her AB degree from Barnard College (Columbia University) in New York City and her PhD from the Department of Physiology at the University of Pennsylvania in Philadelphia. After post-doctoral fellowships at the University of Copenhagen, Denmark, and Tufts University School of Medicine in Boston, Dr. Dartt joined the Schepens Eye Research Institute in 1985. Her primary research interest is the neural regulation of tear production. Her research focuses on the signaling pathways used by nerves and growth factors in the lacrimal gland and conjunctival goblet cells to induce secretion and proliferation and how dysregulation of these pathways can lead to dry eye syndromes in mouse models and humans, particularly after refractive surgery. She has been continuously funded by NIH since 1980 for this work. Dr. Dartt directs the Institute’s Department of Defense Research Program and chaired four Military Vision Research Symposia. She served on and chaired the ARVO Cornea Program Planning Committee and served on the Members in Training Committee. She was a founding member, a member of the organizing committee, and more recently Treasurer for the Tear Film and Ocular Surface Society. She has been on the organizing committee for the three Biennial Cornea Conferences in Boston, MA. She served as Vice-President for North America for the International Society for Eye Research and a Councilor for the International Society for Contact Lens Wear. She is on the Editorial Board for Investigative Ophthalmology and Visual Science, Experimental Eye Research, and The Ocular Surface. She served on the Review Panel for Fight For Sight and has been an Ad Hoc member of numerous NEI and NIAMS study sections. She received the Lew R. Wasserman Merit Award by Research to Prevent Blindness and is a Gold Fellow of ARVO.

Affiliations and Expertise

Schepens Eye Research Institute, Boston, MA, USA

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