Emission Tomography

1st Edition

The Fundamentals of PET and SPECT

Authors: Miles Wernick John Aarsvold
Hardcover ISBN: 9780127444826
eBook ISBN: 9780080521879
Imprint: Academic Press
Published Date: 18th November 2004
Page Count: 596
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PET and SPECT are two of today’s most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world’s fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging.

Key Features

Contains thorough tutorial treatments, coupled with coverage of advanced topics Three of the four holders of the prestigious Institute of Electrical and Electronics Engineers Medical Imaging Scientist Award are chapter contributors *Include color artwork


Neuroscientists, bioengineers, biophysics, and neurologists.

Table of Contents

Contributors Foreword Preface Acknowledgments

  1. Imaging Science Bringing the Invisible to Light I. Preamble II. Introduction III. Imaging Science IV. Fundamental and Generic Issues of Imaging Science V. Methodology and Epistemology VI. A View of the Future
  2. Introduction to Emission Tomography I. What is Emission Tomography? A. The Tracer Principle B. Tomography II. The Making of an Emission Tomography Image A. Single-Photon Emission Computed Tomography B. Positron Emission Tomography C. Image Reconstruction D. Image Analysis III. Types of Data Acquisition: Static, Dynamic, Gated, and List Mode IV. Cross-Sectional Images V. Radiopharmaceuticals and Their Applications VI. Developments in Emission Tomography
  3. Evolution of Clinical Emission Tomography I. Introduction II. The Beginnings of Nuclear Medicine A. Developments Before 1945 B. The Next 25 Years (1945–1970) III. Early Imaging Devices A. Early Scanning Imagers B. Early Devices Based on Gamma Cameras C. Early Dedicated Positron-Emission Imagers IV. Evolution of Emission Tomography and Initial Applications A. Anger Camera Developments B. Radiopharmaceutical Targeting Agents C. Early Theoretical Developments V. Clinical Applications A. Brain Imaging B. Thyroid Imaging and Therapy C. Parathyroid Disease D. Cardiac Imaging E. Lung Imaging F. Kidney Imaging G. Bone Imaging H. Reticuloendothelial System Imaging I. Pancreas Imaging J. Tumor Imaging K. Molecular Biology Applications VI. Summary
  4. Basic Physics of Radioisotope Imaging I. Where Do the Nuclear Emissions Used in Imaging Come From? A. Nuclear Constituent


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© Academic Press 2004
Academic Press
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About the Author

Miles Wernick

Affiliations and Expertise

Illinois Institute of Technology, Chicago, U.S.A.

John Aarsvold

Affiliations and Expertise

Emory University and the Atlanta VA Hospital, Decatur, Georgia, U.S.A.


"This is an outstanding book that covers emission tomography with great clarity and detail with contributions by many of the most prominent scientists in the field. It belongs (opened) on the desk of all graduate students and scientists working in medical radionuclide imaging." --Mark T. Madsen, PhD(University of Iowa) in Doody Reviews (February 2005)