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Emerging Technologies for Heart Diseases - 1st Edition - ISBN: 9780128137048, 9780128137055

Emerging Technologies for Heart Diseases

1st Edition

Volume 2: Treatments for Myocardial Ischemia and Arrhythmias

Editor: Udi Nussinovitch
Hardcover ISBN: 9780128137048
eBook ISBN: 9780128137055
Imprint: Academic Press
Published Date: 19th August 2020
Page Count: 730
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The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation.

Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas.

Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options.

Key Features

  • Provides a comprehensive review of the latest therapeutic developments for heart failure, valvular disorders, myocardial ischemia and arrhythmias, and their clinical implications
  • Written by both specialists in the field and established researchers, it delivers a review of emerging medical technologies and presents insight into their therapeutic promise
  • Chapters are arranged according to disease pathogeneses and relevance and include coverage of the mechanical, electrophysiological, and biological approaches for the management of patients with myocardial ischemia and arrhythmias


Biomedical companies and basic scientists who develop biological and device-based approaches for the treatment of heart conditions. Medical professionals who wish to enhance their knowledge of current and emerging medical technologies developed for the treatment of cardiovascular diseases including cardiologists, cardio-thoracic surgeons, internal-medicine specialists. Medical students who are interested in medical advancements will find this book of great interest.

Table of Contents

SECTION 5: Treatment of ischemic heart disease
24. Coronary Balloon Angioplasty, Stenting, and Bioabsorbable Scaffolds
25. Coronary thrombectomy
26. Coronary atherectomy and treatments for calcified coronary lesions
27. Treatment of chronic total occlusion
28. Minimally-invasive device-based approaches for improving cardiac perfusion
29. Gene therapy approaches to cardiac neovascularization and protection from ischemia

SECTION 6: Treatment and prevention of ventricular tachyarrhythmias
30. The past, present and future of implantable electrical defibrillators
31. Electrophysiological mapping and cardiac ablation therapy for the prevention of ventricular arrhythmias
32. Gene and cell therapy approaches for the prevention and treatment of ventricular arrhythmia

SECTION 7: Treatment and prevention of supraventricular tachyarrhythmias
33. Ablation therapy and implantable device-based approaches for supraventricular arrhythmias
34. Gene and cell-based therapies for the prevention and treatment of supraventricular arrhythmias

SECTION 8: Treatment and prevention of bradyarrhythmias
35. Cardiac rhythm devices of today and tomorrow
36. Molecular therapies for bradyarrhythmias
37. Cell therapy approaches for treatment of bradyarrhythmias
38. Optogenetics for cardiac pacing and termination of arrhythmias
39. Non-optognetic approaches for leadless cardiac pacing

SECTION 9: Flexible electronics for cardiac monitoring and therapy
40. Organ Conformal Electronics for Cardiac Therapeutics

SECTION 10: Device-based therapies for prevention of cerebral embolization
41. Embolic protection devices for stroke prevention during cardiac interventions
42. Percutaneous closure of the left atrial appendage for stroke prevention
43. Devices for continuous embolic protection

SECTION 11: Noninvasive methods for structural heart defects
44. Transcatheter closure of atrial septal defect in adults
45. Catheter-based treatments for ventricular septal defects

SECTION 12: Novel treatments for hypertension
46. Non-pharmacological therapies for uncontrolled hypertension


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© Academic Press 2020
19th August 2020
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editor

Udi Nussinovitch

Udi Nussinovitch, MD, PhD graduated from the Sackler Faculty of Medicine, Tel Aviv University, training at the Sheba Medical Center, Rambam Healthcare Center and Meir Medical Center, while concurrently graduating with a PhD in cardiac electrophysiology from the Technion Institute of Technology, Israel. Dr Nussinovitch has dedicated his research to investigating novel therapeutic approaches for cardiac disorders and the modulation of the cardiac electrophysiologic substrate for therapeutic purposes. He serves as director of the Applicative Cardiovascular Research Center (ACRC), affiliated to Tel Aviv University. Dr Nussinovitch founded several biotech companies, and has been the recipient of several research awards. He carries out his clinical work at the Meir Medical Center, a medical facility and leading referral center in Israel.

Affiliations and Expertise

Applicative Cardiovascular Research Center (ACRC) and Department of Cardiology, Meir Medical Center, affiliated to Tel Aviv University, Israel

Ratings and Reviews