Emerging Horizons in Neuromodulation

Series Page

Contributors

Chapter One. Neuromodulation

1 Introduction

Chapter Two. Computational Models of Neuromodulation

1 Introduction

2 Foundations of Neurostimulation Modeling

3 Stimulation Safety

4 Spinal Cord Stimulation for Pain

5 Deep Brain Stimulation for Parkinson’s Disease

6 Limitations of Computational Models

7 Conclusions

References

Chapter Three. Neurophysiology of Deep Brain Stimulation

1 Electric Field and Charge Distribution

2 A Tool for Understanding the Functions of Human Deep Brain Structures

3 Neurophysiology

4 Behavioral Neurophysiology

5 Neurochemistry

6 Future Perspectives: Development of New Adaptive Deep Brain Stimulation (aDBS) Systems

References

Chapter Four. Neurophysiology of Cortical Stimulation

1 Introduction

2 Basic Principles of TMS

3 Repetitive Transcranial Magnetic Stimulation

4 Theta Burst Stimulation

5 Paired Associative Stimulation

6 Transcranial Electrical Stimulation with Pulsed Currents

7 Transcranial Direct Current Stimulation

8 Implanted Cortical Stimulation

9 Induced Currents into the Brain

10 Comparisons Between the Methods of Stimulation

11 Safety and Contraindications

12 Neural Circuit Activation by Cortical Stimulation: Spatial Aspects

13 Neural Circuit Activation by Cortical Stimulation: Temporal Aspects

14 Plasticity and Priming

15 Neuroprotection

16 General Principles of the Therapeutic Efficacy of Cortical Stimulation

17 Conclusion

References

Chapter Five. Neural Mechanisms of Spinal Cord Stimulation

1 Introduction

2 Neuropathic Pain

3 Peripheral Vascular Disease

4 Visceral Diseases

5 Cardiac Diseases

6 Conclusions

References

Further Reading

Chapter Six. Magnetoencephalography and Neuromodulation

1 Introduction

2 MEG and TMS

3 MEG and Transcranial Direct or Alternate Current Stimulation

4 MEG and DBS

5 Conclusions and Outlook

References

Chapter Seven. Current Challenges to the Clinical Translation of Brain Machine Interface Technology

1 Introduction and Motivation

2 Device Hardware

3 Performance

4 Surgical Considerations

5 Conclusion

References

Further Reading

Chapter Eight. Nanotechnology in Neuromodulation

1 Introduction

2 Nanotechniques: Scale and Properties

3 Fabricating Nanoelectrodes for Neuromodulation

4 Neurochemical/Neurotransmitter Monitoring

5 Computational Models and Nanoelectrodes

6 Minimally Invasive Neuromodulation

7 Nanopower to the Neuromodulators!

8 Nanoneuromodulation

References

Chapter Nine. Optogenetic Neuromodulation

1 Introduction

2 Basics of Optogenetics

3 Clinical Insights from Optogenetics

4 Translational Optogenetics

5 Conclusions

References

Chapter Ten. Diffusion Tensor Imaging and Neuromodulation

1 Overview

2 Diffusion Weighted and Diffusion Tensor Magnetic Resonance Imaging

3 Fiber Tractography

4 Deterministic and Probabilistic Fiber Tracking

5 Accuracy of Diffusion Tensor Imaging Fibertracking and Its Use in Neurosurgery

6 Electric Field Simulation

7 Applications

8 Development of a New Target Region Utilizing the DTI Technique: A New DBS Target to Treat Major Depression

9 DTI FT and the Concept of Network Balances

10 Summary

References

Further Reading

Chapter Eleven. Multimodal Imaging and Image Analysis Techniques for Neuromodulation

1 Introduction

2 Digital Atlases of Subcortical Structures

3 Anatomical Image Acquisition Techniques for Planning DBS Procedures

4 Functional Magnetic Resonance Imaging for Planning DBS Procedures

5 Future Perspectives and Multimodal Integration

References

Chapter Twelve. DBS and Electrical Neuro-Network Modulation to Treat Neurological Disorders

1 Introduction

2 ENM in the Treatment of Chronic Pain

3 Electrical ENM Approaches to Movement Disorders

4 ENM in Epilepsy

5 Conclusions

References

Chapter Thirteen. Neuromodulation in Psychiatric Disorders

1 Introduction

2 Neuromodulation in Addiction

3 Neuromodulation in Alzheimer’s Disease

4 Neuromodulation in Depression

5 Neuromodulation in OCD

6 Neuromodulation in TS

7 Neuromodulation in Other Psychiatric Indications

8 Conclusion

References

Further Reading

Chapter Fourteen. Ethical Aspects of Neuromodulation

1 Introduction

2 Personal Integrity

3 Clinical Integrity

4 Scientific Integrity

5 Conclusion

References

Subject Index

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