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Emerging Horizons in Neuromodulation - 1st Edition - ISBN: 9780124047068, 9780124051805

Emerging Horizons in Neuromodulation, Volume 107

1st Edition

New Frontiers in Brain and Spine Stimulation

Serial Volume Editors: Clement Hamani Elena Moro
Hardcover ISBN: 9780124047068
eBook ISBN: 9780124051805
Imprint: Academic Press
Published Date: 11th December 2012
Page Count: 416
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Table of Contents

Series Page


Chapter One. Neuromodulation

1 Introduction

Chapter Two. Computational Models of Neuromodulation

1 Introduction

2 Foundations of Neurostimulation Modeling

3 Stimulation Safety

4 Spinal Cord Stimulation for Pain

5 Deep Brain Stimulation for Parkinson’s Disease

6 Limitations of Computational Models

7 Conclusions


Chapter Three. Neurophysiology of Deep Brain Stimulation

1 Electric Field and Charge Distribution

2 A Tool for Understanding the Functions of Human Deep Brain Structures

3 Neurophysiology

4 Behavioral Neurophysiology

5 Neurochemistry

6 Future Perspectives: Development of New Adaptive Deep Brain Stimulation (aDBS) Systems


Chapter Four. Neurophysiology of Cortical Stimulation

1 Introduction

2 Basic Principles of TMS

3 Repetitive Transcranial Magnetic Stimulation

4 Theta Burst Stimulation

5 Paired Associative Stimulation

6 Transcranial Electrical Stimulation with Pulsed Currents

7 Transcranial Direct Current Stimulation

8 Implanted Cortical Stimulation

9 Induced Currents into the Brain

10 Comparisons Between the Methods of Stimulation

11 Safety and Contraindications

12 Neural Circuit Activation by Cortical Stimulation: Spatial Aspects

13 Neural Circuit Activation by Cortical Stimulation: Temporal Aspects

14 Plasticity and Priming

15 Neuroprotection

16 General Principles of the Therapeutic Efficacy of Cortical Stimulation

17 Conclusion


Chapter Five. Neural Mechanisms of Spinal Cord Stimulation

1 Introduction

2 Neuropathic Pain

3 Peripheral Vascular Disease

4 Visceral Diseases

5 Cardiac Diseases

6 Conclusions


Further Reading

Chapter Six. Magnetoencephalography and Neuromodulation

1 Introduction

2 MEG and TMS

3 MEG and Transcranial Direct or Alternate Current Stimulation

4 MEG and DBS

5 Conclusions and Outlook


Chapter Seven. Current Challenges to the Clinical Translation of Brain Machine Interface Technology

1 Introduction and Motivation

2 Device Hardware

3 Performance

4 Surgical Considerations

5 Conclusion


Further Reading

Chapter Eight. Nanotechnology in Neuromodulation

1 Introduction

2 Nanotechniques: Scale and Properties

3 Fabricating Nanoelectrodes for Neuromodulation

4 Neurochemical/Neurotransmitter Monitoring

5 Computational Models and Nanoelectrodes

6 Minimally Invasive Neuromodulation

7 Nanopower to the Neuromodulators!

8 Nanoneuromodulation


Chapter Nine. Optogenetic Neuromodulation

1 Introduction

2 Basics of Optogenetics

3 Clinical Insights from Optogenetics

4 Translational Optogenetics

5 Conclusions


Chapter Ten. Diffusion Tensor Imaging and Neuromodulation

1 Overview

2 Diffusion Weighted and Diffusion Tensor Magnetic Resonance Imaging

3 Fiber Tractography

4 Deterministic and Probabilistic Fiber Tracking

5 Accuracy of Diffusion Tensor Imaging Fibertracking and Its Use in Neurosurgery

6 Electric Field Simulation

7 Applications

8 Development of a New Target Region Utilizing the DTI Technique: A New DBS Target to Treat Major Depression

9 DTI FT and the Concept of Network Balances

10 Summary


Further Reading

Chapter Eleven. Multimodal Imaging and Image Analysis Techniques for Neuromodulation

1 Introduction

2 Digital Atlases of Subcortical Structures

3 Anatomical Image Acquisition Techniques for Planning DBS Procedures

4 Functional Magnetic Resonance Imaging for Planning DBS Procedures

5 Future Perspectives and Multimodal Integration


Chapter Twelve. DBS and Electrical Neuro-Network Modulation to Treat Neurological Disorders

1 Introduction

2 ENM in the Treatment of Chronic Pain

3 Electrical ENM Approaches to Movement Disorders

4 ENM in Epilepsy

5 Conclusions


Chapter Thirteen. Neuromodulation in Psychiatric Disorders

1 Introduction

2 Neuromodulation in Addiction

3 Neuromodulation in Alzheimer’s Disease

4 Neuromodulation in Depression

5 Neuromodulation in OCD

6 Neuromodulation in TS

7 Neuromodulation in Other Psychiatric Indications

8 Conclusion


Further Reading

Chapter Fourteen. Ethical Aspects of Neuromodulation

1 Introduction

2 Personal Integrity

3 Clinical Integrity

4 Scientific Integrity

5 Conclusion


Subject Index

Contents of Recent Volumes


This issue of International Review of Neurobiology brings together cutting-edge research on neuromodulation. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery.

Key Features

  • Brings together cutting-edge research on neuromodulation
  • Reviews current knowledge and understanding
  • Provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery


Neuroscientists, psychologists, neurologists


No. of pages:
© Academic Press 2012
11th December 2012
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Volume Editors

Clement Hamani

Clement Hamani is at Sunnybrook Research Institute, Toronto, Canada

Affiliations and Expertise

Sunnybrook Research Institute, Toronto, Canada

Elena Moro

Dr. Elena Moro graduated in Medicine at the University of Trieste (Italy) in 1989 and completed her residency in Neurology at the Catholic University in Rome (Italy) in 1996. She received her PhD in Neurosciences from the Catholic University in Rome, after having spent one and a half years in Grenoble, France (Joseph Fourier University), where she worked under the supervision of Dr. P. Pollak and Dr. A.L. Benabid. For her doctoral research Dr. Moro studied the response to levodopa and the electrical parameters of stimulation in parkinsonian patients with subthalamic nucleus deep brain stimulation. From 2000 to 2002 she moved to Milan (Italy) in order to start and develop a surgical team for Movement Disorders at the Niguarda Ca’ Granda Hospital. In 2002, she joined the Division of Neurology at the University of Toronto (Canada) as an Assistant Professor, and medical Director of the surgical program for Movement Disorders at the Toronto Western Hospital. She worked with Dr. A.M. Lozano and Dr. A.E. Lang. She was promoted to Associate Professor of Neurology of the Faculty of Medicine, University of Toronto, in 2009. In 2012 she moved to Grenoble, France, as Professor of Neurology at the Joseph Fourier University (CHU Grenoble). She is currently investigating the effects of DBS on gait in parkinsonian and dystonic patients, the role of the superior colliculus as biomarker in Parkinson’s disease and the effects of the pedunculopontine nucleus stimulation. She is also responsible of the neurology teaching for undergraduate students and residents in neurology at the Faculty of Medicine of the Joseph Fourier University. She has so far published 108 scientific papers cited in PubMed and she has been an invited speaker to more than 100 international scientific meetings.

Affiliations and Expertise

University Hospital Center of Grenoble, France