Dynemicin A, Uncialamycin and Analogues

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments.  However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis.
Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved.  This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.

• Presents two natural ènediynes with similar structures whose total syntheses have been accomplished
• Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity
• Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted
• Features studies of the biological activities and data to bring out the structural elements of these essential compounds

Undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries

• Introduction
• 1: Dynemicin A
  • Abstract:
  • 1.1 Isolation and characterization
  • 1.2 Biosynthesis
  • 1.3 Total synthesis, analogues and biological activities
• 2: Uncialamycin
  • Abstract:
  • 2.1 Isolation and characterization
  • 2.2 Biosynthesis
  • 2.3 Total synthesis and analogues
• Conclusion
• Appendix
• Bibliography
• Index