Dynamics of Bone and Cartilage Metabolism - 2nd Edition - ISBN: 9780120885626, 9780080456263

Dynamics of Bone and Cartilage Metabolism

2nd Edition

Principles and Clinical Applications

Editors: Markus Seibel Simon Robins John Bilezikian
eBook ISBN: 9780080456263
Hardcover ISBN: 9780120885626
Imprint: Academic Press
Published Date: 24th July 2006
Page Count: 920
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Description

This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases.

Key Features

  • Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components
  • Part II covers the organizational structure and cellular metabolism of bone and cartilage
  • Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Readership

Endocrinologists, bone biologists, rheumatologists, clinical biochemists, and other clinical disciplines participating in the management of the patient with bone and cartilage diseases

Table of Contents

PART I
Components of the Organic Extracellular Matrix of Bone and Cartilage

CHAPTER 1
Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone
KLAUS VON DER MARK

CHAPTER 2
Fibrillogenesis and Maturation of Collagens
SIMON P ROBINS

CHAPTER 3
Vitamin K Dependent Proteins of Bone and Cartilage
CAREN M GUNDBERG and SATORU K NISHIMOTO

CHAPTER 4
Non-collagenous Proteins; Glycoproteins and Related Proteins
DICK HEINEGÅRD, PILAR LORENZO and TORE SAXNE

CHAPTER 5
Proteoglycans and Glycosaminoglycans
TIM E HARDINGHAM

CHAPTER 6
Growth Factors
PHILIPPA A HULLEY, PETER I CROUCHER and GRAHAM G RUSSELL

CHAPTER 7
Prostaglandins and Proinflammatory Cytokines
LAWRENCE G RAISZ and JOSEPH A LORENZO

CHAPTER 8
Integrins and Other Adhesion Molecules
MIEP H HELFRICH and MICHAEL A HORTON

CHAPTER 9
Alkaline Phosphatases
JOSÉ LUIS MILLÁN

Chapter 10
Acid Phosphatases
HELENA KAIJA, LILA OT PATRIKAINEN, SARI L ALATALO, H KALERVO VAANANEN and PIRKKO T VIHKO

CHAPTER 11
Matrix Proteinases
IAN M CLARK and GILLIAN MURPHY

PART II
Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage

CHAPTER 12
Mineralization, Structure and Function of Bone
ADELE L BOSKEY

CHAPTER 13
Bone Structure and Strength
EGO SEEMAN

CHAPTER 14
The Cells of Bone
JANE B LIAN and GARY S STEIN

CHAPTER 15
Signalling in bone
T JOHN MARTIN and NATALIE A SIMS


CHAPTER 16
Parathyroid Hormone: Structure, Function and Dynamic Actions
LORRAINE A FITZPATRICK and JOHN P BILEZIKIAN

CHAPTER 17
Interaction of Parathyroid Hormone-Related Peptide with the Skeleton
DAVID GOLTZMAN

CHAPTER 18
The Vitamin D Hormone and Its Nuclear Receptor: Mechanisms Involved in Bone Biology
GEERT CARMELIET, ANNEMIEKE VERSTUYF, CHRISTA MAES, GUY EELEN and ROGER BOUILLON

CHAPTER 19
Sex Steroid Effects on Bone Metabolism
DAVID G MONROE, THOMAS C SPELSBERG and SUNDEEP KHOSLA


CHAPTER 20
Physiology of Calcium and Phosphate Homeostasis
RENÉ RIZZOLI and JEAN-PHILIPPE BONJOUR

CHAPTER 21
The Central Control of Bone Remodelling
PAUL A BALDOCK, SUSAN J ALLISON, HERBERT HERZOG and EDITH M GARDINER

CHAPTER 22
New Concepts in Bone Remodeling
DAVID W DEMPSTER and HUA ZHOU

CHAPTER 23
Products of Bone Collagen Metabolism
JUHA RISTELI and LEILA RISTELI

CHAPTER 24
Supramolecular Structure of Cartilage Matrix
PETER BRUCKNER

CHAPTER 25
Products of Cartilage Metabolism
DANIEL-HENRI MANICOURT, JEAN-PIERRE DEVOGELAER and EUGÈNE J-M A THONAR

CHAPTER 26
Fluid Dynamics of the Joint Space and Trafficking of Matrix Products
PETER A SIMKIN

CHAPTER 27
Transgenic Models of Bone Disease
BARBARA E KREAM and JOHN R HARRISON


PART III
Markers of Bone and Cartilage Metabolism

Quantification: Technical Aspects

CHAPTER 28
The Role of Genetic Variation in Osteoporosis
ANDRÉ G UITTERLINDEN, Joyce B J van Meurs, Fernando Rivadeneira, JOHANNES P T M VAN LEEUWEN and HUIBERT A P POLS

CHAPTER 29
Measurement of Calcium, Phosphate and Magnesium
HEINRICH SCHMIDT-GAYK

Chapter 30
Measurement of Parathyroid Hormone
HARALD JÜPPNER and GHADA EL-HAJJ FULEIHAN

Chapter 31
New Horizons for Assessment of Vitamin D Status in Man
GARY L LENSMEYER, NEIL BINKLEY and MARC K. DREZNER

CHAPTER 32
Measurement of Biochemical Markers of Bone Formation
KIM E NAYLOR and RICHARD EASTELL

CHAPTER 33
Measurement of Biochemical Markers of Bone Resorption
MARIUS E KRAENZLIN and MARKUS J SEIBEL

CHAPTER 34
Variability in the measurement of biochemical markers of bone turnover
TUAN V. NGUYEN, CHRISTIAN MEIER AND MARKUS J. SEIBEL

CHAPTER 35
Validation of Biochemical Markers of Bone Turnover
KIM BRIXEN and ERIK F ERIKSEN

CHAPTER 36
Genetic Markers of Joint Disease
MICHEL NEIDHART, RENATE E GAY and STEFFEN GAY

CHAPTER 37
Body Fluid Markers of Cartilage Metabolism
EUGÈNE J-M A THONAR, MARY ELLEN LENZ, KOICHI MASUDA and DANIEL-HENRI MANICOURT

Clinical Applications

CHAPTER 38
Laboratory Assessment of Postmenopausal Osteoporosis
PATRICK GARNERO and PIERRE D DELMAS

CHAPTER 39
Monitoring of Anabolic Treatment
JOHN P BILEZIKIAN and MISHAELA R RUBIN

CHAPTER 40
Monitoring of anti-resorptive treatment
CHRISTIAN MEIER, TUAN NGYEN and MARKUS J SEIBEL, Sydney, Australia

CHAPTER 41
Age-Related Osteoporosis and Skeletal Markers of Bone Turnover
CLIFFORD J ROSEN

CHAPTER 42
Osteoporosis in Men
ERIC S. ORWOLL and JEAN-MARC KAUFMAN

CHAPTER 43
Steroid-Induced Osteoporosis
IAN R REID

CHAPTER 44
Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment
CAROLINA A MOREIRA KULAK and ELIZABETH SHANE

CHAPTER 45
Secondary Osteoporosis
JEAN E MULDER, CAROLINA A MOREIRA KULAK and ELIZABETH SHANE

CHAPTER 46
Osteomalacia and Rickets
MARC K DREZNER

CHAPTER 47
Assessment of Bone and Joint Diseases: Renal Osteodystrophy
ESTHER A GONZÁLEZ, ZIYAD AL ALY and KEVIN J MARTIN

CHAPTER 48
Primary Hyperparathyroidism
SHONNI J SILVERBERG and JOHN P BILEZIKIAN

CHAPTER 49
Paget’s Disease of Bone
ANDREAS GRAUER, ETHEL SIRIS and STUART RALSTON

CHAPTER 50
Metastatic Bone Disease
JEAN-JACQUES BODY

CHAPTER 51
Rare Bone Diseases
MICHAEL P WHYTE

CHAPTER 52
Osteogenesis Imperfecta
FRANCIS H. GLORIEUX and FRANK RAUCH

CHAPTER 53
Rheumatoid Arthritis and Other Inflammatory Joint Pathologies
STEVEN R GOLDRING and MARY B GOLDRING

CHAPTER 54
Osteoarthritis and Degenerative Spine Pathologies
KRISTINA ÅKESSON

Details

No. of pages:
920
Language:
English
Copyright:
© Academic Press 2006
Published:
Imprint:
Academic Press
eBook ISBN:
9780080456263
Hardcover ISBN:
9780120885626

About the Editor

Markus Seibel

Markus J. Seibel completed a medical degree and a doctoral degree in 1984 from the University of Mainz, Germany and the University of Pennsylvania, Philadelphia. Since 1996, he has been the head of the Endocrine Laboratories at Heidelberg University, Germany and a consultant in Endocrinology. Since 1997, he has been an Associate Professor and Member of the Faculty of Medicine at the University of Heidelberg and as of 1999, he will be Associate to the Director of the Department of Endocrinology and Metabolism. His research interests include bone and cartilage metabolism, treatment of osteoporosis, and thyroid carcinoma.

Affiliations and Expertise

Concord Hospital, University of Sydney, Australia Director, Department of Endocrinology and Metabolism, Concord Hospital Medical Center; Professor and Chair of Endocrinology, The University of Sydney and Head

Simon Robins

Affiliations and Expertise

Rowett Research Institute, Aberdeen, U.K.

John Bilezikian

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and Expertise

Columbia University, New York, New York, U.S.A.

Reviews

Praise for the First Edition:
"..The approach taken in this book--to consider the structural, functional, metabolic, and pathologic aspects of bone and cartilage in parallel--is a welcome departure and provides the reader with an unusual and interesting range of topics...Scientists and physicians who wish to cross the divide between bone and cartilage will find this book of considerable interest and value..." --Juliet E. Compston, University of Cambridge, UK in THE NEW ENGLAND JOURNAL OF MEDICINE