Dynamics of Bone and Cartilage Metabolism - 2nd Edition - ISBN: 9780120885626, 9780080456263

Dynamics of Bone and Cartilage Metabolism

2nd Edition

Principles and Clinical Applications

Editors: Markus Seibel Simon Robins John Bilezikian
Hardcover ISBN: 9780120885626
eBook ISBN: 9780080456263
Imprint: Academic Press
Published Date: 24th July 2006
Page Count: 920
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Description

This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, this latest edition is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases.

Key Features

Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage *Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Readership

Endocrinologists, bone biologists, rheumatologists, clinical biochemists, and other clinical disciplines participating in the management of the patient with bone and cartilage diseases

Table of Contents

Table of contents (in progress)

PART I Components of the Organic Extracellular Matrix of Bone and Cartilage

CHAPTER 1 Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone KLAUS VON DER MARK

CHAPTER 2 Fibrillogenesis and Maturation of Collagens SIMON P ROBINS

CHAPTER 3 Vitamin K Dependent Proteins of Bone and Cartilage CAREN M GUNDBERG and SATORU K NISHIMOTO

CHAPTER 4 Non-collagenous Proteins; Glycoproteins and Related Proteins DICK HEINEGÅRD, PILAR LORENZO and TORE SAXNE

CHAPTER 5 Proteoglycans and Glycosaminoglycans TIM E HARDINGHAM

CHAPTER 6 Growth Factors PHILIPPA A HULLEY, PETER I CROUCHER and GRAHAM G RUSSELL

CHAPTER 7 Prostaglandins and Proinflammatory Cytokines LAWRENCE G RAISZ and JOSEPH A LORENZO

CHAPTER 8 Integrins and Other Adhesion Molecules MIEP H HELFRICH and MICHAEL A HORTON

CHAPTER 9 Alkaline Phosphatases JOSÉ LUIS MILLÁN

Chapter 10 Acid Phosphatases HELENA KAIJA, LILA OT PATRIKAINEN, SARI L ALATALO, H KALERVO VAANANEN and PIRKKO T VIHKO

CHAPTER 11 Matrix Proteinases IAN M CLARK and GILLIAN MURPHY

PART II Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage

CHAPTER 12 Mineralization, Structure and Function of Bone ADELE L BOSKEY

CHAPTER 13 Bone Structure and Strength EGO SEEMAN

CHAPTER 14 The Cells of Bone JANE B LIAN and GARY S STEIN

CHAPTER 15 Signalling in bone T JOHN MARTIN and NATALIE A SIMS

CHAPTER 16 Parathyroid Hormone: Structure, Function and Dynamic Actions LORRAINE A FITZPATRICK and JOHN P BILEZIKIAN

CHAPTER 17 Interaction of Parathyroid Hormone-Related Peptide with the Skeleton DAVID GOLTZMAN

CHAPTER 18 The Vitamin D Hormone and Its Nuclear Receptor: Mechanisms Involved in Bone Biology GEERT CARMELIET, ANNEMIEKE VERSTUYF, CHRISTA MAES, GUY EELEN and ROGER BOUILLON

CHAPTER 19 Sex Steroid Effects on Bone Metabolism DAVID G MONROE, THOMAS C SPELSBERG and SUNDEEP KHOSLA

CHAPTER 20 Physiology of Calcium and Phosphate Homeostasis RENÉ RIZZOLI and JEAN-PHILIPPE BONJOUR

CHAPTER 21 The Central Control of Bone Remodelling PAUL A BALDOCK, SUSAN J ALLISON, HERBERT HERZOG and EDITH M GARDINER

CHAPTER 22 New Concepts in Bone Remodeling DAVID W DEMPSTER and HUA ZHOU

CHAPTER 23 Products of Bone Collagen Metabolism JUHA RISTELI and LEILA RISTELI

CHAPTER 24 Supramolecular Structure of Cartilage Matrix PETER BRUCKNER

CHAPTER 25 Products of Cartilage Metabolism DANIEL-HENRI MANICOURT, JEAN-PIERRE DEVOGELAER and EUGÈNE J-M A THONAR

CHAPTER 26 Fluid Dynamics of the Joint Space and Trafficking of Matrix Products PETER A SIMKIN

CHAPTER 27 Transgenic Models of Bone Disease BARBARA E KREAM and JOHN R HARRISON

PART III Markers of Bone and Cartilage Metabolism

Quantification: Technical Aspects

CHAPTER 28 The Role of Genetic Variation in Osteoporosis ANDRÉ G UITTERLINDEN, Joyce B J van Meurs, Fernando Rivadeneira, JOHANNES P T M VAN LEEUWEN and HUIBERT A P POLS

CHAPTER 29 Measurement of Calcium, Phosphate and Magnesium HEINRICH SCHMIDT-GAYK

Chapter 30 Measurement of Parathyroid Hormone HARALD JÜPPNER and GHADA EL-HAJJ FULEIHAN

Chapter 31 New Horizons for Assessment of Vitamin D Status in Man GARY L LENSMEYER, NEIL BINKLEY and MARC K. DREZNER

CHAPTER 32 Measurement of Biochemical Markers of Bone Formation KIM E NAYLOR and RICHARD EASTELL

CHAPTER 33 Measurement of Biochemical Markers of Bone Resorption MARIUS E KRAENZLIN and MARKUS J SEIBEL

CHAPTER 34 Variability in the measurement of biochemical markers of bone turnover TUAN V. NGUYEN, CHRISTIAN MEIER AND MARKUS J. SEIBEL

CHAPTER 35 Validation of Biochemical Markers of Bone Turnover KIM BRIXEN and ERIK F ERIKSEN

CHAPTER 36 Genetic Markers of Joint Disease MICHEL NEIDHART, RENATE E GAY and STEFFEN GAY

CHAPTER 37 Body Fluid Markers of Cartilage Metabolism EUGÈNE J-M A THONAR, MARY ELLEN LENZ, KOICHI MASUDA and DANIEL-HENRI MANICOURT

Clinical Applications

CHAPTER 38 Laboratory Assessment of Postmenopausal Osteoporosis PATRICK GARNERO and PIERRE D DELMAS

CHAPTER 39 Monitoring of Anabolic Treatment JOHN P BILEZIKIAN and MISHAELA R RUBIN

CHAPTER 40 Monitoring of anti-resorptive treatment CHRISTIAN MEIER, TUAN NGYEN and MARKUS J SEIBEL, Sydney, Australia

CHAPTER 41 Age-Related Osteoporosis and Skeletal Markers of Bone Turnover CLIFFORD J ROSEN

CHAPTER 42 Osteoporosis in Men
ERIC S. ORWOLL and JEAN-MARC KAUFMAN

CHAPTER 43 Steroid-Induced Osteoporosis IAN R REID

CHAPTER 44 Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment CAROLINA A MOREIRA KULAK and ELIZABETH SHANE

CHAPTER 45 Secondary Osteoporosis JEAN E MULDER, CAROLINA A MOREIRA KULAK and ELIZABETH SHANE

CHAPTER 46 Osteomalacia and Rickets MARC K DREZNER

CHAPTER 47 Assessment of Bone and Joint Diseases: Renal Osteodystrophy ESTHER A GONZÁLEZ, ZIYAD AL ALY and KEVIN J MARTIN

CHAPTER 48 Primary Hyperparathyroidism SHONNI J SILVERBERG and JOHN P BILEZIKIAN

CHAPTER 49 Paget’s Disease of Bone ANDREAS GRAUER, ETHEL SIRIS and STUART RALSTON

CHAPTER 50 Metastatic Bone Disease JEAN-JACQUES BODY

CHAPTER 51 Rare Bone Diseases MICHAEL P WHYTE

CHAPTER 52 Osteogenesis Imperfecta FRANCIS H. GLORIEUX and FRANK RAUCH

CHAPTER 53 Rheumatoid Arthritis and Other Inflammatory Joint Pathologies STEVEN R GOLDRING and MARY B GOLDRING

CHAPTER 54 Osteoarthritis and Degenerative Spine Pathologies KRISTINA ÅKESSON

Details

No. of pages:
920
Language:
English
Copyright:
© Academic Press 2006
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780120885626
eBook ISBN:
9780080456263

About the Editor

Markus Seibel

Markus J. Seibel completed a medical degree and a doctoral degree in 1984 from the University of Mainz, Germany and the University of Pennsylvania, Philadelphia. Since 1996, he has been the head of the Endocrine Laboratories at Heidelberg University, Germany and a consultant in Endocrinology. Since 1997, he has been an Associate Professor and Member of the Faculty of Medicine at the University of Heidelberg and as of 1999, he will be Associate to the Director of the Department of Endocrinology and Metabolism. His research interests include bone and cartilage metabolism, treatment of osteoporosis, and thyroid carcinoma.

Affiliations and Expertise

Concord Hospital, University of Sydney, Australia Director, Department of Endocrinology and Metabolism, Concord Hospital Medical Center; Professor and Chair of Endocrinology, The University of Sydney and Head

Simon Robins

Affiliations and Expertise

Rowett Research Institute, Aberdeen, U.K.

John Bilezikian

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and Expertise

Columbia University, New York, New York, U.S.A.

Reviews

Praise for the First Edition: "..The approach taken in this book--to consider the structural, functional, metabolic, and pathologic aspects of bone and cartilage in parallel--is a welcome departure and provides the reader with an unusual and interesting range of topics...Scientists and physicians who wish to cross the devide between bone and cartilage will find this book of considerable interest and value..." @source:Juliet E. Compston, University of Cambridge, UK in THE NEW ENGLAND JOURNAL OF MEDICINE