This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, this latest edition is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases.
Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage *Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease
Endocrinologists, bone biologists, rheumatologists, clinical biochemists, and other clinical disciplines participating in the management of the patient with bone and cartilage diseases
Table of contents (in progress)
PART I Components of the Organic Extracellular Matrix of Bone and Cartilage
CHAPTER 1 Structure, Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone KLAUS VON DER MARK
CHAPTER 2 Fibrillogenesis and Maturation of Collagens SIMON P ROBINS
CHAPTER 3 Vitamin K Dependent Proteins of Bone and Cartilage CAREN M GUNDBERG and SATORU K NISHIMOTO
CHAPTER 4 Non-collagenous Proteins; Glycoproteins and Related Proteins DICK HEINEGÅRD, PILAR LORENZO and TORE SAXNE
CHAPTER 5 Proteoglycans and Glycosaminoglycans TIM E HARDINGHAM
CHAPTER 6 Growth Factors PHILIPPA A HULLEY, PETER I CROUCHER and GRAHAM G RUSSELL
CHAPTER 7 Prostaglandins and Proinflammatory Cytokines LAWRENCE G RAISZ and JOSEPH A LORENZO
CHAPTER 8 Integrins and Other Adhesion Molecules MIEP H HELFRICH and MICHAEL A HORTON
CHAPTER 9 Alkaline Phosphatases JOSÉ LUIS MILLÁN
Chapter 10 Acid Phosphatases HELENA KAIJA, LILA OT PATRIKAINEN, SARI L ALATALO, H KALERVO VAANANEN and PIRKKO T VIHKO
CHAPTER 11 Matrix Proteinases IAN M CLARK and GILLIAN MURPHY
PART II Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage
CHAPTER 12 Mineralization, Structure and Function of Bone ADELE L BOSKEY
CHAPTER 13 B
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- © Academic Press 2006
- 24th July 2006
- Academic Press
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Markus J. Seibel completed a medical degree and a doctoral degree in 1984 from the University of Mainz, Germany and the University of Pennsylvania, Philadelphia. Since 1996, he has been the head of the Endocrine Laboratories at Heidelberg University, Germany and a consultant in Endocrinology. Since 1997, he has been an Associate Professor and Member of the Faculty of Medicine at the University of Heidelberg and as of 1999, he will be Associate to the Director of the Department of Endocrinology and Metabolism. His research interests include bone and cartilage metabolism, treatment of osteoporosis, and thyroid carcinoma.
Concord Hospital, University of Sydney, Australia Director, Department of Endocrinology and Metabolism, Concord Hospital Medical Center; Professor and Chair of Endocrinology, The University of Sydney and Head
Rowett Research Institute, Aberdeen, U.K.
John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and
Columbia University, New York, New York, U.S.A.
Praise for the First Edition: "..The approach taken in this book--to consider the structural, functional, metabolic, and pathologic aspects of bone and cartilage in parallel--is a welcome departure and provides the reader with an unusual and interesting range of topics...Scientists and physicians who wish to cross the devide between bone and cartilage will find this book of considerable interest and value..." @source:Juliet E. Compston, University of Cambridge, UK in THE NEW ENGLAND JOURNAL OF MEDICINE