Drugs and the Cell Cycle

1st Edition - January 1, 1973
Editor: A Zimmerman
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 5 0 1 - 4

Drugs and the Cell Cycle provides an introduction to fundamental principles and studies on the mechanisms of drug action on proliferating cells. The book is intended to reduce the… Read more

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Drugs and the Cell Cycle provides an introduction to fundamental principles and studies on the mechanisms of drug action on proliferating cells. The book is intended to reduce the time lag between observation and practical application. Comprised of 10 chapters, the book describes the plant alkaloids, alkylating agents, mercurials, adrenergic agents, radiomimetics, narcotics, hallucinogens, mitogens, hepatotoxins, antiobiotics, and antimetabolites of various types. The text also emphasizes the drugs used in cancer chemotherapy, and the in vitro and in vivo cell systems of bacteria, protozoa, sea urchins, and mammals. The concepts are presented with comprehensive illustrations and tables to help readers obtain more efficient understanding and learning. The information and concepts presented in this volume will be of great interest to scientists and students in many disciplines, including physiology, pharmacology, and oncology, as well as cellular, molecular, and developmental biology. The book will also fill the gap between drug experimental observations and their potential relevance to man.

List of Contributors

Preface

1 Perspectives on Drugs and the Cell Cycle

I. Chemotherapy and the Cell Cycle

II. The Cell Cycle as a Sensitive Indicator for Drug Analysis

References

2 Macromolecular Assembly Inhibitors and Their Action on the Cell Cycle

I. Introduction

II. Colchicine

III. Vinblastine

IV. Cytochalasin and Microfilaments

References

3 The Effect of Mercuric Compounds on Dividing Cells

I. Introduction

II. Mercaptide Formation by Mercurials

III. Production of c-Mitotic Figures by Organomercurials

IV. Mercuric Compounds and the Generation Time, DNA and Protein Synthesis, the Cell Cycle, and Cilia Regeneration in Tetrahymena pyriformis

V. Distribution of 3H-Methylmercuric Chloride in Fertilized Eggs of Lytechinus pictus

VI. Observations on the Structural Organization of Tetrahymena pyriformis Treated with Mercuric Chloride

VII. Concluding Remarks

References

4 Adrenergic Drugs on the Cell Cycle

I. Introduction

II. Experimental Results

III. Discussion and Summary

References

5 Action of Narcotic and Hallucinogenic Agents on the Cell Cycle

I. Introduction

II. The Chemistry of Selected Drugs

III. Action of Drugs on Prokaryotic Cells

IV. Action of Drugs on Eukaryotic Cells

V. Present Studies on Tetrahymena

VI. Concluding Remarks

References

6 Effects of Drugs on Hepatic Cell Proliferation

Abbreviations

I. Introduction

II. Kinetics of Hepatic Cell Proliferation

III. Regulation of Hepatic Cell Proliferation

IV. Drugs and Hepatic Cell Proliferation

V. Concluding Remarks

References

7 Effects of Mitogens on the Mitotic Cycle: A Biochemical Evaluation of Lymphocyte Activation

I. Introduction

II. Background: Peripheral Blood Lymphocytes

III. Nature of Mitogenic Substances

IV. General Characteristics of Mitogen-Induced Lymphocyte Growth

V. Biochemical Events in Lymphocyte Transformation

VI. Discussion and Conclusions

References

8 Intestinal Cytodynamics: Adductions from Drug Radiation Studies

I. Introduction

II. Nature of the Crypt Progenitor Cell

III. Factors Influencing Intestinal Tolerance to Cytotoxins

IV. Control Aspects of Intestinal Cell Renewal

V. Summary

References

9 The Effects of Antitumor Drugs on the Cell Cycle

I. Introduction

II. Antitumor Drugs

III. General Discussion

IV. Summary

References

10 Effects of Purines, Pyrimidines, Nucleosides, and Chemically Related Compounds on the Cell Cycle

I. Introduction

II. Biochemical Mechanisms of Agents

III. Effect of Agents on Cells

IV. Correlation of Biochemical Effects and Effects on the Cell Cycle

V. Examples of the Logic and Use of These Agents for Cancer Chemotherapy

VI. Concluding Comments

References

Author Index

Subject Index