Drugs and the Cell Cycle provides an introduction to fundamental principles and studies on the mechanisms of drug action on proliferating cells. The book is intended to reduce the time lag between observation and practical application.
Comprised of 10 chapters, the book describes the plant alkaloids, alkylating agents, mercurials, adrenergic agents, radiomimetics, narcotics, hallucinogens, mitogens, hepatotoxins, antiobiotics, and antimetabolites of various types. The text also emphasizes the drugs used in cancer chemotherapy, and the in vitro and in vivo cell systems of bacteria, protozoa, sea urchins, and mammals. The concepts are presented with comprehensive illustrations and tables to help readers obtain more efficient understanding and learning.
The information and concepts presented in this volume will be of great interest to scientists and students in many disciplines, including physiology, pharmacology, and oncology, as well as cellular, molecular, and developmental biology. The book will also fill the gap between drug experimental observations and their potential relevance to man.
List of Contributors Preface 1 Perspectives on Drugs and the Cell Cycle I. Chemotherapy and the Cell Cycle II. The Cell Cycle as a Sensitive Indicator for Drug Analysis References 2 Macromolecular Assembly Inhibitors and Their Action on the Cell Cycle I. Introduction II. Colchicine III. Vinblastine IV. Cytochalasin and Microfilaments References 3 The Effect of Mercuric Compounds on Dividing Cells I. Introduction II. Mercaptide Formation by Mercurials III. Production of c-Mitotic Figures by Organomercurials IV. Mercuric Compounds and the Generation Time, DNA and Protein Synthesis, the Cell Cycle, and Cilia Regeneration in Tetrahymena pyriformis V. Distribution of 3H-Methylmercuric Chloride in Fertilized Eggs of Lytechinus pictus VI. Observations on the Structural Organization of Tetrahymena pyriformis Treated with Mercuric Chloride VII. Concluding Remarks References 4 Adrenergic Drugs on the Cell Cycle I. Introduction II. Experimental Results III. Discussion and Summary References 5 Action of Narcotic and Hallucinogenic Agents on the Cell Cycle I. Introduction II. The Chemistry of Selected Drugs III. Action of Drugs on Prokaryotic Cells IV. Action of Drugs on Eukaryotic Cells V. Present Studies on Tetrahymena VI. Concluding Remarks References 6 Effects of Drugs on Hepatic Cell Proliferation Abbreviations I. Introduction II. Kinetics of Hepatic Cell Proliferation III. Regulation of Hepatic Cell Proliferation IV. Drugs and Hepatic Cell Proliferation V. Concluding Remarks References 7 Effects of Mitogens on the Mitotic Cycle: A Biochemical Evaluation of Lymphocyte Activation I. Introduction II. Background: Peripheral Blood Lymphocytes III. Nature of Mitogenic Substances IV. General Characteristics of Mitogen-Induced Lymphocyte Growth
- No. of pages:
- © Academic Press 1973
- 1st January 1973
- Academic Press
- eBook ISBN: