This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.


Biochemists, molecular biologists, pharmacologists, biophysicists, geneticists, and cell biologists.

Table of Contents

Contributors to Volume 340. Preface. Volume in Series. Section I. Biophysical Approaches Analysis and Interpretations of Ligand-DNA Binding Isotherms, J.B. Chaires. Surface Plasmon Resonance Biosensor Analysis of RNA-Small Molecule Interactions, T.M. Davis, and W.D. Wilson. Simultaneous Measurement of Binding Constants and Unwinding Angles by Gel Eletrophoresis, S.M. Zeman and D.M. Crothers. Linear and Circular Dichroism of Drug-Nucleic Acid Complexes, M. Eriksson, and B. Norden. Rapid Screening of Structurally Selective Ligand Binding to Nucleic Acids, J. Ren, and J.B. Chaires. Calorimetric Techniques in the Study of High-Order DNA-Drug Interactions, I. Haq, B.Z. Chowdhry, and T.C. Jenkins. Volume Changes Accompanying Interactions of Ligands with Nucleic Acids, L.A. Marky, D.W. Kupke, and B.I. Kankia. Calculating Sequence-Dependent Melting Stability of Duplex DNA Oligomers and Multiplex Sequence Analysis by Graphs, A.S. Benight, P. Pancoska, R. Owczarzy, P.M. Vallone, J. Nesetril, and P.V. Riccelli. Thermal Denaturation as Tool to Study DNA-Ligan Interaction, C.H. Spink, and S.E. Wellman. Kinetics of Binding of Hoechst Dyes to DNA Studied by Stopped-Flow Fluorescence Techniques, S.Y. Breusegem, F.G. Loontiens, P. Regenfuss, and R.M. Clegg. Scanning Force Microscopy of Nucleic Acid Complexes, P.T. Lillehei, and L.A. Bottomley. Nuclear Magnetic Resonance Studies of Drug-DNA Complexes in Solution, A.N. Lane. X-Ray Crystallography of DNA-Drug Complexes, M.E. Peek, and L.D. Williams. Molecular Modeling of Drug-DNA Complexes: An Update, J.O. Trent. Chemical and Molecular Biological Approaches


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© 2001
Academic Press
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About the serial-volume-editors

Jonathan Chaires

Affiliations and Expertise

University of Mississippi Medical Center, Jackson, U.S.A.

Michael Waring

Affiliations and Expertise

University of Cambridge, U.K.


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