Drug Metabolism in Diseases - 1st Edition - ISBN: 9780128029497, 9780128029633

Drug Metabolism in Diseases

1st Edition

Editors: Wen Xie
eBook ISBN: 9780128029633
Hardcover ISBN: 9780128029497
Imprint: Academic Press
Published Date: 23rd September 2016
Page Count: 294
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Description

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states.

Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology.

Key Features

  • Written and edited by leaders in drug metabolism from academia and industry
  • Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more
  • Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Readership

Academic researchers involved in drug metabolism, pharmacology, molecular pharmacology, clinical pharmacology and personalized medicine; industry researchers working in drug metabolism, drug toxicity and drug safety evaluation; and regulatory officials in drug safety

Table of Contents

  • Preface
  • Chapter 1. Introduction of Drug Metabolism and Overview of Disease Effect on Drug Metabolism
    • Introduction
    • Overview of Drug Metabolism
    • Disease Effects on Drug Metabolism
    • Disease Effects on Absorption Parameters
    • Changes in Blood Flow to Organs
    • Changes in Protein Binding
    • Disease Effects on Transporter Expression
    • Summary
  • Chapter 2. Regulation of Drug-Metabolizing Enzymes and Drug Metabolism by Inflammatory Responses
    • Introduction
    • The Inflammatory Response
    • Regulation of DMEs by Inflammatory Mediators
    • Regulation of P450 Enzymes in Specific Disease States and Models
    • Disease-Dependent Drug–Drug Interactions
    • Mechanisms of Regulation
    • Conclusion
  • Chapter 3. Regulation of Drug Transporters by Inflammation
    • Introduction
    • Acute Inflammation
    • Models of Acute Inflammation
    • Effect of Acute Inflammation on Drug Transporters
    • Chronic Inflammation
    • Impact of Chronic Inflammation on Drug Transporters
    • Conclusion
  • Chapter 4. Drug Metabolism in Kidney Disease
    • Conventional Drug-Dosing Paradigm in Kidney Disease
    • Nonrenal Clearance
    • Influence of Experimental Kidney Disease on Drug Metabolism
    • Influence of Kidney Disease on Drug Metabolism in Humans
    • Mechanisms of Altered Drug Metabolism in Kidney Disease
    • Summary
  • Chapter 5. Drug and Fatty Acid Cytochrome P450 Metabolism in Critical Care
    • Introduction
    • Stroke
    • Traumatic Brain Injury
    • Cardiac Arrest
    • Summary
  • Chapter 6. Drug Metabolism in Cardiovascular Disease
    • Introduction
    • Cardiovascular Diseases
    • Cytochrome P-450 Expression in Cardiovascular Disease
    • Pharmacogenomics Related to Cardiovascular Drugs and Disease
    • Conclusion
  • Chapter 7. Pharmacogenetic Factors That Affect Drug Metabolism and Efficacy in Type 2 Diabetes Mellitus
    • Introduction
    • Sulfonylureas
    • Meglitinides
    • Metformin
    • Thiazolidinediones
    • α-Glucosidase Inhibitors
    • DPP-4 Inhibitors
    • Conclusion
  • Chapter 8. Hepatic Drug Metabolism in Pediatric Patients
    • Ontogeny of Hepatic Drug Metabolism
    • Ontogeny of Intrinsic Hepatic Clearance
    • Ontogeny of Hepatic Blood Flow
    • Ontogeny of Plasma Protein Binding
    • Ontogeny of Hepatic Drug Transporters
    • Conclusion
  • Chapter 9. Drug Metabolism in Pregnancy
    • Introduction
    • Physiological Adaptations During Pregnancy
    • Hepatic Phase I Enzymes
    • Hepatic Phase II Enzymes
    • Hepatic Transporters
    • Nuclear Receptors
    • Hormonal Regulation
    • Extrahepatic Regulation
    • Case Example: Bile Acid Metabolism and Transport
    • Conclusion and Future Directions
  • Chapter 10. Estrogen-Metabolizing Enzymes in Systemic and Local Liver Injuries: A Case Study of Disease–Drug Interaction
    • Estrogen Sulfotransferase and Steroid Sulfatase in Estrogen Homeostasis: An Introduction
    • Estrogen Sulfotransferase and Its Regulation in Sepsis Response
    • Estrogen Sulfotransferase and Its Regulation in Liver Ischemia and Reperfusion Response
    • Steroid Sulfatase and Its Regulation in Estrogen Homeostasis and Inflammation in Chronic Liver Disease
    • Conclusions and Perspectives
  • Chapter 11. Xenobiotic Receptors in the Crosstalk Between Drug Metabolism and Energy Metabolism
    • Introduction
    • Xenobiotic Receptors as Master Regulators of Drug Metabolism
    • Drug Metabolism can be Affected by Energy Metabolism
    • Energy Metabolism can be Affected by Drug Metabolism and Xenobiotic Receptors
    • Conclusion and Perspectives
  • Index

Details

No. of pages:
294
Language:
English
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
eBook ISBN:
9780128029633
Hardcover ISBN:
9780128029497

About the Editor

Wen Xie

Professor of Pharmaceutical Sciences and Pharmacology, The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Director of the Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA

Affiliations and Expertise

Professor of Pharmaceutical Sciences and Pharmacology, The Joseph Koslow Endowed Chair in Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA; Director of the Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA