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Drug-Induced Liver Injury
- 1st Edition, Volume 85 - July 13, 2019
- Editors: Anup Ramachandran, Hartmut Jaeschke
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 6 7 5 9 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 7 3 1 7 - 6
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this… Read more
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Request a sales quoteDrug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more.
- Includes the authority and expertise of leading contributors in pharmacology
- Presents the latest release in the Advances in Pharmacology series
Investigators in neuroscience, pharmacology, neurology, psychiatry, medicine
1. Primary hepatocytes and their cultures for the testing of drug-induced liver injury
Vânia Vilas-Boas, Axelle Cooreman, Eva Gijbels, Raf Van Campenhout, Emma Gustafson, Steven Ballet, Pieter Annaert, Bruno Cogliati and Mathieu Vinken
2. Cell death in drug-induced liver injury
Andrea Iorga and Lily Dara
3. Drug-induced liver injury in obesity and nonalcoholic fatty liver disease
Julien Allard, Dounia Le Guillou, Karima Begriche and Bernard Fromenty
4. Role and mechanisms of autophagy in alcohol-induced liver injury
Xiaojuan Chao and Wen-Xing Ding
5. Mechanisms of idiosyncratic drug-induced liver injury
Jack Uetrecht
6. Idiosyncratic drug-induced liver injury in patients: detection, severity assessment, and regulatory implications
Paul B. Watkins
7. Acetaminophen hepatotoxicity: A mitochondrial perspective
Anup Ramachandran and Hartmut Jaeschke
8. Biomarkers of drug-induced liver injury
Mitchell R. McGill and Hartmut Jaeschke
9. Mechanisms and biomarkers of liver regeneration after drug-induced liver injury
Melissa M. Clemens, Mitchell R. McGill and Udayan Apte
10. Evaluation and treatment of acetaminophen toxicity
Erik S. Fisher and Steven C. Curry
- No. of pages: 288
- Language: English
- Edition: 1
- Volume: 85
- Published: July 13, 2019
- Imprint: Academic Press
- Hardback ISBN: 9780128167595
- eBook ISBN: 9780128173176
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Anup Ramachandran
Anup Ramachandran is at University of Kansas Medical Center, KS, USA
Affiliations and expertise
University of Kansas Medical Center, KS, USAHJ
Hartmut Jaeschke
Dr. Hartmut Jaeschke, PhD, is the University Distinguished Professor and Chairman of the Department of Pharmacology, Toxicology, and Therapeutics at the University of Kansas Medical Center, Kansas City, Kansas. He joined KUMC in 2006. He is a Fellow of the Academy of Toxicological Sciences and Fellow of the American Association for the Study of Liver Diseases. He has published more than 470 peer-reviewed manuscripts, invited reviews, and book chapters in the areas of liver toxicology and liver pathophysiology. He currently serves as Associate Editor for Toxicological Sciences, the inaugural Editor-in-Chief of Livers (since 2020) and is a member of 14 editorial boards. In 2019, he was the recipient of the Translational Impact Award from the Society of Toxicology. His major research interests include basic mechanisms and translational aspects of xenobiotic-induced hepatotoxicity and tissue repair with a focus on acetaminophen overdose and mechanisms of inflammatory liver injury in animal models and humans.
Affiliations and expertise
University Distinguished Professor, Pharmacology, Toxicology and Therapeutics; Department Chair, SOM-Kansas City, Pharmacology, Toxicology and Therapeutics, USARead Drug-Induced Liver Injury on ScienceDirect