Drug-Induced Liver Injury

Drug-Induced Liver Injury

1st Edition - July 13, 2019

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  • Editors: Anup Ramachandran, Hartmut Jaeschke
  • eBook ISBN: 9780128173176
  • Hardcover ISBN: 9780128167595

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Description

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more.

Key Features

  • Includes the authority and expertise of leading contributors in pharmacology
  • Presents the latest release in the Advances in Pharmacology series

Readership

Investigators in neuroscience, pharmacology, neurology, psychiatry, medicine

Table of Contents

  • 1. Primary hepatocytes and their cultures for the testing of drug-induced liver injury
    Vânia Vilas-Boas, Axelle Cooreman, Eva Gijbels, Raf Van Campenhout, Emma Gustafson, Steven Ballet, Pieter Annaert, Bruno Cogliati and Mathieu Vinken
    2. Cell death in drug-induced liver injury
    Andrea Iorga and Lily Dara
    3. Drug-induced liver injury in obesity and nonalcoholic fatty liver disease
    Julien Allard, Dounia Le Guillou, Karima Begriche and Bernard Fromenty
    4. Role and mechanisms of autophagy in alcohol-induced liver injury
    Xiaojuan Chao and Wen-Xing Ding
    5. Mechanisms of idiosyncratic drug-induced liver injury
    Jack Uetrecht
    6. Idiosyncratic drug-induced liver injury in patients: detection, severity assessment, and regulatory implications
    Paul B. Watkins
    7. Acetaminophen hepatotoxicity: A mitochondrial perspective
    Anup Ramachandran and Hartmut Jaeschke
    8. Biomarkers of drug-induced liver injury
    Mitchell R. McGill and Hartmut Jaeschke
    9. Mechanisms and biomarkers of liver regeneration after drug-induced liver injury
    Melissa M. Clemens, Mitchell R. McGill and Udayan Apte
    10. Evaluation and treatment of acetaminophen toxicity
    Erik S. Fisher and Steven C. Curry

Product details

  • No. of pages: 288
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: July 13, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128173176
  • Hardcover ISBN: 9780128167595

About the Serial Volume Editors

Anup Ramachandran

Anup Ramachandran is at University of Kansas Medical Center, KS, USA

Affiliations and Expertise

University of Kansas Medical Center, KS, USA

Hartmut Jaeschke

Hartmut Jaeschke is at University of Kansas Medical Center, KS, USA

Affiliations and Expertise

University of Kansas Medical Center, KS, USA

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