Drug-Induced Liver Disease

3rd Edition

Editors: Neil Kaplowitz Laurie DeLeve
Hardcover ISBN: 9780123878175
eBook ISBN: 9780123878182
Imprint: Academic Press
Published Date: 14th May 2013
Page Count: 776
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This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease.

Key Features

  • A multi-authored reference work written by leading clinical, academic and industry experts in drug-induced liver disease
  • Contains four new chapters on key areas in the field, including one on worldwide drug-induced liver injury networks
  • Each chapter has been updated to address the latest research and findings in the field and 16 new chapter authors have been added to this new edition
  • Includes coverage of the basic, clinical and practical aspects of drug-induced liver disease to provide the single most comprehensive reference on the subject


This reference is geared primarily towards medical specialists, including gastroenterologists, hepatologists, and pathologists, toxicologists, members of the pharmaceutical industry, and regulators.  This book also provides an extensive review of mechanisms of toxicity and of drug safety and would be an excellent reference for students of toxicology, as a secondary audience

Table of Contents


Preface to the Third Edition

List of Figures

List of Tables

List of Contributors

Part I: Mechanisms of Liver Injury

Chapter 1. Drug-Induced Liver Injury: Introduction and Overview


Clinical Overview



Drug Development

Postmarketing Monitoring



Chapter 2. Cytochrome P450 Activation of Toxins and Hepatotoxicity


Cytochrome P450 Enzymes

Contexts of Toxicity

Bioactivation Reactions

Strategies for Screening in Drug Development

The Issue of Human-Specific Metabolites



Chapter 3. Mechanistic Role of Acyl Glucuronides


Overview of Major Types of Chemical ReactivitIES of Acyl Glucuronides

Biochemical Aspects of Acyl Glucuronidation

Synthesis, Isolation, and Characterization of Acyl Glucuronides

Stability of Acyl Glucuronides

Reversible Binding of Acyl Glucuronides to Proteins

Covalent Binding of Acyl Glucuronides to Proteins

Stereochemical Aspects of Acyl Glucuronides

Predictability of the Covalent Binding of Acidic Drugs

In Vitro Reactivity Screens Utilizing Nucleophilic Trapping Agents

Potential Toxicological Significance of the Reactive Acyl Glucuronides



Chapter 4. Oxidant Stress, Antioxidant Defense, and Liver Injury


The Major Reactive Oxygen and Nitrogen Species in the Liver and their Sources

Pathophysiological Consequences of Oxidative Stress


Drug-Induced Oxidative Stress in the Liver


Chapter 5. Hepatotoxicity Due to Mitochondrial Injury


Overview of Mitochondria

Mitochondrial Permeability Transition


No. of pages:
© Academic Press 2013
Academic Press
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About the Editor

Neil Kaplowitz

Affiliations and Expertise

MD, Professor of Medicine, Chief, Division of Gastrointestinal and Liver Disease, University of Southern California, Keck School of Medicine

Laurie DeLeve

Affiliations and Expertise

MD, PhD, Professor of Medicine, Division of Gastrointestinal and Liver Diseases, University of Southern California Keck School of Medicine


"This volume is a fascinating read for toxicologists interested in liver toxicity, since it provides an up-to-date view of the many mechanisms of hepatotoxicity… a must-have book which should be kept close at hand, in which case it will be opened regularly by toxicologists concerned with the development and safe use of medications in a practical context." --The British Toxicology Society Newsletter, 2008 (Review of 2nd edition)