- Print ISBN 9780123878175
- Electronic ISBN 9780123878182
This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease.
A multi-authored reference work written by leading clinical, academic and industry experts in drug-induced liver disease.
Contains four new chapters on key areas in the field, including one on worldwide drug-induced liver injury networks.
Each chapter has been updated to address the latest research and findings in the field and 16 new chapter authors have been added to this new edition.
Includes coverage of the basic, clinical and practical aspects of drug-induced liver disease to provide the single most comprehensive reference on the subject.
This reference is geared primarily towards medical specialists, including gastroenterologists, hepatologists, and pathologists, toxicologists, members of the pharmaceutical industry, and regulators. This book also provides an extensive review of mechanisms of toxicity and of drug safety and would be an excellent reference for students of toxicology, as a secondary audience.
Preface to the Third Edition
List of Figures
List of Tables
List of Contributors
Part I: Mechanisms of Liver Injury
Chapter 1. Drug-Induced Liver Injury: Introduction and Overview
Chapter 2. Cytochrome P450 Activation of Toxins and Hepatotoxicity
Cytochrome P450 Enzymes
Contexts of Toxicity
Strategies for Screening in Drug Development
The Issue of Human-Specific Metabolites
Chapter 3. Mechanistic Role of Acyl Glucuronides
Overview of Major Types of Chemical ReactivitIES of Acyl Glucuronides
Biochemical Aspects of Acyl Glucuronidation
Synthesis, Isolation, and Characterization of Acyl Glucuronides
Stability of Acyl Glucuronides
Reversible Binding of Acyl Glucuronides to Proteins
Covalent Binding of Acyl Glucuronides to Proteins
Stereochemical Aspects of Acyl Glucuronides
Predictability of the Covalent Binding of Acidic Drugs
In Vitro Reactivity Screens Utilizing Nucleophilic Trapping Agents
Potential Toxicological Significance of the Reactive Acyl Glucuronides
Chapter 4. Oxidant Stress, Antioxidant Defense, and Liver Injury
The Major Reactive Oxygen and Nitrogen Species in the Liver and their Sources
Pathophysiological Consequences of Oxidative Stress
Drug-Induced Oxidative Stress in the Liver
Chapter 5. Hepatotoxicity Due to Mitochondrial Injury
Overview of Mitochondria
Mitochondrial Permeability Transition
"This volume is a fascinating read for toxicologists interested in liver toxicity, since it provides an up-to-date view of the many mechanisms of hepatotoxicity… a must-have book which should be kept close at hand, in which case it will be opened regularly by toxicologists concerned with the development and safe use of medications in a practical context."--The British Toxicology Society Newsletter, 2008 (Review of 2nd edition)