Drug Design - 1st Edition - ISBN: 9780120603046, 9781483216065

Drug Design

1st Edition

Medicinal Chemistry: A Series of Monographs, Vol. 4

Editors: E. J. Ariëns
eBook ISBN: 9781483216065
Imprint: Academic Press
Published Date: 1st January 1973
Page Count: 506
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Drug Design, Volume IV covers the pharmaceutical phase of drug action, with emphasis on those aspects that are of importance in the design of optimally effective drug products.
The book discusses biopharmaceutics as a basis for the design of drug products; the types and pharmacokinetics of peroral prolonged action dosage forms and parenteral prolonged action forms; and the design of topical drug products. The text also describes physical-chemical parameters which affect the bioavailability of topical drug products; the design of sunscreen preparations; as well as the clinical application of litholytic agents, which are preventive and curative drugs for nephrolithiasis. The design of biologically active nucleosides and of insecticidal chlorohydrocarbon derivatives is also encompassed.
Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.

Table of Contents

List of Contributors Preface Contents of Other Volumes Chapter 1. Biopharmaceutics as a Basis for the Design of Drug Products I. Introduction II. Biopharmaceutics—The Science of Input III. Bioavailability IV. Selection of the Route of Administration V. Getting Drugs into Solution VI. Gastrointestinal Membrane Transport VII. Getting Drugs into the Small Intestine References Chapter 2. Peroral Solid Dosage Forms with Prolonged Action I. Introduction II. Types of Peroral Prolonged Action Dosage Forms III. Evaluation of Peroral Prolonged Action Dosage Forms IV. Pharmacokinetics V. Additives VI. Manufacturing Process References Chapter 3. Parenteral Dosage Forms with Prolonged Action I. Introduction II. Types of Parenteral Prolonged Action Dosage Forms III. Evaluation of Parenteral Prolonged Action Dosage Forms References Chapter 4. Design of Topical Drug Products: Pharmaceutics I. Skin II. Dermatological Bases III. Drugs IV. Testing References Chapter 5. Design of Topical Drug Products: Biopharmaceutics I. Introduction II. Fundamentals of Drug Diffusion into Human Skin III. Optimizing Drug Availability from Topical Dosage Forms IV. Summary References Chapter 6. The Design of Sunscreen Preparations I. Introduction II. Ultraviolet Radiation III. Human Reactions to Ultraviolet Radiation IV. Sunscreen Preparations V. Multiple Action Products VI. Evaluation of Sunscreen Preparations References Chapter 7. Litholytic Agents: Preventive and Curative Drugs for Nephrolithiasis I. Introduction II. Factors Influencing Stone Formation III. Litholytic Agents IV. Possibilities for Dissolving the Four Different Types of Kidney Stones V. Clinical Application of the Litholytic Agents for the Dissolution of Kidney Stones VI. Summary


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© Academic Press 1973
Academic Press
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E. J. Ariëns

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