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Drug Design, Volume IV covers the pharmaceutical phase of drug action, with emphasis on those aspects that are of importance in the design of optimally effective drug products.
The book discusses biopharmaceutics as a basis for the design of drug products; the types and pharmacokinetics of peroral prolonged action dosage forms and parenteral prolonged action forms; and the design of topical drug products. The text also describes physical-chemical parameters which affect the bioavailability of topical drug products; the design of sunscreen preparations; as well as the clinical application of litholytic agents, which are preventive and curative drugs for nephrolithiasis. The design of biologically active nucleosides and of insecticidal chlorohydrocarbon derivatives is also encompassed.
Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.
List of Contributors
Contents of Other Volumes
Chapter 1. Biopharmaceutics as a Basis for the Design of Drug Products
II. Biopharmaceutics—The Science of Input
IV. Selection of the Route of Administration
V. Getting Drugs into Solution
VI. Gastrointestinal Membrane Transport
VII. Getting Drugs into the Small Intestine
Chapter 2. Peroral Solid Dosage Forms with Prolonged Action
II. Types of Peroral Prolonged Action Dosage Forms
III. Evaluation of Peroral Prolonged Action Dosage Forms
VI. Manufacturing Process
Chapter 3. Parenteral Dosage Forms with Prolonged Action
II. Types of Parenteral Prolonged Action Dosage Forms
III. Evaluation of Parenteral Prolonged Action Dosage Forms
Chapter 4. Design of Topical Drug Products: Pharmaceutics
II. Dermatological Bases
Chapter 5. Design of Topical Drug Products: Biopharmaceutics
II. Fundamentals of Drug Diffusion into Human Skin
III. Optimizing Drug Availability from Topical Dosage Forms
Chapter 6. The Design of Sunscreen Preparations
II. Ultraviolet Radiation
III. Human Reactions to Ultraviolet Radiation
IV. Sunscreen Preparations
V. Multiple Action Products
VI. Evaluation of Sunscreen Preparations
Chapter 7. Litholytic Agents: Preventive and Curative Drugs for Nephrolithiasis
II. Factors Influencing Stone Formation
III. Litholytic Agents
IV. Possibilities for Dissolving the Four Different Types of Kidney Stones
V. Clinical Application of the Litholytic Agents for the Dissolution of Kidney Stones
Chapter 8. The Design of Biologically Active Nucleosides
II. Functional Considerations
III. Structural Considerations
IV. Approaches toward Enhancing the Biological Activity of Nucleoside Analogs
V. The Mode of Action of Nucleosides in Relation to Their Structure
Chapter 9. The Design of Insecticidal Chlorohydrocarbon Derivatives
II. Physical and Chemical Toxicants
III. Aromatic Chlorohydrocarbon Insecticides: DDT Group
IV. Chlorohydrocarbon Insecticides Derived from Reduced Cyclic Systems
- No. of pages:
- © Academic Press 1973
- 1st January 1973
- Academic Press
- eBook ISBN:
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