Drug Design

Drug Design

Medicinal Chemistry: A Series of Monographs, Vol. 4

1st Edition - January 1, 1973

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  • Editor: E. J. Ariëns
  • eBook ISBN: 9781483216065

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Drug Design, Volume IV covers the pharmaceutical phase of drug action, with emphasis on those aspects that are of importance in the design of optimally effective drug products. The book discusses biopharmaceutics as a basis for the design of drug products; the types and pharmacokinetics of peroral prolonged action dosage forms and parenteral prolonged action forms; and the design of topical drug products. The text also describes physical-chemical parameters which affect the bioavailability of topical drug products; the design of sunscreen preparations; as well as the clinical application of litholytic agents, which are preventive and curative drugs for nephrolithiasis. The design of biologically active nucleosides and of insecticidal chlorohydrocarbon derivatives is also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    Chapter 1. Biopharmaceutics as a Basis for the Design of Drug Products

    I. Introduction

    II. Biopharmaceutics—The Science of Input

    III. Bioavailability

    IV. Selection of the Route of Administration

    V. Getting Drugs into Solution

    VI. Gastrointestinal Membrane Transport

    VII. Getting Drugs into the Small Intestine


    Chapter 2. Peroral Solid Dosage Forms with Prolonged Action

    I. Introduction

    II. Types of Peroral Prolonged Action Dosage Forms

    III. Evaluation of Peroral Prolonged Action Dosage Forms

    IV. Pharmacokinetics

    V. Additives

    VI. Manufacturing Process


    Chapter 3. Parenteral Dosage Forms with Prolonged Action

    I. Introduction

    II. Types of Parenteral Prolonged Action Dosage Forms

    III. Evaluation of Parenteral Prolonged Action Dosage Forms


    Chapter 4. Design of Topical Drug Products: Pharmaceutics

    I. Skin

    II. Dermatological Bases

    III. Drugs

    IV. Testing


    Chapter 5. Design of Topical Drug Products: Biopharmaceutics

    I. Introduction

    II. Fundamentals of Drug Diffusion into Human Skin

    III. Optimizing Drug Availability from Topical Dosage Forms

    IV. Summary


    Chapter 6. The Design of Sunscreen Preparations

    I. Introduction

    II. Ultraviolet Radiation

    III. Human Reactions to Ultraviolet Radiation

    IV. Sunscreen Preparations

    V. Multiple Action Products

    VI. Evaluation of Sunscreen Preparations


    Chapter 7. Litholytic Agents: Preventive and Curative Drugs for Nephrolithiasis

    I. Introduction

    II. Factors Influencing Stone Formation

    III. Litholytic Agents

    IV. Possibilities for Dissolving the Four Different Types of Kidney Stones

    V. Clinical Application of the Litholytic Agents for the Dissolution of Kidney Stones

    VI. Summary


    Chapter 8. The Design of Biologically Active Nucleosides

    I. Introduction

    II. Functional Considerations

    III. Structural Considerations

    IV. Approaches toward Enhancing the Biological Activity of Nucleoside Analogs

    V. The Mode of Action of Nucleosides in Relation to Their Structure


    Chapter 9. The Design of Insecticidal Chlorohydrocarbon Derivatives

    I. Introduction

    II. Physical and Chemical Toxicants

    III. Aromatic Chlorohydrocarbon Insecticides: DDT Group

    IV. Chlorohydrocarbon Insecticides Derived from Reduced Cyclic Systems


    Author Index

    Subject Index

Product details

  • No. of pages: 506
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9781483216065

About the Editor

E. J. Ariëns

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