Drug Design
Medicinal Chemistry: A Series of Monographs, Vol. 4
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Drug Design, Volume IV covers the pharmaceutical phase of drug action, with emphasis on those aspects that are of importance in the design of optimally effective drug products. The book discusses biopharmaceutics as a basis for the design of drug products; the types and pharmacokinetics of peroral prolonged action dosage forms and parenteral prolonged action forms; and the design of topical drug products. The text also describes physical-chemical parameters which affect the bioavailability of topical drug products; the design of sunscreen preparations; as well as the clinical application of litholytic agents, which are preventive and curative drugs for nephrolithiasis. The design of biologically active nucleosides and of insecticidal chlorohydrocarbon derivatives is also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.
Table of Contents
List of Contributors
Preface
Contents of Other Volumes
Chapter 1. Biopharmaceutics as a Basis for the Design of Drug Products
I. Introduction
II. Biopharmaceutics—The Science of Input
III. Bioavailability
IV. Selection of the Route of Administration
V. Getting Drugs into Solution
VI. Gastrointestinal Membrane Transport
VII. Getting Drugs into the Small Intestine
References
Chapter 2. Peroral Solid Dosage Forms with Prolonged Action
I. Introduction
II. Types of Peroral Prolonged Action Dosage Forms
III. Evaluation of Peroral Prolonged Action Dosage Forms
IV. Pharmacokinetics
V. Additives
VI. Manufacturing Process
References
Chapter 3. Parenteral Dosage Forms with Prolonged Action
I. Introduction
II. Types of Parenteral Prolonged Action Dosage Forms
III. Evaluation of Parenteral Prolonged Action Dosage Forms
References
Chapter 4. Design of Topical Drug Products: Pharmaceutics
I. Skin
II. Dermatological Bases
III. Drugs
IV. Testing
References
Chapter 5. Design of Topical Drug Products: Biopharmaceutics
I. Introduction
II. Fundamentals of Drug Diffusion into Human Skin
III. Optimizing Drug Availability from Topical Dosage Forms
IV. Summary
References
Chapter 6. The Design of Sunscreen Preparations
I. Introduction
II. Ultraviolet Radiation
III. Human Reactions to Ultraviolet Radiation
IV. Sunscreen Preparations
V. Multiple Action Products
VI. Evaluation of Sunscreen Preparations
References
Chapter 7. Litholytic Agents: Preventive and Curative Drugs for Nephrolithiasis
I. Introduction
II. Factors Influencing Stone Formation
III. Litholytic Agents
IV. Possibilities for Dissolving the Four Different Types of Kidney Stones
V. Clinical Application of the Litholytic Agents for the Dissolution of Kidney Stones
VI. Summary
References
Chapter 8. The Design of Biologically Active Nucleosides
I. Introduction
II. Functional Considerations
III. Structural Considerations
IV. Approaches toward Enhancing the Biological Activity of Nucleoside Analogs
V. The Mode of Action of Nucleosides in Relation to Their Structure
References
Chapter 9. The Design of Insecticidal Chlorohydrocarbon Derivatives
I. Introduction
II. Physical and Chemical Toxicants
III. Aromatic Chlorohydrocarbon Insecticides: DDT Group
IV. Chlorohydrocarbon Insecticides Derived from Reduced Cyclic Systems
References
Author Index
Subject Index
Product details
- No. of pages: 506
- Language: English
- Copyright: © Academic Press 1973
- Published: January 1, 1973
- Imprint: Academic Press
- eBook ISBN: 9781483216065