1st Edition - June 23, 2014

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  • Editors: Marco Diana, Gaetano Di Chiara, Pierfranco Spano
  • Hardcover ISBN: 9780444634252
  • eBook ISBN: 9780444634276

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Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more.Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences.

Key Features

  • The most acclaimed and accomplished series in neuroscience
  • This volume looks at dopamine research in the light of the newest scholarly discoveries and insights


Neuroscientists, psychologists, neurologists

Table of Contents

  • Preface
    1: Thalamostriatal synapses—another substrate for dopamine action?
    1 The “Other” Striatal Input
    2 Thalamostriatal Targets
    3 Formation and Function of Thalamostriatal Synapses
    4 Impact of Thalamic Changes in Parkinson's Disease on the Motor System
    5 Spine Loss in Striatal Neurons After Dopamine Removal
    2: Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior
    1 Introduction
    2 Effects of Juvenile Methylphenidate + Fluoxetine Treatment on Gene Regulation in the Striatum
    3 Effects of Juvenile Methylphenidate + Fluoxetine Treatment on Molecular Signaling in the Midbrain and Behavior
    4 Discussion and Conclusions
    3: The role of learning-related dopamine signals in addiction vulnerability
    1 Background
    2 Model-free and Model-based Learning from Rewards
    3 Phasic Dopamine Signals Represent Model-free Prediction Errors
    4 Behavioral Characteristics of Model-free and Model-based Choices
    5 Individual Variability
    6 Addiction
    4: Dopaminergic function in relation to genes associated with risk for schizophrenia: translational mutant mouse models
    1 Introduction
    2 Mice Mutant for Dopamine-Related Genes
    3 Mice Mutant for DTNBP1 (dysbindin-1)
    4 Mice Mutant for NRG1/ErbB
    5 Gene × Environment and Gene × Gene Interactions
    6 Conclusions
    5: Dopamine D2 heteroreceptor complexes and their receptor–receptor interactions in ventral striatum: novel targets for antipsychotic drugs
    1 Introduction
    2 Allosteric Receptor–Receptor Interactions in Heteroreceptor Complexes
    3 On the Interface of Receptor Heteromers
    4 Adenosine A2AR–DA D2R Heteroreceptor Complexes
    5 DA D2–neurotensin NTS1 Heteroreceptor Complexes
    6 DA D2–5-HT2A Heteroreceptor Complexes
    7 5-HT2A–mGluR2 Heteroreceptor Complexes
    8 D2–oxytocinR Heteroreceptor Complexes
    9 Summary and Future Directions
    6: The multilingual nature of dopamine neurons
    1 The Particular Nature of Dopamine Neurons
    2 Discovery of Cotransmitters in DA Neurons
    3 Localization of Glutamatergic and Mixed Phenotype DA Neurons in the Brain
    4 Synaptic Connectivity and Plasticity of Glutamate Release by DA Neurons
    5 Developmental Role of Glutamate Release by DA Neurons
    6 Possible Contribution of VGLUT2 in DA Neurons to Vesicular Synergy
    7 Does Glutamate Corelease Mediate a Reward-Relevant Signal?
    7: Imaging dopamine neurotransmission in live human brain
    1 Molecular Imaging Techniques
    2 Basic Principles and Receptor Kinetic Models
    3 Single-Scan Dynamic Molecular Imaging Technique
    4 Use of Multiple Kinetic Models
    5 Study of Pathophysiology of Psychiatric Conditions
    6 Limitations and Future Directions
    7 Summary
    8: Dopamine receptor heteromeric complexes and their emerging functions
    1 Introduction
    2 The Dopamine D1 Receptor and D2 Receptor Heteromer
    3 The Dopamine D2 Receptor and Ghrelin Receptor Heteromer
    4 The Dopamine D2 Receptor and Adenosine Receptor Heteromer
    9: Alcohol: mechanisms along the mesolimbic dopamine system
    1 The Reward Systems in the Brain
    2 The Mesolimbic Dopamine System
    3 The Cholinergic–Dopaminergic Reward Link
    4 Addictive Behaviors
    5 The Role of Dopamine in Reward
    6 The Effects of the Dopamine Stabilizer (−)-OSU6162 on Alcohol Consumption in Rodents
    7 The Role of Different Reward Nodes for Alcohol Reward
    8 The Role of the Cholinergic–Dopaminergic Reward Link for Reward Induced by Addictive Drugs and Behavior
    9 Alcohol and Ligand-gated Ion Channels
    10 A Possible Role of Gut–brain Peptides for Drug Dependence
    11 Conclusions
    10: The role of dopamine in huntington's disease
    1 Introduction
    2 Striatal DA Innervation in the HD Postmortem Brain
    3 Neurochemistry
    4 DA Receptors
    5 DA in Genetic Animal Models of HD
    6 Synaptic Electrophysiology in HD Models
    7 DA and Synaptic Plasticity in HD
    8 DA and Excitotoxicity
    9 Mechanisms of DA Dysregulation
    10 DA Agonists and Antagonists as Treatments for HD
    11 Conclusions and Future Directions
    11: Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings
    1 Introduction
    2 Behavioral Effects of D3 Blockade in Animal Model of Drug Addiction
    3 Translating the D3 Hypothesis into Clinical Intervention
    4 Conclusion
    12: Effects of prenatal exposure to cocaine on brain structure and function
    1 Introduction
    2 Results
    3 Conclusions
    Volume in Series

Product details

  • No. of pages: 322
  • Language: English
  • Copyright: © Elsevier 2014
  • Published: June 23, 2014
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444634252
  • eBook ISBN: 9780444634276

About the Serial Volume Editors

Marco Diana

Affiliations and Expertise

University of Sassari, Italy

Gaetano Di Chiara

Affiliations and Expertise

University of Cagliari, Italy

Pierfranco Spano

Affiliations and Expertise

University of Brescia, Italy

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