DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics.

Key Features

@introbul:Special Features @bul:* Explains basic DNA Structure and function clearly and simply * Contains up-to-date coverage of cruciforms, Z-DNA, triplex DNA, and other DNA conformations * Discusses DNA-protein interactions, chromosomal organization, and biological implications of structure * Highlights key experiments and ideas within boxed sections * Illustrated with 150 diagrams and figures that convey structural and experimental concepts


Graduate and advanced undergraduate students and researchers in molecular biology, biochemistry, genetics, microbiology, biophysics, chemistry, cell biology, and biotechnology.

Table of Contents

Introduction to the Structure, Properties, and Reactions of DNA. DNA Bending. DNA Supercoiling. Cruciform Structures in DNA. Left-Handed Z-DNA. Triplex DNA. Miscellaneous Alternative Conformations of DNA. DNA-Protein Interactions. The Organization of DNA into Chromosomes. Author Index. Subject Index.


No. of pages:
© 1994
Academic Press
Print ISBN:
Electronic ISBN:

About the author

Richard Sinden

Affiliations and Expertise

Albert B. Alkek Institute of Biosciences and Technology, Texas A & M University, Houston, U.S.A.


@qu:"Well written, authoritative, organized and comprehensive coverage of a rapidly developing subject. It is a very impressive compilation and one which will be useful to a wide audience. The book introduces the reader to the complex mosaic of DNA architecture-the A, B, H, Z, supercoiled, and the cruciform structures of DNA. The interconversion of these structures, together with the interaction with sequence and/or structure specific proteins provides the basis for the delicate orchestration of the flow of the genetic message within the cell. In vitro, [as well as] in vivo experiments are presented. The DNA structural findings lead one into the specific relevance of these forms in the vital functional processes-replication, transcription, genetic recombination and DNA repair-which are at the cutting-edge of research in today's leading labs. All in all, an excellent job of bringing together a multitude of diverse topics on DNA and packaging them nicely in a comprehensive, readable volume." @source:--WILLIAM M. SCOVELL, Professor of Chemistry, Bowling Green State University @qu:"Richard Sinden, a leader in the study of nucleic acid structure, has crafted an outstanding treatment of DNA structure and function. I found this work, particularly the excellent illustrations, very useful for preparing lectures on aspects of DNA structure that are not a part of my daily work. After reviewing an early version, I insisted that Sinden keep me supplied with the latest revision so I would have easy access to the information. In summary, I consider Sinden's book required reading for any graduate student interested in how DNA works." @source:--KARL DRLICA, The Public Health Research Institute, New York, New York @qu:"Richard Sinden has consolidated the newer information necessary to understand DNA function beyond the notion that it simply encodes information by its line