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1. DNA repair by photolyases
Ibrahim Halil Kavakli, Nuri Ozturk and Seref Gul
2. TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair
Olga Kolesnikova, Laura Radu, and Arnaud Poterszman
3. Chromatin control in double strand break repair
Anastas Gospodinov and Iva Ugrinova
4. Controlling the balance between chromosome break repair pathways
Sonia Jimeno, Fernando Mejías-Navarro, Rosario Prados-Carvajal and Pablo Huertas
5. Targeting DNA repair in precision medicine
Reena Beggs and Eddy S. Yang
6. Replication stress: Driver and therapeutic target in genomically instable cancers
Pepijn M. Schoonen, Sergi Guerrero Llobet and Marcel A.T.M. van Vugt
7. Claspin: From replication stress and DNA damage responses to cancer therapy
Diana Azenha, Maria Celeste Lopes and Teresa C. Martins
8. cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy
Nathaniel C. Holcomb, Robert-Marlo Bautista, Stuart G. Jarrett, Madeline Krentz Gober, Katharine M. Carter and John A. D’Orazio
9. Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling
Shibani Mukherjee, Salim Abdisalaam, Souparno Bhattacharya, Kalayarasan Srinivasan, Debapriya Sinha and Aroumougame Asaithamby
10. Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach
D. Thirumal Kumar, B. Susmita, E. Judith, J. Priyadharshini Christy, C. George Priya Doss and Hatem Zayed
11. A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase
Thirumal Kumar D., Enid Mendonca, J. Priyadharshini Christy, C. George Priya Doss and Hatem Zayed
DNA Repair, Volume 115, the latest release in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair, their involvement in maintaining chromatin repair, the balance between chromosome breaks repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Specific chapters cover the Structure and function of the multi-subunit TFIIH with insights into nucleotide excision repair, Chromatin repair: how DNA packaging controls double-strand break repair, Controlling the balance between chromosome breaks repair pathways, The targeting of DNA repair pathways in the era of precision oncology, and much more.
- Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases
- Presents data that is targeted to a very wide audience of specialists, researchers and students
- Contains timely chapters written by well-renowned authorities in their field
- Provides targeted information that is well supported by a number of high-quality illustrations, figures and tables
Protein chemists, biochemists, molecular biologists, cell biologists, immunologists, neuroscientists, structural biologists, medical doctors, pharmacologists, computational biochemists and other researchers working in this field. Articles published here would also be of a great benefit to medical, biology and pharmacology students specializing in this field
- No. of pages:
- © Academic Press 2019
- 20th February 2019
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on design of antibody-based oral treatment of pathological conditions of the gastrointestinal tract.
Swansea University, UK
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