DNA and Chromatin Damage Caused by Radiation

DNA and Chromatin Damage Caused by Radiation

1st Edition - January 1, 1993

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  • Editors: John T. Lett, Warren K. Sinclair
  • eBook ISBN: 9781483282275

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Advances in Radiation Biology, Volume 17: DNA and Chromatin Damage Caused by Radiation outlines the different biological reactions to radiation. This book discusses the linear energy transfer and energy loss; DNA breaks and track structure; DNA radicals from water radicals; and radiation-induced strand breaks in isolated DNA. The radiation damage to DNA and its nearby environment; thiol radioprotectors and mechanism of action; radiolysis of water and track reactions; and computer simulation of higher order structure of DNA are also elaborated. This publication likewise covers the concept of chromatin structure; DNA supercoiling studied by sedimentation; measurement of radiation-induced DNA breakage; and analysis of damage in interphase cells. This volume is a useful reference to biologists and students concerned with DNA and chromatin damage caused by radiation.

Table of Contents

  • Linear Energy Transfer and Track Structure

    I. Introduction

    II. Linear Energy Transfer and Energy Loss

    III. δ-Electron Emission

    IV. Condensed Phase Effects—Track Core

    V. Electron Transport and the Track Halo

    VI. DNA Breaks and Track Structure

    VII. Summary


    Primary Free Radical Processes in DNA

    I. Introduction

    II. DNA Radicals from Water Radicals—Recent Advances

    III. One-Electron Oxidized Species of DNA in an Aqueous Environment

    IV. Dynamics of Radiation-Induced Changes in Solid DNA

    V. Radiation-Induced Strand Breaks in Isolated DNA

    VI. Forward Look


    The Chemical Consequences of Radiation Damage to DNA

    I. Introduction

    II. Radiation Damage to DNA and Its Nearby Environment: Direct and Quasi-direct Effects

    III. The Indirect Effect

    IV. The Confluence of Chemical Events for the Direct, Quasidirect, and Indirect Effects

    V. Thiol Radioprotectors and Mechanism of Action

    VI. Conclusions and Directions for Future Efforts


    Computer Simulation of Initial Events in the Biochemical Mechanisms of DNA Damage

    I. Introduction

    II. Energy Deposition Events and Creation of Tracks by Charged Particles

    III. Radiolysis of Water and Track Reactions

    IV. Computer Simulation of the Biochemical Stage: The Formation of Strand Breaks

    V. Results of Yields on Strand Breaks

    VI. Computer Simulation of Higher Order Structure of DNA

    VII. Concluding Remarks and Future Directions


    DNA Loop Structure and Radiation Response

    I. Introduction

    II. The Concept of Chromatin Structure

    III. DNA Supercoiling Studied by Sedimentation

    IV. Alternative Methods

    V. DNA Loop Structure and Growth State

    VI. DNA Loop Structure, Anchoring, and Radiosensitivity

    VII. Cell Cycle Effects

    VIII. Conclusions


    Radiation-Induced Damage in Chromosomal DNA Molecules: Deduction of Chromosomal DNA Organization from the Hydrodynamic Data Used to Measure DNA Double-Strand Breaks and from Stereo Electron Microscopic Observations

    I. Introduction

    II. Methods for the Measurement of DNA Breakage

    III. DNA Size, Shape, and Number Concentration Measurement

    IV. Problems Unique to the Measurement of Large DNA Molecules

    V. Measurement of Radiation-Induced DNA Breakage

    VI. Size and Shape Determination of Mammalian Cell Chromosomal DNA Molecules

    VII. Structure of the Mammalian Chromosome

    VIII. Summary


    Ionizing Radiation Damage and Its Early Development in Chromosomes

    I. Introduction

    II. Chromosomal Aberrations at Mitosis

    III. Analysis of Damage in Interphase Cells

    IV. What Are PCC Breaks?

    V. The Nature of Critical Cellular Structures

    VI. Conclusions



Product details

  • No. of pages: 516
  • Language: English
  • Copyright: © Academic Press 1993
  • Published: January 1, 1993
  • Imprint: Academic Press
  • eBook ISBN: 9781483282275

About the Editors

John T. Lett

Warren K. Sinclair

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