DNA and Chromatin Damage Caused by Radiation - 1st Edition - ISBN: 9780120354177, 9781483282275

DNA and Chromatin Damage Caused by Radiation

1st Edition

Editors: John T. Lett Warren K. Sinclair
eBook ISBN: 9781483282275
Imprint: Academic Press
Published Date: 22nd October 1993
Page Count: 516
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Advances in Radiation Biology, Volume 17: DNA and Chromatin Damage Caused by Radiation outlines the different biological reactions to radiation. This book discusses the linear energy transfer and energy loss; DNA breaks and track structure; DNA radicals from water radicals; and radiation-induced strand breaks in isolated DNA. The radiation damage to DNA and its nearby environment; thiol radioprotectors and mechanism of action; radiolysis of water and track reactions; and computer simulation of higher order structure of DNA are also elaborated. This publication likewise covers the concept of chromatin structure; DNA supercoiling studied by sedimentation; measurement of radiation-induced DNA breakage; and analysis of damage in interphase cells. This volume is a useful reference to biologists and students concerned with DNA and chromatin damage caused by radiation.

Table of Contents

Linear Energy Transfer and Track Structure

I. Introduction

II. Linear Energy Transfer and Energy Loss

III. δ-Electron Emission

IV. Condensed Phase Effects—Track Core

V. Electron Transport and the Track Halo

VI. DNA Breaks and Track Structure

VII. Summary


Primary Free Radical Processes in DNA

I. Introduction

II. DNA Radicals from Water Radicals—Recent Advances

III. One-Electron Oxidized Species of DNA in an Aqueous Environment

IV. Dynamics of Radiation-Induced Changes in Solid DNA

V. Radiation-Induced Strand Breaks in Isolated DNA

VI. Forward Look


The Chemical Consequences of Radiation Damage to DNA

I. Introduction

II. Radiation Damage to DNA and Its Nearby Environment: Direct and Quasi-direct Effects

III. The Indirect Effect

IV. The Confluence of Chemical Events for the Direct, Quasidirect, and Indirect Effects

V. Thiol Radioprotectors and Mechanism of Action

VI. Conclusions and Directions for Future Efforts


Computer Simulation of Initial Events in the Biochemical Mechanisms of DNA Damage

I. Introduction

II. Energy Deposition Events and Creation of Tracks by Charged Particles

III. Radiolysis of Water and Track Reactions

IV. Computer Simulation of the Biochemical Stage: The Formation of Strand Breaks

V. Results of Yields on Strand Breaks

VI. Computer Simulation of Higher Order Structure of DNA

VII. Concluding Remarks and Future Directions


DNA Loop Structure and Radiation Response

I. Introduction

II. The Concept of Chromatin Structure

III. DNA Supercoiling Studied by Sedimentation

IV. Alternative Methods

V. DNA Loop Structure and Growth State

VI. DNA Loop Structure, Anchoring, and Radiosensitivity

VII. Cell Cycle Effects

VIII. Conclusions


Radiation-Induced Damage in Chromosomal DNA Molecules: Deduction of Chromosomal DNA Organization from the Hydrodynamic Data Used to Measure DNA Double-Strand Breaks and from Stereo Electron Microscopic Observations

I. Introduction

II. Methods for the Measurement of DNA Breakage

III. DNA Size, Shape, and Number Concentration Measurement

IV. Problems Unique to the Measurement of Large DNA Molecules

V. Measurement of Radiation-Induced DNA Breakage

VI. Size and Shape Determination of Mammalian Cell Chromosomal DNA Molecules

VII. Structure of the Mammalian Chromosome

VIII. Summary


Ionizing Radiation Damage and Its Early Development in Chromosomes

I. Introduction

II. Chromosomal Aberrations at Mitosis

III. Analysis of Damage in Interphase Cells

IV. What Are PCC Breaks?

V. The Nature of Critical Cellular Structures

VI. Conclusions




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© Academic Press 1993
Academic Press
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About the Editor

John T. Lett

Warren K. Sinclair

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