Disorders of Emotion in Neurologic Disease

1st Edition, Volume 183 - August 11, 2021
Editors: Kenneth M. Heilman, Stephen E Nadeau
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 2 9 0 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 2 8 9 - 8

Disorders of Emotion in Neurologic Disease, Volume 183 in the Handbook of Clinical Neurology Series, informs clinicians on which neurologic diseases are likely to have a secondary… Read more

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Disorders of Emotion in Neurologic Disease, Volume 183 in the Handbook of Clinical Neurology Series, informs clinicians on which neurologic diseases are likely to have a secondary effect on emotion, what to look for in diagnosis, and best practices for treatment. The book begins with an understanding of the neurological basis for emotions in order to better understand what goes awry in neurological disease. It then discusses specific neurologic diseases and disorders affecting emotion.

Cover image
Title page
Table of Contents
Copyright
Handbook of Clinical Neurology 3rd Series
Foreword
Preface
Contributors
Chapter 1: The neuroscience of emotional disorders
Abstract
Introduction
The Orbitofrontal Cortex
The Amygdala
The Cingulate Cortex
Emotion and Autonomic Responses
The “Limbic System” and Emotion
Emotional Disorders: Depression
Acknowledgment
Chapter 2: Unconscious processing of emotions and the right hemisphere
Abstract
Introduction
Emotions and Emotional Processing
Hemispheric Asymmetries in Emotional Functions
Right Hemispheric and Right Amygdala Dominance in the Unconscious Processing of Emotional Information
“Removed” and “Nonremoved” Forms of Unconscious
Conclusions
Chapter 3: Alexithymia
Abstract
Introduction
Alexithymia as a Transdiagnostic Clinical Symptom
Neurobiology of Emotional Awareness
Challenges and Opportunities
Conclusion
Chapter 4: Disorders of vocal emotional expression and comprehension: The aprosodias
Abstract
Historical Background
Neurology of Prosody and Associated Acoustical Features
Neurology of Affective Prosody and the Aprosodias
Acoustical Underpinnings of Affective Prosody in Tone and Nontone Languages
Right Hemisphere Dominance for Modulating Affective Prosody
The Aprosodias: Functional-Anatomic Correlates after RBD
Functional Imaging: An Unreliable Methodology for Localization of Language Functions
Affective-Prosodic Deficits Associated with Neuropsychiatric Conditions, Neurodegenerative Disorders, and Aging
Management of Patients with Disorders of Vocal Emotional Communication
Conclusion
Chapter 5: Disorders of facial emotional expression and comprehension
Abstract
Introduction
Comprehension of Facial Emotional Expressions
Facial Expression of Emotion
Summary
Chapter 6: Emotional disorders and the cerebellum: Neurobiological substrates, neuropsychiatry, and therapeutic implications
Abstract
Introduction
Cerebellar Gross Anatomy
Cerebellar Histology
Historical Background to Cerebellar Cognition
Sensorimotor Integration—A Developmental Hypothesis Related to Cerebellum
Demonstration of a Cerebellar Influence on Modulation of Emotion
Cerebellum Is an Essential Node in the Distributed Neural Circuits Subserving Cognition and Emotion
Cerebellar Connections with the Limbic System
Topographic Arrangement of Sensorimotor and Associative Connections
Functional Topography in the Human Cerebellum
The Cerebellar Cognitive Affective Syndrome—First Identification in Adults
Replication of the CCAS
CCAS scale
The CCAS in children
Cerebellar Mutism and CCAS Following Cerebellar Tumor Resection in Children
Developmental CCAS
The hereditary ataxias
Neuropsychiatry of the Cerebellum: the Affective Component of the CCAS
Social Cognition and the Cerebellum
Language and Metalinguistic Impairments in Patients with Cerebellar Dysfunction
The Dysmetria of Thought Theory: A Unifying Hypothesis
Empirical Tests of the Dysmetria of Thought Theory
Future Directions
Implications for Therapy
Conclusions
Chapter 7: Hemispheric stroke: Mood disorders
Abstract
Introduction
Hemispheric Asymmetry of Emotion
Mood Changes Following a Left-Hemisphere Stroke
Mood Changes Following a Right-Hemisphere Stroke
Clinical and Cognitive Correlates of Mood Changes Following Stroke
Possible Interventions and Treatment
Conclusion
Chapter 8: Emotion and mood disorders associated with epilepsy
Abstract
Introduction
Ictal and Postictal Emotions
Interictal Mood Disorders
Alterations in Emotional Processing
Treatment of Emotional and Mood Disorders
Summary
Chapter 9: Mood and emotional disorders associated with parkinsonism, Huntington disease, and other movement disorders
Abstract
Parkinson's Disease
Atypical Parkinsonian Disorders
Frontotemporal Dementia with Parkinsonism
Huntington's Disease
Other Movement Disorders
Conclusions
Chapter 10: The emotional disorders associated with multiple sclerosis
Abstract
Introduction
Depression in MS
Bipolar Disorder and Mania
Anxiety
Emotional Blunting (Apathy)
Pseudobulbar Affect
Conclusion
Chapter 11: Paraneoplastic and autoimmune encephalitis: Alterations of mood and emotion
Abstract
Introduction
Selected Autoimmune Encephalitides Associated with Synaptic Receptors and Neuronal Cell Surface Proteins
Selected Autoimmune Encephalitides Associated with Antibodies Targeting Intracellular Antigens
Diagnosis of AE
General Overview of Symptoms Associated with Autoimmune Encephalitis
Suggestions for the Early Detection of Anti-NMDA Receptor Autoimmune Encephalitis
Treatment of Neurological and Neuropsychiatric Symptoms Associated with Autoimmune Encephalitis
Conclusion
Chapter 12: The effect of severe traumatic brain injury on social cognition, emotion regulation, and mood
Abstract
The Nature of Traumatic Brain Injury
Premorbid Personality
Social Cognition
Disorders of Behavioral and Emotional Regulation
Mild TBI
Conclusion
Chapter 13: Degenerative dementias: Alterations of emotions and mood disorders
Abstract
Introduction
Alzheimer's Disease
Frontotemporal Dementia
Conclusions
Chapter 14: Treatment of disorders of emotional comprehension, expression, and emotional semantics
Abstract
Introduction
Treatment of Emotional Disorders: General Principles
Disorders of Emotional Expression and Comprehension
Emotional Semantics
Conclusion
Chapter 15: Neural mechanisms of emotions, alexithymia, and depression
Abstract
Introduction
The Structure of Population Encoding Networks
Functional Implications of Population Encoding Networks
A Global Model of Emotional Function
Emotional Semantics
Acquisition of Knowledge and the James–Lange Theory
Connectivity of Orbitofrontal Cortex and Dorsolateral Prefrontal Cortex
The Roles of the Amygdala and Limbic Striatum
The Respective Roles of the Right and Left Hemispheres
Lesion Effects
Alexithymia
Depression
Conclusion
Index

Kenneth M. Heilman

Kenneth M. Heilman received his M.D. degree from the University of Virginia in 1963, trained in Internal Medicine at Cornell-Bellevue Hospital, served in the US Air Force as Chief of Medicine at NATO Hospital, Izmir, Turkey. He took a Neurology residency and fellowship at the Harvard Neurological Unit of Boston City (1967-1970), and then joined the faculty at the University of Florida. He was the James E. Rooks Jr. Distinguished Professor and currently is a Distinguished Professor Emeritus. Between 1996 and 2009, he was Chief of the Neurology Service at the Gainesville VA. He has helped to trained more than 70 post-doctoral fellows. His research has been supported by the NIH and/or the VA for more than 40 years. He is the author/editor of 18 books, and more than 650 journal publications. He is a past President of the International Neuropsychology Society (INS) and the Society for Cognitive and Behavioral Neurology and received a Distinguished Career Awards from both. He is an Honorary Member of the American Neurological Association a Fellow in the American Academy of Neurology (AAN) and received the Wartenberg Keynote Lecturer Award from the AAN.

Affiliations and expertise

Geriatric Research, Education, Malcom Randall VA Medical Center, Gainesville, FL, USA

Stephen E Nadeau

Stephen E. Nadeau is an Associate Chief of Staff for Research, Malcom Randall VA Medical Center, Gainesville, FL; Professor of Neurology, University of Florida College of Medicine. Fellow, American Academy of Neurology and member, International Neuropsychological Association. Past Associate Editor, Journal of the International Neuropsychological Society. Past editing experience: Aphasia and Language: Theory to Practice (with Leslie J. Gonzalez Rothi and Bruce Crosson; NY: Guilford, 2000); Cognitive Changes and the Aging Brain (with Kenneth M. Heilman; Cambridge: Cambridge University Press, in proof).

Affiliations and expertise

Associate Chief of Staff for Research, Malcom Randall VA Medical Center, Gainesville, Florida, USA Professor of Neurology, University of Florida College of Medicine, Florida, USA