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Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases - 1st Edition - ISBN: 9780128157237, 9780128157244

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

1st Edition

Editor: Goutam Brahmachari
Paperback ISBN: 9780128157237
eBook ISBN: 9780128157244
Imprint: Elsevier
Published Date: 12th April 2019
Page Count: 458
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Table of Contents

1. Therapeutics from Natural Products against Neglected Tropical Diseases: An Overview
2. Marine Natural Products as Strategic Prototypes in the Development of a New Generation of Antimalarial Agents
3. Sesquiterpene Lactones: A Versatile Class of Structurally Diverse Natural Products and Their Semisynthetic Analogs as Potential Antimalarials
4. Natural and Synthetic Quinoline Molecules against Tropical Parasitic Pathologies: An Analysis of Activity and Structural Evolution for Developing New Quinoline-based Antiprotozoal Agents
5. Promising Trypanocidal Heterocyclic Compounds of Natural Origin and Their Synthetic Analogs
6. Oxidative Stress in Schistosomiasis, Echinococcosis, and Trypanosomiasis: A Therapeutic Approach
7. Plant Derived Compounds against Protozoan Neglected Diseases: Towards Sustainable Drug Development
8. Leishmaniasis Control: Limitations of Current Drugs and Prospects of Natural Products
9. Natural Antileprotic Agents: A Boon for the Management of Leprosy
10. Aloe Vera: A Promising Hope Against Buruli Ulcer
11. Plant and Marine Products: A Promising Hope in Search of Therapeutics Against Dengue
12. Total Synthetic Approaches for Lucidone - A Promising Natural Lead Candidate Against Dengue Infection


Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more.

In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases.

Key Features

  • Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery
  • Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases
  • Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases


Natural products chemists, Synthetic chemists, Phytochemists, Medicinal chemists, Neglected disease researchers, Combinatorial chemists, Pharmaceutical Scientists, Plant Scientists, Manufacturers of natural products, Researchers in both academia and industry


No. of pages:
© Elsevier 2019
12th April 2019
Paperback ISBN:
eBook ISBN:

Ratings and Reviews

About the Editor

Goutam Brahmachari

Goutam Brahmachari

Goutam Brahmachari is a professor of organic chemistry at Visva-Bharati, India, and teaches courses in organic chemistry, natural products chemistry, synthetic organic chemistry, and physical methods in organic chemistry. In addition to over 20 years of teaching and research experience, he is a Fellow of the Royal Society of Chemistry, a Who’s Who in the World Listee, and a recipient of Academic Brilliance Award (2015) for Excellence in Research and the Dr. Kalam Best Teaching Faculty Award (2017). Prof. Brahmachari serves as journal referee, editor-in-chief, associate editor, guest editor, and Editorial Advisory Board Member for several international journals, book publishers, and research funding agencies. He currently has 200 publications in the fields of organic and medicinal chemistry, including 22 books and over 40 book chapters, published by internationally reputed publishers.

Affiliations and Expertise

Full Professor of Organic Chemistry, Department of Chemistry, Visva-Bharati (a Central University), Santiniketan, West Bengal, India