Dictyostelium Discoideum - 1st Edition - ISBN: 9780124561502, 9780323159807

Dictyostelium Discoideum

1st Edition

A Developmental System

Authors: William Loomis
eBook ISBN: 9780323159807
Imprint: Academic Press
Published Date: 1st January 1975
Page Count: 224
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Description

Dictyostelium Discoideum: A Developmental System presents D. discoideum as a model eukaryotic system to study a variety of developmental problems. The book describes the life cycle of the organism D. discoideum which exists in nature as a soil amoeba in forest detritus. The nuclei of D. discoideum contain DNA, RNA, and proteins which have properties similar to those of histones present in calf thymus nuclei. The unique sequences of the genome of the organism code for the gene products synthesize during its growth and development. One approach in genetic analyses to understanding the developmental processes of the organism is to isolate a large number of morphological mutants. The isolation process will indicate the number of variations that are open to the developing system, and will point to causal connections between stages. The text also explains that the number of cells which differentiate into stalk cells is the result of timing and mechanics of the process of culmination. Ashworth (1971) suggests that cells in pseudoplasmodia of D. discoideum adjust their positions in relation to the chemical structure of the sheath itself. A model shows how cells communicate their response to the sheath in an axial fashion. The book can prove beneficial for biochemists, micro-biologists, cellular researchers, and investigators involved in the study of cellular biology.

Table of Contents


Preface

Chapter 1 The Life Cycle

An Overview

Related Species

Chapter 2 Amoeboid Stage

Growth Conditions

Amoeboid Movement in D. Discoideum

Feeding

Ultrastructure

Chapter 3 The Genome

Karyotype

Nuclear Composition

Mitochondrial DNA

Repetitive Sequences

Unique Sequences

Chapter 4 Genetics of Dictyostelium

Genetic Approaches

Mutational Genetics

Parasexuality

Sexuality

Stock Maintenance

Chapter 5 Aggregation Stage

Chemotaxis

Periodic Movement

Cohesion of Developing Cells

Chapter 6 Pseudoplasmodial Stage

Integration

Polarity of Migration

Phototaxis

Thermotaxis

Cell Sorting in Pseudoplasmodia

Chapter 7 Culmination Stage

Stalk Formation

Spore Formation

Avoidance Reaction

Germination Inhibitor

Germination

Mutational Analysis of Culmination

Chapter 8 Macromolecular Aspects of Development

Decrease in Dry Weight and Oxygen Consumption

Protein Content

RNA Content

Polysaccharide Content

DNA Content

Axenically Grown Cells

RNA Metabolism

Structure of Nuclear and Cytoplasmic RNA

Transcriptional Changes

Chapter 9 Enzymatic Aspects of Development

Enzymes of the Growth Phase

Enzymes of Growth and Development

Enzymes of Development

Marker Enzymes of Development

Enzyme Synthesis

Enzyme Degradation

Stage-Specific Enzymes

Mutational Analysis of Stage-Specific Enzymes

Chapter 10 Changes in Metabolites during Development

Cells Grown on Bacteria

Axenically Grown Cells

Chapter 11 The Relation of Biochemical Differentiations to Morphogenesis

Aggregation

Pseudoplasmodium Formation

Culmination

Glycogen Metabolism

Substrate Concentrations

Metabolic Modeling

Genetic Analysis

Chapter 12 Modifications of Development

Submerged Cultures

Cell Density

Overhead Light

Dissociation

Mechanical Barriers

Effect of Nutrients

Phenocopies of Aggregateless Mutants

Phenocopies of Fruitless Mutants

Phenocopies of Culmination Mutants

Growth Conditions

Genetic Modifications

Synergy

Chapter 13 Tissue Proportioning

Size Invariance

Mechanical Analysis

Differentiations of Prespore and Prestalk Cells

Cell Sorting and Determination

Regulation of Tissue Proportions

Positional Information

Cell Contact Model

Diffusional Barrier Model

Structural Model

Bibliography

Subject Index

Details

No. of pages:
224
Language:
English
Copyright:
© Academic Press 1975
Published:
Imprint:
Academic Press
eBook ISBN:
9780323159807

About the Author

William Loomis