Diagnostic Pathology: Genitourinary

Diagnostic Pathology: Genitourinary

3rd Edition - June 13, 2022

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  • Authors: Mahul B. Amin, Satish K. Tickoo
  • Hardcover ISBN: 9780323763325

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Offering complete, practical guidance on the evaluation of the surgical pathology specimen, the Manual of Surgical Pathology concentrates decades of experience from the faculty and staff of one of the busiest and most respected pathology departments in the world. From a specimen’s arrival in the department to preparation of the final report, you’ll find step-by-step instructions on specimen processing, tissue handling, gross dissection technique, histological examination, application of special stains, development of a differential diagnosis, and more. The fully revised 4th Edition is an invaluable reference for practicing pathologists, residents, and pathology assistants as a practical, everyday resource for learning and applying optimal specimen evaluation as well as an excellent guide for board review.

Table of Contents

  • Kidney Tumors and Tumor-Like Conditions

    Introduction and Overview

    Introduction to Renal Cell Tumors

    Classification of Kidney Tumors and Tumor-Like Lesions

    Familial Cancer Syndromes

    von Hippel-Lindau Syndrome

    Birt-Hogg-Dubé Syndrome

    Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome

    Tuberous Sclerosis Complex

    Succinate Dehydrogenase Complex Deficiency Syndrome

    Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer Syndromes

    Nonneoplastic Lesions

    Renal Tuberculosis, Xanthogranulomatous Pyelonephritis, Renal Malakoplakia

    Renal Cell Tumors, Benign

    Papillary Adenoma

    Renal Oncocytoma

    Renal Cell Carcinoma

    Clear Cell Renal Cell Carcinoma

    Multilocular Cystic Clear Cell Renal Cell Neoplasm of Low Malignant Potential

    Clear Cell Renal Cancers With Fibromyomatous Stroma, Including *ELOC*/*TCEB1*-Mutated Renal Cell Carcinoma

    Clear Cell Papillary Renal Cell Carcinoma

    Papillary Renal Cell Carcinoma

    Chromophobe Renal Cell Carcinoma

    Collecting Duct Carcinoma

    Renal Medullary Carcinoma and Unclassified Carcinomas With Medullary Phenotype

    MiTF/TFE Family Translocation-Associated Carcinoma

    Mucinous Tubular and Spindle Cell Carcinoma

    Tubulocystic Carcinoma

    Thyroid-Like Follicular Carcinoma of Kidney

    Acquired Cystic Disease-Associated Renal Cell Carcinoma

    Fumarate Hydratase-Deficient Renal Cell Carcinoma

    *ALK* Rearrangement-Associated Renal Cell Carcinoma

    Eosinophilic Solid and Cystic Renal Cell Carcinoma

    Eosinophilic Tumors With Somatic *TSC*/*MTOR* Mutations

    Subsequent 2nd Tumors

    Renal Cell Carcinoma, Unclassified

    Metanephric Tumors

    Metanephric Adenoma

    Metanephric Tumors Other Than Metanephric Adenoma

    Nephroblastic Tumors

    Nephrogenic Rests

    Nephroblastoma (Wilms Tumor)

    Cystic Partially Differentiated Nephroblastoma

    Mesenchymal Tumors


    Epithelioid Angiomyolipoma

    Congenital Mesoblastic Nephroma

    Clear Cell Sarcoma of Kidney

    Malignant Rhabdoid Tumor

    Mixed Mesenchymal and Epithelial Tumors

    Mixed Epithelial and Stromal Tumor (MEST) Family Tumors and Pediatric Cystic Nephroma

    Synovial Sarcoma

    Neuroendocrine Tumors

    Well-Differentiated Neuroendocrine Tumor (Carcinoid) and High-Grade Neuroendocrine Carcinoma

    Primitive Neuroectodermal Tumor

    Hematopoietic Tumors

    Hematopoietic Tumors

    Metastatic and Other Tumors

    Juxtaglomerular Cell Tumor (Reninoma)

    Renomedullary Interstitial Cell Tumor

    Other Rare Tumors

    Metastatic Tumors

    Immunohistochemical Profiles for Tumors Involving Kidney

    Immunohistochemistry, Kidney

    Urinary Tract

    Introduction and Overview

    Classification of Bladder Tumors and Tumor-Like Lesions

    Microscopic Anatomy

    Microscopic Anatomy of Urinary Bladder

    Microscopic Anatomy of Urethra

    Microscopic Anatomy of Ureter

    Microscopic Anatomy of Renal Pelvis

    Nonneoplastic Lesions of Urinary Tract

    Overview of Cystitis

    Polypoid Cystitis



    von Brunn Nests

    Nephrogenic Adenoma (Metaplasia)

    Fibroepithelial Polyp

    Prostatic-Type Polyp (Ectopic Prostate)


    Müllerian Lesions

    Pseudocarcinomatous Hyperplasia


    Urothelial Neoplasms, General

    Overview of Urinary Bladder Neoplasms

    Flat Urothelial Lesions

    Urothelial Carcinoma In Situ

    Flat Urothelial Lesions Other Than Carcinoma In Situ

    Urothelial Neoplasms, Noninvasive

    Urothelial Proliferation of Unknown Malignant Potential

    Urothelial Papilloma

    Papillary Urothelial Neoplasm of Low Malignant Potential

    Low-Grade Papillary Urothelial Carcinoma

    High-Grade Papillary Urothelial Carcinoma

    Inverted Urothelial Neoplasia

    Urothelial Neoplasms, Invasive

    Invasive Urothelial Carcinoma

    Urothelial Carcinoma, Variants and Divergent Differentiation

    Glandular Lesions

    Cystitis Cystica et Glandularis

    Villous Adenoma

    Invasive Adenocarcinoma

    Clear Cell Adenocarcinoma

    Squamous Lesions

    Squamous Proliferations Other Than Carcinoma

    Invasive Squamous Cell Carcinoma

    Mesenchymal Lesions

    Myofibroblastic Proliferations

    Smooth Muscle Tumors


    Other Mesenchymal Tumors

    Other Tumors of Urinary Bladder


    Metastatic/Secondary Involvement of Bladder

    Diverticula of Urinary Tract


    Diverticular-Associated Neoplasia


    Inflammatory Lesions of Urethra

    Carcinoma of Urethra

    Other Tumors and Tumor-Like Lesions of Urethra


    Urothelial Carcinoma of Ureter

    Other Tumors and Tumor-Like Lesions of Ureter

    Renal Pelvis

    Urothelial Carcinoma of Renal Pelvis

    Other Tumors and Tumor-Like Lesions of Renal Pelvis


    Urachal Remnants

    Tumors of Urachus

    Immunohistochemical Profiles for Tumors Involving Urinary Bladder

    Immunohistochemistry, Urinary Tract

    Prostate Gland and Seminal Vesicle

    Introduction and Overview

    Classification of Prostate Tumors and Tumor-Like Lesions

    General Concepts, Prostate

    Microanatomy and Zonal Variations

    Imaging Considerations for Pathologists

    Nonneoplastic Lesions


    Prostate Hyperplasia


    Atrophy and Its Variants

    Hyperplasia of Mesonephric Remnants

    Verumontanum Mucosal Gland Hyperplasia

    Nephrogenic Adenoma (Metaplasia) of Prostatic Urethra

    Putative Premalignant Lesions and Lesions Falling Short of Malignant Diagnosis

    Prostatic Intraepithelial Neoplasia

    Prostate Neoplasms

    General Concepts, Prostate Carcinoma

    Acinar Adenocarcinoma

    Acinar Adenocarcinoma Variants

    Atypical Small Acinar Proliferations

    Intraductal Proliferations and Ductal Carcinoma

    Ductal Adenocarcinoma

    Urothelial Carcinoma Involving Prostate Gland

    Prostate Carcinoma With Neuroendocrine Differentiation

    Basal Cell Carcinoma

    Sarcomatoid Carcinoma of Prostate

    Carcinomas With Squamous Differentiation

    Cystic Epithelial Tumors of Prostate

    Stromal Tumors

    Mesenchymal Tumors of Prostate

    Melanocytic Lesions of Prostate

    Hematopoietic Neoplasms of Prostate

    Secondary Tumors of Prostate

    Tumors of Seminal Vesicle

    Mixed Epithelial and Stromal Tumor

    Seminal Vesicle Adenocarcinoma

    Immunohistochemical Profiles for Tumors and Tumor-Like Lesions Involving Prostate Gland

    Immunohistochemistry, Prostate

    Testis and Paratesticular Structures

    Introduction and Overview

    Classification of Testis and Paratestis Tumors and Tumor-Like Lesions

    Nonneoplastic Lesions


    Sertoli Cell-Only Syndrome

    Nontuberculous Infections

    Nonspecific Granulomatous Orchitis

    Tuberculous Epididymo-Orchitis

    Germ Cell Tumors

    General Concepts, Germ Cell Tumors

    Germ Cell Tumors Related to Germ Cell Neoplasia In Situ

    Germ Cell Neoplasia In Situ


    Intratubular Seminoma

    Intratubular Embryonal Carcinoma

    Embryonal Carcinoma

    Yolk Sac Tumor

    Choriocarcinoma and Other Trophoblastic Tumors

    Postpubertal-Type Teratoma

    Mixed Germ Cell Tumors

    Somatic-Type Malignancy in Germ Cell Tumor

    Burnt-Out (Regressed) Germ Cell Tumor

    Germ Cell Tumors Unrelated to Germ Cell Neoplasia In Situ

    Spermatocytic Tumor

    Pediatric Germ Cell Tumor, General Concepts

    Prepubertal-Type Teratoma

    Yolk Sac Tumor, Prepubertal Type

    Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type

    Well-Differentiated Neuroendocrine Tumor (Monodermal Teratoma)

    Sex Cord-/Gonadal Stromal Tumors

    General Concepts, Sex Cord-/Gonadal Stromal Tumors

    Leydig Cell Tumors

    Sertoli Cell Tumors

    Large Cell Calcifying Sertoli Cell Tumor

    Intratubular Large Cell Hyalinizing Sertoli Cell Tumor

    Granulosa Cell Tumor

    Juvenile Granulosa Cell Tumor


    Testicular Tumor of Adrenogenital Syndrome

    Sex Cord-Stromal Tumor, Mixed/Unclassified


    Hematopoietic Tumors


    Tumors of Paratesticular Structures

    Adenomatoid Tumor

    Malignant Mesothelioma

    Adenocarcinoma of Rete Testis/Epididymis

    Epididymal Tumors

    Ovarian Epithelial-Type Tumors


    Melanotic Neuroectodermal Tumor


    Other Sarcomas

    Metastatic Tumors, Testis and Paratesticular Structures

    Metastatic Tumors, Testis and Paratesticular Structures

    Immunohistochemical Profiles for Tumors Involving Testis and Paratesticular Structures

    Immunohistochemistry, Testis

    Penis and Scrotum

    Frequent Lesions of Uncertain Relationship to Penile Neoplasia


    Lichen Sclerosus et Atrophicus

    Squamous Hyperplasia


    Scrotal Calcinosis

    Penile Intraepithelial Neoplasia

    Penile Intraepithelial Neoplasia

    Primary Epithelial Tumors

    General Concepts, Squamous Cell Carcinoma (Including Staging and Molecular Pathology)

    Squamous Cell Carcinoma, Usual Type

    Variants of Squamous Cell Carcinoma

    Basaloid Squamous Cell Carcinoma

    Basaloid Squamous Cell Carcinoma, Papillary Variant

    Warty (Condylomatous) Squamous Cell Carcinoma

    Warty-Basaloid Squamous Cell Carcinoma

    Verrucous Squamous Cell Carcinoma

    Papillary Squamous Cell Carcinoma, Not Otherwise Specified

    Pseudoglandular Squamous Cell Carcinoma

    Pseudohyperplastic Squamous Cell Carcinoma

    Cuniculatum Squamous Cell Carcinoma

    Sarcomatoid Squamous Cell Carcinoma

    Mixed Squamous Cell Carcinoma

    Undifferentiated to Poorly Differentiated Squamous Cell Carcinomas With Prominent Inflammatory Infiltrate

    Clear Cell Carcinoma

    HPV- and Non-HPV-Related Tumors

    Overview of HPV- and Non-HPV-Related Tumors

    Other Neoplastic Conditions

    Extramammary Paget Disease

    Kaposi Sarcoma


    Metastatic Tumors

    Metastatic Tumors, Penis

    Immunohistochemical Profiles for Tumors Involving Penis

    Immunohistochemistry, Penis

Product details

  • No. of pages: 1100
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: June 13, 2022
  • Imprint: Elsevier
  • Hardcover ISBN: 9780323763325

About the Authors

Mahul B. Amin

Mahul B. Amin, MD is the returning lead author from the previous edition. He is currently Professor and Chairman of Pathology at the University of Tennessee Health Science Center and the Endowed Chair for Cancer Research. His is board certified by the American Board of Pathology in both Anatomic and Clinical Pathology. Dr. Amin was the Editor in Chief of the 8th Edition AJCC TNM Staging Manual, as well as the Editor in Chief of Advances in Anatomic Pathology. His special research interests include urological cancer, quality assurance and improvement, laboratory medicine, and molecular pathology.

Affiliations and Expertise

Clinical Professor, Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center Memphis, Tennessee, Adjunct Professor, Department of Urology, University of Southern California, Keck School of Medicine, Los Angeles, California

Satish K. Tickoo

Affiliations and Expertise

Attending Pathologist, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York

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