Developmental and Fetal Origins of Differences in Monozygotic twins - 1st Edition - ISBN: 9780128200476

Developmental and Fetal Origins of Differences in Monozygotic twins

1st Edition

From Genetics to Environmental Factors

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Editors: Alexandra Matias Isaac Blickstein
Paperback ISBN: 9780128200476
Imprint: Academic Press
Published Date: 31st May 2020
Page Count: 368
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Description

Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout.

Key Features

  • Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management
  • Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis
  • Features contributions from international experts in twin genetics and developmental biology

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, pediatrics, fetal medicine, obstetrics and gynecology, reproductive biology, epidemiology, public health, bioinformatics, and endocrinology; life science researchers; oncologists; obstetricians; pediatricians; immunologists; bioengineers; developmental biologists

Table of Contents

1. The generation of MZ twins
Blickstein, Israel
2. Overview on the differences in MZ twins
Blickstein, Matias
3. Selective FGR in MZ twins
Gratacos E, Spain
4. Differences in hemoglobin levels /TAPS
Enrico Lopriore, The Netherlands
5. Epigenetics and differences in MZ twins
Tessa Homfray, UK
6. NIPT in MZ twins: does it spot the difference?
Samantha Leonard, USA
7. Placentation in MZ twins
Enrico Lopriore, The Netherlands
8. Differences in amniotic fluid /TTTS
Renato Sa, Brasil
9. Differences in fetal heart in MZ twins
Monique Haak, The Netherlands
10. Management of discordant anomalies in MZ twins
K. Nicolaides, UK
11. TRAP sequence
Liesbeth Levi, Belgium
12. The new imaging in MZ twins
Heron Werner, Jorge Lopes, Brasil
13. Heterokaryotypic twins
Liesbeth Levi, Belgium
14. Forensic issues in MZ twins
Mafalda Graça, Portugal
15. The importance of diet in MZ twins
Narcisa Bandarra, Portugal
16. Future directions in research of MZ twins
Blickstein, Matias

Details

No. of pages:
368
Language:
English
Copyright:
© Academic Press 2020
Published:
31st May 2020
Imprint:
Academic Press
Paperback ISBN:
9780128200476

About the Editor

Alexandra Matias

Dr. Alexandra Matias is Associate Professor of Obstetrics and Gynecology at Porto Medical School, and Senior Consultant in Obstetrics and Gynecology and Specialist in Fetal Medicine at University Hospital of S. João Porto, Portugal. Dr. Matias completed her PhD in Medicine at the University of Porto with the thesis "Venous return in the evaluation of fetal heart function,” and also completed a Alexander von Humboldt Stiftung Fellowship at the Pharmakologisches Institute in Heidelberg, Germany. She currently advises 6 doctorate and 12 master's degrees in Medicine, and served as the PhD jury president at the Faculty of Medicine of the University of Barcelona. Dr. Matias has published widely in such peer reviewed journals as Twin Research and Human Genetics, Ultrasound in Obstetrics and Gynecology, the Journal of Perinatal Medicine, the Journal of Fetal Diagnosis and Therapy, and the European Journal of Pharmacology.

Affiliations and Expertise

Associate Professor of Obstetrics and Gynecology (Porto Medical school) and Senior Consultant in Obstetrics and Gynecology (S. Joao hospital)

Isaac Blickstein

Isaac Blickstein is Associate Professor of Obstetrics and Gynaecology, Affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel

Affiliations and Expertise

Associate Professor of Obstetrics and Gynaecology, affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel

Ratings and Reviews