Developmental and Fetal Origins of Differences in Monozygotic Twins

Developmental and Fetal Origins of Differences in Monozygotic Twins

From Genetics to Environmental Factors

1st Edition - May 15, 2020

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  • Editors: Alexandra Matias, Isaac Blickstein
  • eBook ISBN: 9780128203071
  • Paperback ISBN: 9780128200476

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Description

Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout.

Key Features

  • Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management
  • Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis
  • Features contributions from international experts in twin genetics and developmental biology

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, pediatrics, fetal medicine, obstetrics and gynecology, reproductive biology, epidemiology, public health, bioinformatics, and endocrinology; life science researchers; oncologists; obstetricians; pediatricians; immunologists; bioengineers; developmental biologists

Table of Contents

  • 1. Introduction

    ALEXANDRA MATIAS

    2. Biology of monozygotic twinning

    ISAAC BLICKSTEIN

    3. Mechanisms of discordance in

    monozygotic twins: why and when?

    ALEXANDRA MATIAS, SARA SILVA AND

    ISAAC BLICKSTEIN

    of discordance 62

    Conclusion 73

    References 73

    Further reading 76

    4. Monozygotic twins in history:

    enlightenment by mythology and

    ethnography

    GIOVANNI CORSELLO AND ALEXANDRA MATIAS

    5. Genetics and epigenetics differences in

    monozygotic twins: the vision of the

    geneticist

    TESSA HOMFRAY

    6. Heterokaryotypic monozygotic twins

    LIESBETH LEWI, ISABEL COUCK AND JAN DEPREST

    7. Differences in placentation in

    monochorionic twin pregnancies

    SUZANNE F. DE VILLIERS, LISANNE TOLLENAAR

    8. Differences in growth: selective

    intrauterine growth restriction in

    monochorionic twins

    MAR BENNASAR AND EDUARD GRATACO´ S

    9. Hemoglobin differences at birth in

    monochorionic twins

    LIANNE VERBEEK AND ENRICO LOPRIORE

    10. Differences in amniotic fluid in MZ

    twins

    RENATO AUGUSTO MOREIRA DE SA´ , PAULO ROBERTO

    NASSAR DE CARVALHO AND LUI´SA MOREIRA DE A ´ VILA

    11. Twin-reversed arterial perfusion

    sequence: different identical twins

    LIESBETH LEWI, ISABEL COUCK AND JAN DEPREST

    12. Major discordant anomalies in

    monozygotic twins: management and

    outcome

    DANIELA CASATI, STEFANO FAIOLA AND

    MARIANO LANNA

    13. Congenital heart disease in

    monozygotic twins

    MANON GIJTENBEEK AND MONIQUE HAAK

    14. Spotting the differences in the

    first trimester of pregnancy in MZ twins:

    the issue of aneuploidies and TTTS

    screening

    ALEXANDRA MATIAS, MIGUEL PEREIRA MACEDO AND

    NUNO MONTENEGRO

    15. Noninvasive prenatal screening in

    twin pregnancies

    SAMANTHA LEONARD AND KIMBERLY MARTIN

    16. A new way to look at multiples: the

    power of image

    HERON WERNER JR, JORGE LOPES AND

    MIGUEL PEREIRA MACEDO

    17. Differences in monozygotic twins: the

    implications of diet and intestinal

    microbioma

    CARLOS CARDOSO, CLA´ UDIA AFONSO AND

    NARCISA M. BANDARRA

    18. Differences in development in

    monozygotic twins

    NANCY L. SEGAL, JOSEPH L. NEDELEC AND

    VANESSA A. COSTELLO-HARRIS

    19. Monozygotic twins: a personal as

    well as a criminal and jurisdictional

    approach

    MAFALDA GAGLIARDINI GRAC¸ A

    20. Monozygotic twin differences in

    perceived age

    MIKAEL THINGGAARD AND KAARE CHRISTENSEN

    21. The environmental differences

    between twins in utero and their

    importance for downstream development: a

    need for standardized monitoring in

    obstetric research

    JEFFREY M. CRAIG, EMMA K. SUTTON AND

    SHAYESTEH JAHANFAR

    22. Future perspectives

    ISAAC BLICKSTEIN

Product details

  • No. of pages: 386
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: May 15, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128203071
  • Paperback ISBN: 9780128200476

About the Editors

Alexandra Matias

Dr. Alexandra Matias is Associate Professor of Obstetrics and Gynecology at Porto Medical School, and Senior Consultant in Obstetrics and Gynecology and Specialist in Fetal Medicine at University Hospital of S. João Porto, Portugal. Dr. Matias completed her PhD in Medicine at the University of Porto with the thesis "Venous return in the evaluation of fetal heart function,” and also completed a Alexander von Humboldt Stiftung Fellowship at the Pharmakologisches Institute in Heidelberg, Germany. She currently advises 6 doctorate and 12 master's degrees in Medicine, and served as the PhD jury president at the Faculty of Medicine of the University of Barcelona. Dr. Matias has published widely in such peer reviewed journals as Twin Research and Human Genetics, Ultrasound in Obstetrics and Gynecology, the Journal of Perinatal Medicine, the Journal of Fetal Diagnosis and Therapy, and the European Journal of Pharmacology.

Affiliations and Expertise

Associate Professor of Obstetrics and Gynecology (Porto Medical school) and Senior Consultant in Obstetrics and Gynecology (S. Joao hospital)

Isaac Blickstein

Isaac Blickstein is Associate Professor of Obstetrics and Gynaecology, Affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel

Affiliations and Expertise

Associate Professor of Obstetrics and Gynaecology, affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel

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