Development of the Nervous System

Development of the Nervous System

4th Edition - June 13, 2019

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  • Authors: Dan Sanes, Thomas Reh, William Harris, Matthias Landgraf
  • eBook ISBN: 9780128040287
  • Hardcover ISBN: 9780128039960

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Development of the Nervous System, Fourth Edition provides an informative and up-to-date account of our present understanding of the basic principles of neural development as exemplified by key experiments and observations from past and recent times. This book reflects the advances made over the last few years, demonstrating their promise for both therapy and molecular understanding of one of the most complex processes in animal development. This information is critical for neuroscientists, developmental biologists, educators, and students at various stages of their career, providing a clear presentation of the frontiers of this exciting and medically important area of developmental biology. The book includes a basic introduction to the relevant aspects of neural development, covering all the major topics that form the basis of a comprehensive, advanced undergraduate and graduate curriculum, including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and plasticity.

Key Features

  • Provides broad coverage of concepts and experimental strategies
  • Includes full color schematics and photographs of critical experiments
  • Outlines the molecular and genetic basis for most developmental events
  • Written at a level that is appropriate for advanced undergraduates and beyond
  • Includes designs of critical experiments that are easy to understand


Neuroscientists, development neuroscience researchers and educators, advanced undergraduate to graduate level students

Table of Contents

  • 1. Neural Induction
    2. Polarity and Segmentation
    3. Genesis and Migration
    4. Generation of Neural Diversity
    5. Wiring up the Brain: Axon Navigation
    6. Differentiation
    7. Naturally-Occurring Neuron Death
    8. Synapse Formation
    9. Refinement of Synaptic Connections
    10. Behavioral Development

Product details

  • No. of pages: 390
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: June 13, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128040287
  • Hardcover ISBN: 9780128039960

About the Authors

Dan Sanes

Dr. Sanes is Professor in the Center for Neural Science and Department of Biology at New York University. Named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010 for his research in auditory central nervous system development, his research has been supported by the National Institute on Deafness and Other Communication Disorders and the National Science Foundation. His lab studies synaptic plasticity and central auditory processing, and the phenomenon of hearing loss during development.

Affiliations and Expertise

Professor, Center for Neural Science and Department of Biology, New York University, NY, USA

Thomas Reh

Dr. Reh is Professor of Biological Structure and Director of the Neurobiology and Behavior Program at the University of Washington. He is currently a member of the Scientific Advisory Board of the Foundation Fighting Blindness, and of a start-up biotechnology company, Acucela. He has received several awards for his work, including the AHFMR and Sloan Scholar awards and has published over 100 journal articles, reviews and books. Funded by numerous N.I.H. and private foundation grants, his lab is focused on the development and repair of the retina, with an overall goal of understanding the cellular and molecular biology of regeneration in the eye.

Affiliations and Expertise

Professor of Biological Structure and Director of the Neurobiology and Behavior Program, University of Washington, Seattle, USA

William Harris

Dr. Harris is co-chair of Cambridge Neuroscience and Director of Studies in Neuroscience. He is also Head of the Department of Physiology, Development, and Neuroscience, and is Professor of Anatomy. Elected a Fellow of the Royal Society of London in 2007, he was Professor of Biology at UCSD prior to accepting a position at Cambridge. His lab is working to elucidate the cellular and molecular events that are used to push or induce cells to transition from proliferating stem cells to differentiated neurons and glia, and how particular regions of the nervous system produce the right number of neurons and the right proportions of different neuron subtypes.

Affiliations and Expertise

Head of the Department of Physiology, Development, and Neuroscience, Professor of Anatomy, University of Cambridge, UK

Matthias Landgraf

Matthias Landgraf studied Genetics at University College London and completed his PhD research on nervous system development at the University of Cambridge. He was a Royal Society University Research Fellow at Cambridge and is currently a Reader (Associate Professor) in Developmental Neurobiology at the Department of Zoology and fellow of Jesus College, University of Cambridge, working on the emergence of synaptic specificity in motor systems.

Affiliations and Expertise

Reader (equivalent to Associate Professor) in Developmental Neurobiology, Department of Zoology, University of Cambridge, UK Fellow of Jesus College, University of Cambridge, UK

Ratings and Reviews

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  • BoZhang Mon Feb 24 2020


    Nice book with great quality.

  • FatimaAdrio Mon Sep 16 2019

    Development of the nervous system

    In my opinion, the fourth edition of this book, as well as all the previous ones, is a reference text for all those interested in the field of the nervous system development. Moreover, the illustrations are of great quality and very useful when interpreting the explanations of the text. Undoubtedly, essential for developmental neuroscientists and Neuroscience master students.

  • MohammedHisham Sun Jul 21 2019

    Development of the nervous system

    Excellent book and uptodate

  • MohammedHisham Sun Jul 21 2019

    Development of the nervous system

    Excellently revised book but larger in size than previous editions!