Designing Antibodies

Designing Antibodies

1st Edition - July 8, 1993

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  • Author: Ruth Mayforth
  • eBook ISBN: 9780323160025

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Description

Designing Antibodies provides a compilation of research in the design of antibodies. It describes the techniques used in antibody design, the kinds of antibodies generated through modern techniques, and their applications in medicine and science. The book begins with an overview of the humoral immune system and of antibody structure, function, and biosynthesis, which sets the stage for the subsequent discussions of developments in antibody technology. The remaining chapters discuss the making of monoclonal antibodies; the design of antibodies for human therapy; the connection of antibodies (either chemically or genetically) to other potentially therapeutic effector molecules such as toxins, enzymes, or even an antibody of another specificity; idiotypes and anti-idiotypic antibodies; and the ability of antibodies to functionally mimic enzymes and mediate catalysis. It is hoped that, in addition to illustrating the progress of research in antibody design, the various creative and innovative approaches reviewed in this book will be modified or will stimulate new ideas that will spur the research and application of designer antibodies.

Table of Contents


  • Preface

    1. Antibody Overview

    Introduction

    The Humoral Immune System

    Antibody Structure

    Functions of Antibodies

    Biosynthesis of Immunoglobulins

    References

    2. Making Monoclonal Antibodies

    Hybridoma Technology

    Making Human Monoclonal Antibodies

    Generating Transfectomas

    Immunoglobulin Gene Expression Librarians

    Generating Epitope Libraries

    References

    3. Designing Antibodies for Human Therapy

    Introduction

    Genetically Engineered Rodent-Human Antibodies

    Genetically Engineered Antibodies Lacking Fc Reactivity

    Novel Recombinant Antibody Fusion Proteins

    Summary

    References

    4. Antibody Targeting

    Introduction

    Immunotoxins

    Antibody-Effector Molecule Conjugates

    Antibodies with Dual Specificities

    Antibody-Targeted Liposomes

    Summary

    References

    5. Idiotypes and Anti-idiotypic Antibodies

    Idiotypes and the Idiotype Network

    Applications of Anti-idiotypic Antibodies

    Summary and Prospectus

    References

    6. Catalytic Antibodies

    Introduction

    Enzyme Kinetics and Transition-State Theory

    Catalytic Antibodies

    Summary

    References

    Appendix

    Index




Product details

  • No. of pages: 216
  • Language: English
  • Copyright: © Academic Press 1993
  • Published: July 8, 1993
  • Imprint: Academic Press
  • eBook ISBN: 9780323160025

About the Author

Ruth Mayforth

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