Dendritic Cells

2nd Edition

Biology and Clinical Applications

Editors: Michael Lotze Angus Thomson
Hardcover ISBN: 9780124558519
eBook ISBN: 9780080491073
Imprint: Academic Press
Published Date: 20th August 2001
Page Count: 794
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Dendritic Cells, 2nd Edition is the new edition of the extremely successful book published in 1998. With the volume of literature on dendritic cells doubling every year, it is almost impossible to keep up. This book provides the most up-to-date synthesis of the literature, written by the very best authors. It is essential reading for any scientist working in immunology, cell biology, infectious diseases, cancer, transplantation, genetic engineering, or the pharmaceutical/biotechnology industry.

Key Features

  • An entirely new section on DC biology is included in this edition. Also new to this edition are chapters on:
  • Imaging
  • Interaction of dendritic cells with viruses
  • Dendritic cells and dendrikines, chemokines and the endothelium
  • Molecules expressed in dendritic cells
  • Role of dendritic cells in wound healing and atherosclerosis
  • Delivery of apoptotic bodies
  • Genetic engineering of dendritic cells
  • Imaging
  • Practical aspects of clinical protocol development


Researchers and clinicians in immunology, cancer biology, cell biology, infectious disease, autoimmunity, virology, transplantation, and genetic engineering.

Table of Contents

Preface Michael T Lotze and Angus W Thomson

Foreword Dendritic Cells in Biology and Disease Sir Gustav JV Nossal, FRS


Chapter 1 The Development of Dendritic Cells from Hematopoietic Precursors Li Wu and Anne Galy

Chapter 2 Dendritic Cells in the Thymus Hergen Spits

Chapter 3 T cell activation and polarization by dendritic cells Yong Jung Liu, Vassilli Soumelis and Nori Kadowaki

Chapter 4 Follicular Dendritic Cells: Molecules Associated with Function Marie Kosco-Vilbois

Chapter 5 Langerhans Cells Dieter Maurer and Georg Stingl

Chapter 6 Dendritic cell-related immunoregulation: signals and mediators Pawel Kalinski, Martien L. Kapsenberg, Michael T.Lotze


Chapter 7 A Guide to the Isolation, Culture and Propagation of Dendritic Cells Weiping Zou, Jozef Borvak, Florentina Marches, Shuang Wei, Tatyana Isaeva, Tyler J. Curiel

Chapter 8 Phenotypic Characterization of Dendritic Cells Derek N J Hart, Kelli MacDonald, Slavica Vuckovic and Georgina J Clark

Chapter 9 Targeted Gene Knockouts: Making sense of dendritic cell biology and lymphoid tissue development David Lo, Lian Fan, Will Redmond and Christina R. Reilly

Chapter 10 Mobilization, Migration, and Localization of Dendritic Cells Jonathan M Austyn

Chapter 11 Regulation of Antigen Capture, MHC Biosynthesis and Degradation by Dendritic Cells Russell D Salter and Xin Dong<BR id="CRLF


No. of pages:
© Academic Press 2001
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editor

Michael Lotze

Affiliations and Expertise

Departments of Surgery and Bioengineering, University of Pittsburgh Cancer Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA

Angus Thomson

Affiliations and Expertise

Departments of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA


"This is an excellent book that will serve as a valuable source of information for many researchers both in and outside the field of dendritic cell biology. The scope and range of information in this book make it a significant contribution to the scientific literature. The fact that this second edition was published only three years after the first edition speaks to the importance and vitality of the dendritic cell biology field." Alvin Telser for DOODY'S (2003) Praise for the First Edition "...represents the first book that attempts to draw together the exponential growth in our knowledge about this fundamental cell." -IMMUNOLOGY TODAY (March 2000)