Dendritic Cells

Dendritic Cells

Biology and Clinical Applications

2nd Edition - August 20, 2001

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  • Editors: Michael Lotze, Angus Thomson
  • Hardcover ISBN: 9780124558519
  • eBook ISBN: 9780080491073

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Dendritic Cells, Second Edition is the new edition of the extremely successful book published in 1998. With the volume of literature on dendritic cells doubling every year, it is almost impossible to keep up. This book provides the most up-to-date synthesis of the literature, written by the very best authors. It is essential reading for any scientist working in immunology, cell biology, infectious diseases, cancer, transplantation, genetic engineering, or the pharmaceutical/biotechnology industry.

Key Features

An entirely new section on DC biology is included in this edition. Also new to this edition are chapters on:

  • Imaging
  • Interaction of dendritic cells with viruses
  • Dendritic cells and dendrikines, chemokines and the endothelium
  • Molecules expressed in dendritic cells
  • Role of dendritic cells in wound healing and atherosclerosis
  • Delivery of apoptotic bodies
  • Genetic engineering of dendritic cells
  • Imaging
  • Practical aspects of clinical protocol development


Researchers and clinicians in immunology, cancer biology, cell biology, infectious disease, autoimmunity, virology, transplantation, and genetic engineering

Table of Contents

  • Preface Michael T Lotze and Angus W Thomson

    Foreword Dendritic Cells in Biology and Disease
    Sir Gustav JV Nossal, FRS


    Chapter 1 The Development of Dendritic Cells from Hematopoietic Precursors
    Li Wu and Anne Galy

    Chapter 2 Dendritic Cells in the Thymus
    Hergen Spits

    Chapter 3 T cell activation and polarization by dendritic cells
    Yong Jung Liu, Vassilli Soumelis and Nori Kadowaki

    Chapter 4 Follicular Dendritic Cells: Molecules Associated with Function
    Marie Kosco-Vilbois

    Chapter 5 Langerhans Cells
    Dieter Maurer and Georg Stingl

    Chapter 6 Dendritic cell-related immunoregulation: signals and mediators
    Pawel Kalinski, Martien L. Kapsenberg, Michael T.Lotze


    Chapter 7 A Guide to the Isolation, Culture and Propagation of Dendritic Cells
    Weiping Zou, Jozef Borvak, Florentina Marches, Shuang Wei, Tatyana Isaeva, Tyler
    J. Curiel

    Chapter 8 Phenotypic Characterization of Dendritic Cells
    Derek N J Hart, Kelli MacDonald, Slavica Vuckovic and Georgina J Clark

    Chapter 9 Targeted Gene Knockouts: Making sense of dendritic cell biology and lymphoid tissue development
    David Lo, Lian Fan, Will Redmond and Christina R. Reilly

    Chapter 10 Mobilization, Migration, and Localization of Dendritic Cells
    Jonathan M Austyn

    Chapter 11 Regulation of Antigen Capture, MHC Biosynthesis and Degradation by Dendritic Cells
    Russell D Salter and Xin Dong

    Chapter 12 Development and Testing of Dendritic Cells Lines
    Akira Takashima and Hiroyuki Matsue

    Chapter 13 Dendritic Cell-derived Exosomes: Potent Immunogenic Cell-Free Vaccines
    Clotilde Thery, Joseph Wolfers, Armelle Regnault, Fabrice Andre, Nadine Fernandez, Graca Raposo, Sebastian Amigorena, and Laurence Zitvogel

    Chapter 14 Dendritic Cells as Recipients of Cytokine Signals
    Jonathan Cebon, Ian Davis, Thomas Luft and Eugene Maraskovsky

    Chapter 15 Dendritic Cells and Chemokines
    Silvano Sozzani, Paola Allavena and Alberto Mantovani

    Chapter 16 Studies of Endocytosis
    Wendy S. Garrett and Ira Mellman

    Chapter 17 Imaging of Dendritic Cells
    Glenn D. Papworth, Donna Beer Stolz, Simon C. Watkins


    Chapter 18 NK Cells
    Nadine C. Fernandez, Carole Masurier, Magali Terme, Joseph Wolfers, Eugenen
    Maraskovsky and Laurence Zitvogel

    Chapter 19 A Direct role of Dendritic Cells in the regulation of Humoral Response
    Francine Brière, Bertrand Dubois, Jerome Fayette, Stephane Vandenabeele, Christophe Caux and Jacques Banchereau

    Chapter 20 Dendritic Cells and Cells of the Monocyte/Macrophage Lineage
    Thomas C. Manning and Thomas F. Gajewski

    Chapter 21 Dendritic Cells and Endothelium
    Gwendalyn J. Randolph

    Chapter 22 Dendritic Cell/Dendritic Cell Interaction
    Stella C Knight and Penelope A Bedford


    Chapter 23 Dendritic Cells in the Context of Skin Immunity
    Adriana T. Larregina and Louis D. Falo Jr.

    Chapter 24 Dendritic Cells in the Respiratory Tract
    Laurent P. Nicod and L. Cochand

    Chapter 25 Intestinal Dendritic Cells
    G. Gordon MacPherson, Fang-Ping Huang and LiMing Liu

    Chapter 26 Dendritic Cells in the Liver, Kidney, Heart, and Pancreas
    Raymond J. Steptoe, Peta J. O'Connell and Angus W. Thomson

    Chapter 27 Dendritic Cells in the Spleen and Lymph Node
    Bali Pulendran, Karolina Palucka, Jacques Banchereau

    Chapter 28 Dendritic Cells in the Central Nervous System
    Francesca Aloisi, Barbara Serafini, Sandra Columba-Cabezas, and Luciano Adorini

    Chapter 29 Dendritic Cells and the Eye
    John V. Forrester and Paul G. McMenamin

    Chapter 30 Dendritic Cells in the Reproductive Tract
    C. Allen Black, Michael Murphy-Corb


    Chapter 31 The Identification of Human Dendritic Cells in Situ in Fixed Tissues
    Michael T. Lotze and Ronald Jaffe

    Chapter 32 Dendritic Cells in Rejection and Acceptance of Solid Organ Allografts
    Anthony J Demetris, N Murase, JJ Fung, TE Starzl

    Chapter 33 Dendritic Cells in Autoimmunity
    Ranjeny Thomas

    Chapter 34 Interaction of Dendritic Cells with Bacteria
    M. Rescigno, M. Urbano, M. Rittig, S. Citterio, B. Valzasina, F. Granucci, and Paola

    Chapter 35 Dendritic Cells during Infection with HIV-1 and SIV
    R. Ignatius, R.M. Steinman, A.Granelli-Piperno, D. Messmer, C. Stahl-Hennig, K.
    Tenner-Racz, P. Racz, I. Frank, L Zhong, S. Schlesinger Frankel, and Melissa

    Chapter 36 Interaction of viruses with Dendritric Cells
    Marie Larsson, Jean Francois Fonteneau, Andrew Lee, Nina Bhardwaj

    Chapter 37 Dendritic Cells in Allergy
    AE Semper, AM Gudin, JA Holloway and ST Holgate

    Chapter 38 DCs in Wound Healing
    Kristine Kikly, Michael T. Lotze

    Chapter 39 Dendritic Cells in Atherosclerosis
    Yuri V. Bobryshev


    Chapter 40 Clinical Trials of Dendritic Cells for Cancer
    Jeff Weber and Larry Fong

    Chapter 41 Dendritic Cell Therapies of HIV-1 Infection
    Cara C. Wilson

    Chapter 42 Dendritic Cells Tolerogenicity and Prospects for Dendritic Cell-Based Therapy of Allograft Rejection and Autoimmune disease
    Lina Lu and Angus W. Thompson

    Chapter 43 Genetic Engineering of Dendritic Cells
    Andrea Gambotto, VR Cicinnati and PD Robbins

    Chapter 44 Resurrecting the Dead: phagocytosis of apoptotic cells by dendritic cells results in the cross-presentation of exogenous antigen
    Matthew L Albert

    Chapter 45 Dendritic Cells and the Biology of Parasitism
    Karen A Norris

    Annotated References by Year

Product details

  • No. of pages: 794
  • Language: English
  • Copyright: © Academic Press 2001
  • Published: August 20, 2001
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124558519
  • eBook ISBN: 9780080491073

About the Editors

Michael Lotze

Affiliations and Expertise

Departments of Surgery and Bioengineering, University of Pittsburgh Cancer Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA

Angus Thomson

Affiliations and Expertise

Departments of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA

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