Description

Bioresorbable materials are extensively used for a wide range of biomedical applications from drug delivery to fracture fixation, and may remain in the body for weeks, months or even years. Accurately predicting and evaluating the degradation rate of these materials is critical to their performance and the controlled release of bioactive agents. Degradation rate of bioresorbable materials provides a comprehensive review of the most important techniques in safely predicting and evaluating the degradation rate of polymer, ceramic and composite based biomaterials.

Part one provides an introductory review of bioresorbable materials and the biological environment of the body. Chapters in Part two address degradation mechanisms of commonly used materials such as polymers and ceramics. This is followed by chapters on bioresorption test methods and modelling techniques in Part three. Part four discusses factors influencing bioresorbability such as sterilisation, porosity and host response. The final section reviews current clinical applications of bioresorbable materials.

With its distinguished editor and multidisciplinary team of international contributors, Degradation rate of bioresorbable materials: prediction and evaluation provides a unique and valuable reference for biomaterials scientists, engineers and students as well as the medical community.

Key Features

  • Comprehensively reviews the most pertinent techniques in safely predicting and evaluating the degradation rate of bioresorbable materials
  • Addresses degradation mechanisms of commonly used materials
  • Discusses factors influencing bioresorbability such as sterilisation and host response

Readership

Biomaterials scientists; Engineers; Students and academics in this field

Table of Contents

Part 1 Introduction: An overview of bioresorbable materials; The biological environment for bioresorbable materials. Part 2 Degradation mechanisms: Synthetic bioresorbable polymers; Natural bioresorbable polymers; Bioresorbable ceramics. Part 3 Bioresorption test methods: In-vitro physicochemical test methods to evaluate bioresorbability; In-vitro biological test methods to evaluate bioresorbability; In-vivo test methods to evaluate bioresorbability; Modelling of the degradation processes for bioresorbable polymers. Part 4 Factors influencing bioresorption: Influence of processing, sterilisation and storage on bioresorbability; Influence of porous structure on bioresorbability: Tissue engineering scaffolds. Part 5 Clinical application: Influence of clinical application on bioresorbability: Host response; Scaffold and implant design: Considerations relating to characterization of biodegradibility and bioresorbability; Drug release from bioresorbable materials.

Details

No. of pages:
424
Language:
English
Copyright:
© 2008
Published:
Imprint:
Woodhead Publishing
Electronic ISBN:
9781845695033
Print ISBN:
9781845693299

About the editor

F J Buchanan

Dr Fraser Buchanan is a Senior Lecturer in the School of Mechanical and Aerospace Engineering at Queens University Belfast. He is highly regarded for his expertise in developing and testing synthetic biomaterials.