Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight to yield an understanding of how the chemistry drives the properties. Degenerate ring transformations of heterocycles are classified as reactions in which a heterocyclic system is converted into the same heterocyclic system. This monograph covers an authoritative, comprehensive overview of a host of degenerate ring transformations in five- and six-membered heterocycles. It shows how by the use of 15N-labeled, 13C-labeled, or selectively substituted compounds these degenerate rign transformations can be discovered and how most of the results can be explained by the Addition Nucleophile, Ring Opening, and Ring Closure [ANRORC] mechanism. Another main topic of the monograph is the occurrence of degenerate ring transformations.
Organic chemists, pharmacologists, medicinal chemists, photographic chemists, and agrochemists.
Introduction. SN (ANRORC) Reactions in Azines, Containing an "Outside" Leaving Group. The Discovery of the SN (ANRORC) Concept. SN(ANRORC) Substitutions in Mono Azines. SN(ANRORC) Substitutions in Dlazines. SN(ANRORC) Substitutions in Triazines and Tetrazines. SN (ANRORC) Reactions in Azaheterocycles, Containing an "Inside" Leaving Group. Degenerate Ring transformations, Involving the Replacement of the Nitrogen of the Azaheterocycle by Nitrogen of the Reagent. Degenerate Ring Transformations, Involving the Replacement of a C-N Fragment of the Pyrimidine Ring by a C-N Moiety of a Reagent. Degenerate Ring Transformations, Involving the Replacement of a Three-Atom Fragement of the Heterocyclic Ring by a Three-Atom Moiety of a Reagent. Degenerate Ring Transformation, Involving the Replacement of a Carbon Atom of the Heterocyclic Ring by a Carbon Atom of the Reagents. Degenerate Ring Transformations by Side-Chain Participation. Introduction. Degenerate Ring Transformations, Involving the Participation of a Side-Chain with One Atom. Degenerate Ring Transformations, Involving the Participation of a Side-Chain with Two Atoms. Degenerate Ring Transformations, Involving the Participation of a Side-Chain with Three Atoms.
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- © Academic Press 1999
- 21st July 1999
- Academic Press
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@from:Praise for the Series @qu:"The typesetting, arrangement of references, and drafting of structural formulas adhere to the high standards of this series and provide a model for good publishing....The content is, as to be expected, excellent." @source:--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY