Cytodifferentiation and Macromolecular Synthesis

Cytodifferentiation and Macromolecular Synthesis

1st Edition - January 1, 1963

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  • Editor: Michael Locke
  • eBook ISBN: 9780323157568

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Cytodifferentiation and Macromolecular Synthesis focuses on research on biosynthesis, structure, and morphology of cells. The book first discusses cytodifferentiation and macromolecular synthesis and genetic control of protein structure. The relationship of amino acid substitutions to the genetic code; comparison of gene and protein alterations; and suppressor mutations are described. The text also looks at genetic repression, allosteric inhibition, and cellular differentiation; epigenetic control of protein synthesis in cells; quantitative studies of protein synthesis in embryonic tissues; and chromosomes and cytodifferentiation. The book also discusses the morphological and chemical differentiation of plastids. The effect of light on plastid development; structure of mature chloroplast; morphological changes in the development of proplastid to the chloroplast; and inheritable factors that control plastids are described. The text also focuses on the collagen system, mechanisms of elongation, and tissue interaction and metabolic responses. The book is a valuable reference for readers wanting to conduct research on the complex nature of cells.

Table of Contents

  • List of Contributors


    Cytodifferentiation and Macromolecular Synthesis

    Genetic Control of Protein Structure

    Characteristics of the Gene-Protein System Selected for Study

    Comparison of Gene Alterations and Protein Alterations

    The Relationship of Amino Acid Substitutions to the Genetic Code

    Suppressor Mutations—Alterations of the Translation Mechanism

    Genetic Repression, Allosteric Inhibition, and Cellular Differentiation


    Regulation of Enzymatic Activity: Allosteric Effects

    Regulation of Protein Synthesis in Bacteria

    Negative Regulation Controlled by Specific Genetic Determinants

    Operators and Polygenic Operons

    Messenger RNA and Regulation at the Genetic Level

    The Repressor

    Genetic Regulation and Differentiation

    Model Circuits


    Epigenetic Control of Specific Protein Synthesis in Differentiating Cells


    Physicochemical Nature of LDH

    Subunit Hypothesis

    Chemical Composition

    Immunochemical Properties

    Function of Isozymes

    Quantitative Studies of Protein Synthesis in Some Embryonic Tissues

    Protein Synthesis in the Explanted Chick Embryo

    Protein Synthesis in Differentiating Tissues during Late Development

    Chromosomes and CytodifFerentiation

    Structural Considerations

    Loops, Puffs, and Genes

    Heterogeneity of Nuclear RNA

    RNA Synthesis in Lampbrush Chromosome Loops

    Control of Chromosomal Synthesis


    Concluding Remarks

    The Plastids: Their Morphological and Chemical Differentiation


    Structure of the Mature Chloroplast

    Relation of Chloroplast Structure to Photosynthetic Function

    Morphological Changes in the Development of the Proplastid to the Chloroplast

    The Effect of Light on Plastid Development

    Chlorophyll Biosynthesis in the Developing Plastid

    Inheritable Factors That Control the Plastids

    Cytoplasmic Inheritance of Euglena Plastids

    Origin of Plastid Types


    Organization and Disorganization of Extracellular Substances: The Collagen System

    Organization of Collagen

    Experimental Lathyrism

    Collagen Degradation in Animal Tissues

    On Mechanisms of Elongation

    Axis Extension Related to Ordered Synthesis of Cell Wall

    Significance of Transverse Wall Texture in Elongation in Nitella

    Polarized Light Microscopy

    Peculiar Optical Properties of Elongating Cell Walls

    Evidence for a Cytoplasmic Framework

    The Cytoplasmic Framework—Its Action in Orienting Synthesis

    Influences on the Orientation of the Cytoplasmic Framework

    Role of Strain in the Orientation of the Cytoplasmic Framework

    Nature of the Rectifying Mechanism

    A Provisional Model



    Tissue Interaction and Specific Metabolic Responses: Chondrogenic Induction and Differentiation

    Experimental Modification of Degrees of Differentiation Manifested by Tissue Dissociation and Short-Term Re-aggregation

    An Apparently Anomalous Instance of Chondrogenesis in Explants of Embryonic Mesonephros

    A More Detailed Account of the Interactions Involved in the Induction of Vertebral Cartilage


    Author Index

    Subject Index

Product details

  • No. of pages: 286
  • Language: English
  • Copyright: © Academic Press 1963
  • Published: January 1, 1963
  • Imprint: Academic Press
  • eBook ISBN: 9780323157568

About the Editor

Michael Locke

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