Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528232, 9781483217222

Current Topics in Cellular Regulation, Volume 23

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217222
Imprint: Academic Press
Published Date: 1st February 1984
Page Count: 278
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Table of Contents


Contributors


Pyruvate Carboxylase


I. Introduction


II. Structural Studies


III. Studies on the Mechanism of Action


IV. Carboxylation of Biotin


V. Translocation of Biotin Between the Two Subsites


VI. Carboxylation of Pyruvate


VII. Detailed Description of the Steady-State Mechanism


VIII. Participation of the Allosteric Activator Acetyl-CoA


IX. Conclusion


References


The Role of Fructose 2,6-Bisphosphate in the Regulation of Carbohydrate Metabolism


I. Introduction


II. Discovery and Identification of Fructose 2,6-P2


III. Regulation of Fructose 2,6-P2 Levels


IV. Regulation of Enzyme Activity by Fructose 2,6-P2


V. Regulation of Hepatic Carbohydrate Metabolism by Fructose 2,6-P2


References


Plasma Membrane ATPase of Fungi and Plants as a Novel Type of Proton Pump


I. Introduction


II. In Vivo Studies on the Proton Pumps of Fungi and Plants


III. ATPase and Proton Transport in Isolated Plasma Membranes


IV. Purification and Reconstitution of the Proton-Pumping ATPase


V. Conclusions and Perspectives


References


Adrenergic Control of Phosphofructokinase and Glycolysis in Rat Heart


I. Introduction


II. Adrenergic Regulation of PFK in Liver and Muscle


III. Properties of the Epinephrine-Activated Form of Heart PFK


IV. Adrenergic Receptors Involved in the Activation of Heart PFK


V. Molecular Mechanisms


VI. Deactivase


VII. The Role of Adrenergic Control of PFK in Cardiac Glycolysis


VIII. Obesity and the Adrenergic Regulation of Cardiac PFK and Glucose Metabolism


IX. The Functional Significance of Adrenergic Control of PFK and


Description

Current Topics in Cellular Regulation: Volume 23 is a collection of papers that discusses pyruvate carboxylase, the regulation of carbohydrate metabolism, and the plasma membrane ATPase of fungi or plants. Other papers deal with adrenergic control of phosphofructokinase, protein phosphatase, as well as the regulation of polypeptide precursors of mature mitochondrial proteins. One paper explains the three dimensional structure of pyruvate carboxylase and its reaction mechanism. Electron microscopic analyses show that four monomers of pyruvate carboxylases isolated from vertebrate sources form a tight tetrahedron-like structure. Another paper describes the regulation of fructose 2,6-bisphosphate concentration in the liver and of the enzymes that are responsible for its metabolism, and the mechanism involved in fructose, particularly in the regulation of 6-phosphofructo-1-kinase and fructose-1,6-bisphosphatase activity. The paper also explains the role of this effector in the regulation of hepatic carbohydrate metabolism. One paper deals with the different levels of biological organization (whole cells, isolated plasma membranes, and purified enzyme) that characterizes the plasma membrane ATPase of fungi and plants as a novel type of proton pump. The collection can prove useful for biologists, microbiologists, students, and professors of biology and biophysics.


Details

No. of pages:
278
Language:
English
Copyright:
© Academic Press 1984
Published:
Imprint:
Academic Press
eBook ISBN:
9781483217222

Ratings and Reviews


About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor