Current Topics in Cellular Regulation

Current Topics in Cellular Regulation

1st Edition - February 1, 1984

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  • Editors: Bernard L. Horecker, Earl R. Stadtman
  • eBook ISBN: 9781483217222

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Current Topics in Cellular Regulation: Volume 23 is a collection of papers that discusses pyruvate carboxylase, the regulation of carbohydrate metabolism, and the plasma membrane ATPase of fungi or plants. Other papers deal with adrenergic control of phosphofructokinase, protein phosphatase, as well as the regulation of polypeptide precursors of mature mitochondrial proteins. One paper explains the three dimensional structure of pyruvate carboxylase and its reaction mechanism. Electron microscopic analyses show that four monomers of pyruvate carboxylases isolated from vertebrate sources form a tight tetrahedron-like structure. Another paper describes the regulation of fructose 2,6-bisphosphate concentration in the liver and of the enzymes that are responsible for its metabolism, and the mechanism involved in fructose, particularly in the regulation of 6-phosphofructo-1-kinase and fructose-1,6-bisphosphatase activity. The paper also explains the role of this effector in the regulation of hepatic carbohydrate metabolism. One paper deals with the different levels of biological organization (whole cells, isolated plasma membranes, and purified enzyme) that characterizes the plasma membrane ATPase of fungi and plants as a novel type of proton pump. The collection can prove useful for biologists, microbiologists, students, and professors of biology and biophysics.

Table of Contents

  • Contributors

    Pyruvate Carboxylase

    I. Introduction

    II. Structural Studies

    III. Studies on the Mechanism of Action

    IV. Carboxylation of Biotin

    V. Translocation of Biotin Between the Two Subsites

    VI. Carboxylation of Pyruvate

    VII. Detailed Description of the Steady-State Mechanism

    VIII. Participation of the Allosteric Activator Acetyl-CoA

    IX. Conclusion


    The Role of Fructose 2,6-Bisphosphate in the Regulation of Carbohydrate Metabolism

    I. Introduction

    II. Discovery and Identification of Fructose 2,6-P2

    III. Regulation of Fructose 2,6-P2 Levels

    IV. Regulation of Enzyme Activity by Fructose 2,6-P2

    V. Regulation of Hepatic Carbohydrate Metabolism by Fructose 2,6-P2


    Plasma Membrane ATPase of Fungi and Plants as a Novel Type of Proton Pump

    I. Introduction

    II. In Vivo Studies on the Proton Pumps of Fungi and Plants

    III. ATPase and Proton Transport in Isolated Plasma Membranes

    IV. Purification and Reconstitution of the Proton-Pumping ATPase

    V. Conclusions and Perspectives


    Adrenergic Control of Phosphofructokinase and Glycolysis in Rat Heart

    I. Introduction

    II. Adrenergic Regulation of PFK in Liver and Muscle

    III. Properties of the Epinephrine-Activated Form of Heart PFK

    IV. Adrenergic Receptors Involved in the Activation of Heart PFK

    V. Molecular Mechanisms

    VI. Deactivase

    VII. The Role of Adrenergic Control of PFK in Cardiac Glycolysis

    VIII. Obesity and the Adrenergic Regulation of Cardiac PFK and Glucose Metabolism

    IX. The Functional Significance of Adrenergic Control of PFK and Glucose Uptake


    Regulation of ATP-Mg-Dependent Protein Phosphatase

    I. Introduction

    II. Protein Kinases and Phosphatases in Glycogen Metabolism

    III. Protein Components Involved in the Regulation of the Multisubstrate Protein Phosphatase

    IV. Characterization of the ATP-Mg-Dependent Multisubstrate Protein Phosphatase

    V. Integration of Protein Phosphatase Activity in the Hormonal and Metabolic Regulation of Glycogen Metabolism

    VI. Concluding Remarks


    Transport and Regulation of Polypeptide Precursors of Mature Mitochondrial Proteins

    I. Introduction

    II. The Dual Origin of Mitochondrial Proteins

    III. Protein Transport Across Membranes in Biological Systems

    IV. Protein Transport from Cytosol to Mitochondria

    V. Enzymatic Activity of Protein Precursors

    VI. Concluding Remarks



    Cumulative Contributors Index

    Contents of Previous Volumes

Product details

  • No. of pages: 278
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: February 1, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9781483217222

About the Editors

Bernard L. Horecker

Earl R. Stadtman

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