Current Topics in Cellular Regulation

Current Topics in Cellular Regulation

1st Edition - April 28, 1983

Write a review

  • Editors: Bernard L. Horecker, Earl R. Stadtman
  • eBook ISBN: 9781483217215

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Current Topics in Cellular Regulation: Volume 22 is a collection of papers that deals with eukaryotic protein synthesis, lysosomal thiol proteinases, and the properties of adenylosuccinate synthetase. Other papers discuss the regulation of acetyl-CoA carboxylase, ornithine cycle, and seminal vesicle development and function. One paper investigates the poly ADP-ribosylation of protein, particularly in quantifying synthesis and in the function of the polymer. Another paper observes the construction of a reconstituted cell-free system in which there is for the first time a catalytic use, followed by a recycling of eIF-2. A eukaryotic regulatory factor or eukaryotic recycling factor (eRF) is a prerequisite factor in the in the control of the rate of initiation. One paper reviews the properties, structures, and functions of thiol endopeptidases in mammalian lysosomes and the characteristics of the endogenous inhibitor. Another paper explains the regulatory, kinetic, and genetic aspects of adenylosuccinate synthetase from a variety of systems. One paper discusses the short-term regulation of the carboxylase from animal tissues, with emphasis on the covalent modification of the carboxylase, and its relationship to the allosteric control mechanism. Molecular biologists, general biologists, and microbiologists will find the articles in this collection invaluable.

Table of Contents

  • Contributors

    Poly ADP-Ribosylation of Protein

    I. Perspectives and Summary

    II. Poly(ADP-Ribose): Historical Aspects and Characterization

    III. Quantification of Poly(ADP-Ribose)

    IV. Poly(ADP-Ribose) Synthetase

    V. Degradation of Poly(ADP-Ribose)

    VI. Physiological Functions of Poly(ADP-Ribose)


    The Control of the Rate of Initiation of Eukaryotic Protein Synthesis

    I. Introduction

    II. Purification and Characterization

    III. The Mode of Action of the Regulatory Factor, eRF

    IV. The Effect of HRI

    V. Complex Formation Between eIF-2 and eRF

    VI. Discussion


    Structures and Functions of Lysosomal Thiol Proteinases and Their Endogenous Inhibitor

    I. Introduction

    II. Properties of Lysosomal Thiol Proteinases

    III. Structures of Lysosomal Thiol Proteinases

    IV. Control of Lysosomal Thiol Proteinases

    V. Endogenous Thiol Proteinase Inhibitor

    VI. Functions of Lysosomal Thiol Proteinases

    VII. Concluding Remarks


    Regulation, Genetics, and Properties of Adenylosuccinate Synthetase: A Review

    I. Introduction

    II. Measurement of Enzyme Activity

    III. Isolation and Properties

    IV The Isozymes of Adenylosuccinate Synthetase

    V. Substrate Specificity

    VI. Inhibitors

    VII. Mechanism of Action

    VIII. Adenylosuccinate Synthetase Regulation in E. coli

    IX. Regulation and Metabolic Roles of Eukaryotic Adenylosuccinate Synthetase

    X. Genetic Considerations


    Regulation of Acetyl-CoA Carboxylase

    I. Introduction

    II. Allosteric Control Mechanism

    III. Covalent Modification Mechanism

    IV. Relationship Between Covalent Phosphorylation and the Quaternary Structure of Acetyl-CoA Carboxylase

    V. Regulation of Covalent Phosphorylation of Acetyl-CoA

    VI. Concluding Remarks


    The Evolutionary History of the Ornithine Cycle as a Determinant of Its Structure and Regulation

    I. Introduction

    II. Problematical Aspects of the Ornithine Cycle

    III. Evolutionary Origin of the Ornithine Cycle

    IV. Evaluation of the Postulated Evolutionary Relationships

    V. Conclusion


    Regulatory Features of Seminal Vesicle Development and Function

    I. Introduction

    II. Occurrence and Functions of Seminal Vesicles

    III. Male Reproductive Tract Differentiation and the Molecular Biology of Steroid Hormone Action

    IV. Embryonic Differentiation of Seminal Vesicles

    V Hormonal Regulation of Adult Seminal Vesicle Growth and Secretory Functions

    VI. Formation and Functions of Vesicular Secretion Constituents

    VII. Participation of Vesicular Secretion Constituents in Semen Coagulation



    Cumulative Contributors Index

    Contents of Previous Volumes

Product details

  • No. of pages: 304
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: April 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9781483217215

About the Editors

Bernard L. Horecker

Earl R. Stadtman

Ratings and Reviews

Write a review

There are currently no reviews for "Current Topics in Cellular Regulation"