Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528225, 9781483217215

Current Topics in Cellular Regulation, Volume 22

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217215
Imprint: Academic Press
Published Date: 28th April 1983
Page Count: 304
Sales tax will be calculated at check-out Price includes VAT/GST
54.95
72.95
43.99
Unavailable
Price includes VAT/GST
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents


Contributors


Poly ADP-Ribosylation of Protein


I. Perspectives and Summary


II. Poly(ADP-Ribose): Historical Aspects and Characterization


III. Quantification of Poly(ADP-Ribose)


IV. Poly(ADP-Ribose) Synthetase


V. Degradation of Poly(ADP-Ribose)


VI. Physiological Functions of Poly(ADP-Ribose)


References


The Control of the Rate of Initiation of Eukaryotic Protein Synthesis


I. Introduction


II. Purification and Characterization


III. The Mode of Action of the Regulatory Factor, eRF


IV. The Effect of HRI


V. Complex Formation Between eIF-2 and eRF


VI. Discussion


References


Structures and Functions of Lysosomal Thiol Proteinases and Their Endogenous Inhibitor


I. Introduction


II. Properties of Lysosomal Thiol Proteinases


III. Structures of Lysosomal Thiol Proteinases


IV. Control of Lysosomal Thiol Proteinases


V. Endogenous Thiol Proteinase Inhibitor


VI. Functions of Lysosomal Thiol Proteinases


VII. Concluding Remarks


References


Regulation, Genetics, and Properties of Adenylosuccinate Synthetase: A Review


I. Introduction


II. Measurement of Enzyme Activity


III. Isolation and Properties


IV The Isozymes of Adenylosuccinate Synthetase


V. Substrate Specificity


VI. Inhibitors


VII. Mechanism of Action


VIII. Adenylosuccinate Synthetase Regulation in E. coli


IX. Regulation and Metabolic Roles of Eukaryotic Adenylosuccinate Synthetase


X. Genetic Considerations


References


Regulation of Acetyl-CoA Carboxylase


I. Introduction


II. Allosteric Control Mechanism</BR


Description

Current Topics in Cellular Regulation: Volume 22 is a collection of papers that deals with eukaryotic protein synthesis, lysosomal thiol proteinases, and the properties of adenylosuccinate synthetase. Other papers discuss the regulation of acetyl-CoA carboxylase, ornithine cycle, and seminal vesicle development and function. One paper investigates the poly ADP-ribosylation of protein, particularly in quantifying synthesis and in the function of the polymer. Another paper observes the construction of a reconstituted cell-free system in which there is for the first time a catalytic use, followed by a recycling of eIF-2. A eukaryotic regulatory factor or eukaryotic recycling factor (eRF) is a prerequisite factor in the in the control of the rate of initiation. One paper reviews the properties, structures, and functions of thiol endopeptidases in mammalian lysosomes and the characteristics of the endogenous inhibitor. Another paper explains the regulatory, kinetic, and genetic aspects of adenylosuccinate synthetase from a variety of systems. One paper discusses the short-term regulation of the carboxylase from animal tissues, with emphasis on the covalent modification of the carboxylase, and its relationship to the allosteric control mechanism. Molecular biologists, general biologists, and microbiologists will find the articles in this collection invaluable.


Details

No. of pages:
304
Language:
English
Copyright:
© Academic Press 1983
Published:
Imprint:
Academic Press
eBook ISBN:
9781483217215

Ratings and Reviews


About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor