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Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528157, 9781483217147

Current Topics in Cellular Regulation, Volume 15

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217147
Imprint: Academic Press
Published Date: 28th December 1979
Page Count: 342
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Table of Contents

List of Contributors

Guanosine 3′,5′-Monophosphate-Dependent Protein Kinase

I. Introduction

II. Structure and Regulation of G-Kinase

III. Kinetics and Thermodynamics of cGMP Binding to G-Kinase

IV. G-Kinase Activity

V. A Hypothesis Concerning the Structures of G-Kinase and A-Kinase


Calmodulin and Its Role in the Second-Messenger System

I. Introduction

II. General Background

III. Activation of Cyclic Nucleotide Phosphodiesterase

IV. Other Regulatory Activities

V. Physiological Roles

VI. Evolutionary Studies


Phosphofructokinase: Structure and Function

I. Introduction

II. Structural Properties

III. Polymeric Forms of Phosphofructokinase

IV. Ligand Binding to Phosphofructokinase

V. Allosteric Kinetics

VI. Cold Lability of Rabbit Muscle Phosphofructokinase

VII. Mechanism of the Reaction

VIII. Enzyme Modification

IX. Ligand-Induced Conformational Changes

X. Alternative Modes of Enzyme Regulation


Genetic Control of Pentose Phosphate Pathway Enzymes in Drosophila

I. Introduction

II. The Pathway

III. The Structural Genes

IV. Genetic Regulatory Effects

V. Metabolic Regulatory Effects

VI. Concluding Remarks


The Regulation and Function of Ornithine Decarboxylase and of the Polyamines

I. Introduction

II. Discrepancies in the Interpretation of the ODC Assay

III. Functions of Polyamines

IV The "Metabolic State" of the Cell and the "External Setting V. The Experimental Systems

VI. Mechanisms That Alter ODC Activity

VII. The Dynamic State of Polyamines in the Normal and Pathologic State

VIII. An Overview of ODC Regulation

IX. Concluding Remarks


Biochemistry of Phagocyte Chemotaxis

I. Introduction

II. Comparison of Chemotaxis in Leukocytes and Other Cells

III. Assay of Chemotaxis

IV. The Chemoattractants: Sensing the Signal

V. Transduction of the Chemotactic Signal

VI. Effector Processes: Sustained Locomotion

VII. Concluding Remarks


Biochemical Aspects of Neurosecretion: Neurophysin-Neurohypophyseal Hormone Complexes

I. Introduction

II. Neurohormones and Neurophysins: Structural Features

III. Neurophysin-Neurohormone Complexes—In Vitro Studies

IV. Neurophysin-Neurohormone Complexes—In Vivo Studies

V. Concluding Remarks


Subject Index

Correction to Volume 9

Contents of Previous Volumes


Current Topics in Cellular Regulation, Volume 15 deliberates the basic mechanisms involved in the regulation of diverse cellular activities.

This book discusses the kinetics and thermodynamics of cGMP binding to G-kinase, activation of cyclic nucleotide phosphodiesterase, and polymeric forms of phosphofructokinase. The genetic control of pentose phosphate pathway enzymes in drosophila, discrepancies in the interpretation of the ODC assay, and comparison of chemotaxis in leukocytes and other cells are also elaborated. This publication likewise covers the biochemical aspects of neurosecretion and neurophysin-neurohormone complexes.

This volume is valuable to biologists and researchers concerned with advances in the general area of cellular regulation.


No. of pages:
© Academic Press 1979
28th December 1979
Academic Press
eBook ISBN:

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About the Editors

Bernard L. Horecker

Earl R. Stadtman