Current Topics in Cellular Regulation

Current Topics in Cellular Regulation

1st Edition - June 28, 1978

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  • Editors: Bernard L. Horecker, Earl R. Stadtman
  • eBook ISBN: 9781483217123

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Current Topics in Cellular Regulation, Volume 13 emphasizes the basic mechanisms involved in the regulation of diverse cellular activities. This book discusses the enzymology of aminoacyl-tRNA protein transferases, analysis of mutant phenotypes, and protein kinase reaction with pyruvate kinase as substrate. The rapid hormonal regulation of pyruvate kinase in vivo, interconvertible enzyme cascades in metabolic regulation, monocyclic cascade systems, and metabolism of fructose in the liver are also elaborated. This publication likewise covers the influence of fructose on lipid metabolism, lactose operator-repressor interaction, and regulation of nitrogenase synthesis. Other topics include the involvement of isozymes in metabolic regulation and molecular approach to the complement system. This volume is a good reference for biologists and researchers conducting work on the advances in the general area of cellular regulation.

Table of Contents

  • Contents

    List of Contributors

    Posttranslational NH2-Terminal Aminoacylation

    I. Introduction

    II. Enzymology of Aminoacyl-tRNA Protein Transferases

    III. Analysis of Acceptor Proteins

    IV. Analysis of Mutant Phenotypes

    V. Discussion

    Note Added in Proof


    The Regulation of Liver Pyruvate Kinase by Phosphorylation-Dephosphorylation

    I. Introduction

    II. Purification and Some Properties of Liver Pyruvate Kinase

    III. Phosphorylation of Liver Pyruvate Kinase in Vitro and Its Effect on the Kinetic Properties of the Enzyme

    IV. Phosphorylated Site of Pig Liver Pyruvate Kinase. Subtilisin-Catalyzed Modification

    V. The Protein Kinase Reaction with Pyruvate Kinase as Substrate

    VI. Phosphorylation of Peptides with Structures Related to the Phosphorylatable Site of Pyruvate Kinase

    VII. Dephosphorylation of Pyruvate Kinase with Phosphoprotein Phosphatase

    VIII. Rapid Hormonal Regulation of Pyruvate Kinase in Vivo

    IX. Conclusions


    Interconvertible Enzyme Cascades in Metabolic Regulation

    I. Introduction

    II. Monocyclic Cascade Systems

    III. Bicyclic Cascade Systems

    IV. Multicyclic Cascade Systems

    V. Discussion


    Metabolic Effects of Fructose in the Liver

    I. Introduction

    II. Metabolism of Fructose in the Liver

    III. Influence of Fructose on the Metabolism of Glycogen

    IV. Effect of Fructose on the Catabolism of Purine Nucleotides

    V. Influence of Fructose on Lipid Metabolism

    VI. Effect of Fructose on Alcohol Metabolism

    VII. Concluding Remarks


    Lactose Operator-Repressor Interaction

    I. Introduction

    II. The Lac Repressor

    III. The Lac Operator

    IV. Lactose Operator-Repressor Interaction

    V. Models for the Operator-Repressor Interaction and Concluding



    Regulation of Nitrogen Fixation

    I. Introduction

    II. Regulation of Nitrogenase Activity

    III. Regulation of Nitrogenase Synthesis

    IV Electron Transport and ATP Production Coupled to N2 Reduction

    V. Other Related Regulation

    VI. Synopsis


    The Role of Isozymes in Metabolism: A Model of Metabolic Pathways as the Basis for the Biological Role of Isozymes

    I. Introduction

    II. The Involvement of Isozymes in Metabolic Regulation

    III. The Role of Compartmentation in Metabolic Regulation

    IV. A Hypothetical Model of Metabolism: Polyisozymic Complexes

    V. Polyisozymic Complexes in Glucose Utilization

    VI. Suggested Experimental Tests of the Hypothesis

    VII. Concluding Remarks


    A Molecular Approach to the Complement System

    I. Introduction

    II. The Complement System

    III. Individual Components

    IV. Mechanisms of Action

    V. Comparisons of Structure and Function

    VI. Conclusions and Comments


    Subject Index

    Contents of Previous Volumes

Product details

  • No. of pages: 334
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: June 28, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9781483217123

About the Editors

Bernard L. Horecker

Earl R. Stadtman

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