Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528133, 9781483217123

Current Topics in Cellular Regulation, Volume 13

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217123
Imprint: Academic Press
Published Date: 28th June 1978
Page Count: 334
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Table of Contents


List of Contributors

Posttranslational NH2-Terminal Aminoacylation

I. Introduction

II. Enzymology of Aminoacyl-tRNA Protein Transferases

III. Analysis of Acceptor Proteins

IV. Analysis of Mutant Phenotypes

V. Discussion

Note Added in Proof


The Regulation of Liver Pyruvate Kinase by Phosphorylation-Dephosphorylation

I. Introduction

II. Purification and Some Properties of Liver Pyruvate Kinase

III. Phosphorylation of Liver Pyruvate Kinase in Vitro and Its Effect on the Kinetic Properties of the Enzyme

IV. Phosphorylated Site of Pig Liver Pyruvate Kinase. Subtilisin-Catalyzed Modification

V. The Protein Kinase Reaction with Pyruvate Kinase as Substrate

VI. Phosphorylation of Peptides with Structures Related to the Phosphorylatable Site of Pyruvate Kinase

VII. Dephosphorylation of Pyruvate Kinase with Phosphoprotein Phosphatase

VIII. Rapid Hormonal Regulation of Pyruvate Kinase in Vivo

IX. Conclusions


Interconvertible Enzyme Cascades in Metabolic Regulation

I. Introduction

II. Monocyclic Cascade Systems

III. Bicyclic Cascade Systems

IV. Multicyclic Cascade Systems

V. Discussion


Metabolic Effects of Fructose in the Liver

I. Introduction

II. Metabolism of Fructose in the Liver

III. Influence of Fructose on the Metabolism of Glycogen

IV. Effect of Fructose on the Catabolism of Purine Nucleotides

V. Influence of Fructose on Lipid Metabolism

VI. Effect of Fructose on Alcohol Metabolism

VII. Concluding Remarks


Lactose Operator-Repressor Interaction

I. Introduction

II. The Lac Repressor

III. The Lac Operator

IV. Lactose Operator-Repressor Interaction

V. Models for the Operator-Repressor Interaction and Concluding



Regulation of Nitrogen Fixation

I. Introduction

II. Regulation of Nitrogenase Activity

III. Regulation of Nitrogenase Synthesis

IV Electron Transport and ATP Production Coupled to N2 Reduction

V. Other Related Regulation

VI. Synopsis


The Role of Isozymes in Metabolism: A Model of Metabolic Pathways as the Basis for the Biological Role of Isozymes

I. Introduction

II. The Involvement of Isozymes in Metabolic Regulation

III. The Role of Compartmentation in Metabolic Regulation

IV. A Hypothetical Model of Metabolism: Polyisozymic Complexes

V. Polyisozymic Complexes in Glucose Utilization

VI. Suggested Experimental Tests of the Hypothesis

VII. Concluding Remarks


A Molecular Approach to the Complement System

I. Introduction

II. The Complement System

III. Individual Components

IV. Mechanisms of Action

V. Comparisons of Structure and Function

VI. Conclusions and Comments


Subject Index

Contents of Previous Volumes


Current Topics in Cellular Regulation, Volume 13 emphasizes the basic mechanisms involved in the regulation of diverse cellular activities.

This book discusses the enzymology of aminoacyl-tRNA protein transferases, analysis of mutant phenotypes, and protein kinase reaction with pyruvate kinase as substrate. The rapid hormonal regulation of pyruvate kinase in vivo, interconvertible enzyme cascades in metabolic regulation, monocyclic cascade systems, and metabolism of fructose in the liver are also elaborated. This publication likewise covers the influence of fructose on lipid metabolism, lactose operator-repressor interaction, and regulation of nitrogenase synthesis. Other topics include the involvement of isozymes in metabolic regulation and molecular approach to the complement system.

This volume is a good reference for biologists and researchers conducting work on the advances in the general area of cellular regulation.


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© Academic Press 1978
Academic Press
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About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor