Current Topics in Cellular Regulation - 1st Edition - ISBN: 9780121528133, 9781483217123

Current Topics in Cellular Regulation, Volume 13

1st Edition

Editors: Bernard L. Horecker Earl R. Stadtman
eBook ISBN: 9781483217123
Imprint: Academic Press
Published Date: 28th June 1978
Page Count: 334
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Table of Contents


List of Contributors

Posttranslational NH2-Terminal Aminoacylation

I. Introduction

II. Enzymology of Aminoacyl-tRNA Protein Transferases

III. Analysis of Acceptor Proteins

IV. Analysis of Mutant Phenotypes

V. Discussion

Note Added in Proof


The Regulation of Liver Pyruvate Kinase by Phosphorylation-Dephosphorylation

I. Introduction

II. Purification and Some Properties of Liver Pyruvate Kinase

III. Phosphorylation of Liver Pyruvate Kinase in Vitro and Its Effect on the Kinetic Properties of the Enzyme

IV. Phosphorylated Site of Pig Liver Pyruvate Kinase. Subtilisin-Catalyzed Modification

V. The Protein Kinase Reaction with Pyruvate Kinase as Substrate

VI. Phosphorylation of Peptides with Structures Related to the Phosphorylatable Site of Pyruvate Kinase

VII. Dephosphorylation of Pyruvate Kinase with Phosphoprotein Phosphatase

VIII. Rapid Hormonal Regulation of Pyruvate Kinase in Vivo

IX. Conclusions


Interconvertible Enzyme Cascades in Metabolic Regulation

I. Introduction

II. Monocyclic Cascade Systems

III. Bicyclic Cascade Systems

IV. Multicyclic Cascade Systems

V. Discussion


Metabolic Effects of Fructose in the Liver

I. Introduction

II. Metabolism of Fructose in the Liver

III. Influence of Fructose on the Metabolism of Glycogen

IV. Effect of Fructose on the Catabolism of Purine Nucleotides

V. Influence of Fructose on Lipid Metabolism

VI. Effect of Fructose on Alcohol Metabolism

VII. Concluding Remarks


Lactose Operator-Repressor Inte


Current Topics in Cellular Regulation, Volume 13 emphasizes the basic mechanisms involved in the regulation of diverse cellular activities.

This book discusses the enzymology of aminoacyl-tRNA protein transferases, analysis of mutant phenotypes, and protein kinase reaction with pyruvate kinase as substrate. The rapid hormonal regulation of pyruvate kinase in vivo, interconvertible enzyme cascades in metabolic regulation, monocyclic cascade systems, and metabolism of fructose in the liver are also elaborated. This publication likewise covers the influence of fructose on lipid metabolism, lactose operator-repressor interaction, and regulation of nitrogenase synthesis. Other topics include the involvement of isozymes in metabolic regulation and molecular approach to the complement system.

This volume is a good reference for biologists and researchers conducting work on the advances in the general area of cellular regulation.


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© Academic Press 1978
Academic Press
eBook ISBN:

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About the Editors

Bernard L. Horecker Editor

Earl R. Stadtman Editor