Current Topics in Cellular Regulation

Current Topics in Cellular Regulation

1st Edition - December 28, 1972

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  • Editors: Bernard L. Horecker, Earl R. Stadtman
  • eBook ISBN: 9781483217055

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Description

Current Topics in Cellular Regulation, Volume 6 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into eight chapters, this volume begins with an overview of the well-defined stages of sporulation that can be correlated with the appearance of several enzymes, ultrastructures, and chemical components associated with the developing spore. This text then examines the regulatory properties of G6PD from various sources, with emphasis to those cells in which these properties may operate in vivo in the control of carbohydrate metabolism. Other chapters consider the various methods for analyzing biochemical systems. The final chapter deals with kinetic cooperativity, which is the basis of the flip-flop mechanism. This book is a valuable resource for biochemists, biologists, and research workers.

Table of Contents


  • List of Contributors

    Preface

    Preface to Volume 6

    Contents of Previous Volumes

    Role of Proteases in Sporulation

    I. Introduction

    II. Extracellular Proteases of Bacilli

    III. Regulation of Extracellular Protease Synthesis and Sporulation

    IV. Protein Turnover during Sporulation

    V. The Modification of RNA Polymerase and Aldolase by a Serine Protease

    VI. Conclusions

    References

    Regulatory Properties of Glucose-6-Phosphate Dehydrogenase

    I. Introduction

    II. General Properties

    III. G6PD from Microorganisms

    IV. G6PD from Mammalian Cells

    V. Concluding Remarks

    References

    The Behavior of Intact Biochemical Control Systems

    I. Introduction

    II. Essential Concepts and Techniques Illustrated by the Analysis of a Simple System

    III. Natural Selection of Feedback Inhibition Patterns in Biosynthetic Pathways

    IV. On the Significance of Feedforward Inhibition in a Biosynthetic Pathway

    V. Cascaded Enzymatic Mechanisms

    VI. Summary

    References

    A Possible Role for Kinetic Reaction Mechanism Dependent Substrate and Product Effects in Enzyme Regulation

    I. Introduction

    II. Product Effects on Enzyme Velocity Responses

    III. Product Effects on Cooperative Substrate Binding

    IV. Substrate Effects on Enzyme Velocity Responses

    V. Simulations and Observations with Actual Systems

    VI. Michaelis Constants

    VII. Evaluation and Future Developments

    References

    Control of Biogenesis of Isoprenoid Compounds in Animals

    I. The Pathways of Biogenesis

    II. Cholesterol

    III. Ubiquinone

    IV. Bile Acids

    V. Steroid Hormones

    VI. Concluding Remarks

    References

    On Allosteric Models

    I. Some General Relations

    II. A Parent Model

    III. The MWC and Induced-Fit Models as Subcases

    IV. The Effect of a Second Ligand

    V. The Effect of Subunit Heterogeneity

    VI. An Example from Trout Hemoglobin

    VII. Conclusion

    References

    Regulation of Uridylic Acid Biosynthesis in Eukaryotic Cells

    I. General Pathway for Uridylic Acid Biosynthesis

    II. Genetic Control of Enzyme Levels in Fungi

    III. The Eukaryotic Enzymes

    References

    Flip-Flop Mechanisms and Half-Site Enzymes

    I. Introduction

    II. The Flip-Flop Mechanism. Description of a Model, the Alkaline Phosphatase of Eschenchia coli

    III. Half-Site Enzymes

    IV. Half-of-the-Sites Reactivity and Flip-Flop Mechanisms for Allosteric Enzymes

    V. The Functional and Evolutionary Advantages of Half-Site Enzymes and Flip-Flop Mechanisms

    References

    Note Added in Proof

    Author Index

    Subject Index

Product details

  • No. of pages: 352
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: December 28, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9781483217055

About the Editors

Bernard L. Horecker

Earl R. Stadtman

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