Current Topics in Bioenergetics

Current Topics in Bioenergetics

Structure, Biogenesis, and Assembly of Energy Transducing Enzyme Systems

1st Edition - November 19, 1987

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  • Editor: C. P. Lee
  • eBook ISBN: 9781483216997

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Current Topics in Bioenergetics, Volume 15: Structure, Biogenesis, and Assembly of Energy Transducing Enzyme Systems presents the reaction mechanisms involved in membrane-associated energy transducing processes at the molecular level. This book discusses the developments in the energy transducing systems. Organized into 11 chapters, this volume begins with an overview of the composition and structural aspects of the four respiratory chain complexes. This text then discusses the genetic aspects of various energy transducing systems. Other chapters consider the electron transfer chains of chloroplast, mitochondria, and some photosynthetic bacteria, which contain a multiprotein complex with similar functional and structural properties. This book discusses as well the structure and function of multiple and variable amounts of subunits in cytochrome-c oxidase from various organisms. The final chapter deals with the interdisciplinary path of bioenergetics, with the center of gravity moving from chemistry through genetics to physics. This book is a valuable resource for biologists.

Table of Contents

  • Preface

    Structure of NADH-Ubiquinone Reductase (Complex I)

    I. Introduction

    II. Catalytic Properties

    III. Monomer or Dimer

    IV. The Polypeptide Composition

    V. Fragmentation of the Enzyme

    VI. Structural Studies Using Hydrophilic and Hydrophobic Probes

    VII. The Structure of the Enzyme and Its Relationship to Mechanism


    Structure of the Succinate-Ubiquinone Oxidoreductase (Complex II)

    I. Introduction

    II. Iron-Sulfur Clusters of Succinate Dehydrogenase

    III. Cytochrome b of the Succinate-UQ Reductase

    IV. Concluding Remarks


    Structure of Mitochondrial Ubiquinol-Cytochrome-c Reductase (Complex III)

    I. Introduction

    II. Isolation and Molecular Weight

    III. Structural Features of Subunits

    IV. Three-Dimensional Structure

    V. Topography of Subunits

    VI. Structure-Function Relationship

    VII. Summary


    Structure of Cytochrome-c Oxidase

    I. Introduction

    II. Size and Shape of of the Bovine Heart Cytochrome-c Oxidase

    III. Aggregation State in Relation to Function

    IV. Prosthetic Groups

    V. Subunit Structure

    VI. Arrangement of Polypeptides in the Cytochrome-c Oxidase Complex

    VII. Identification of Apoproteins for the Redox Centers

    VIII. Proton Pumping and Subunit MtIII

    IX. Cytochrome c Binding Sites and Subunit MtII

    X. Role of the Cytoplasmically Synthesized Polypeptides in Cytochrome-c Oxidase Activity


    Evolution of a Regulatory Enzyme: Cytochrome-c Oxidase (Complex IV)

    I. Introduction

    II. Role of Cytochrome-c Oxidase in Energy Metabolism

    III. Catalytic Cofactors and Role of Lipids

    IV. Biosynthesis and Assembly

    V. Subunit Composition

    VI. Tissue-Specific Isozymes

    VII. Amino Acid Sequences

    VIII. Structure and Membrane Orientation

    IX. Binding Domains

    X. Kinetics

    XI. Proton Translocation

    XII. Regulatory Function of Subunits

    XIII. Evolution of Cytochrome-c Oxidase


    The Assembly of F1F0-ATPase in Escherichia coli

    I. Introduction

    II. Assembly of the b Subunit into a Functional F0

    III. Proton-Impermeable F0 Sectors Resulting from Mutant F1-ATPase Subunits

    IV. Assembly of F0 Subunits in Genetically Engineered Strains

    V. Summary


    Biogenesis of Mitochondrial Energy Transducing Complexes

    I. Introduction

    II. Biogenesis of Nuclear-Coded Mitochondrial Proteins

    III. Biogenesis of Proteins Coded by Mitochondrial Genes

    IV. Coordination Between Cytoplasmic and Mitochondrial Protein Synthesis

    V. Assembly of Protein Complexes

    VI. Biogenesis Pathways

    VII. Perspectives


    Biogenesis of Mammalian Mitochondria

    I. The Mitochondrial Genome

    II. Mitochondrial Proteins Encoded in the Nucleus

    III. Nuclear and Mitochondrial Interactions

    IV. Mitochondria and Disease


    Structure and Biogenesis of Chloroplast Coupling Factor CF0CF1-ATPase

    I. Introduction

    II. Structure of the Chloroplast ATPase

    III. Biogenesis of the Proton-ATPase Complex

    IV. Future Directions


    Mitochondrial Gene Products

    I. Introduction

    II. Ribosomal RNAs

    III. Transfer RNAs

    IV. Proteins

    V. Other Gene Products

    VI. Conclusions and Perspectives


    Overview: Bioenergetics Between Chemistry, Genetics, and Physics

    I. Introduction

    II. Proteins Are Molecular Engines

    III. How Engines Evolved

    IV. How Engines are Assembled

    V. How Engines are Maintained

    VI. Future Prospects: Bioenergetics Beyond Chemistry, Genetics, and Physics



    Contents of Previous Volumes

Product details

  • No. of pages: 402
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: November 19, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9781483216997

About the Editor

C. P. Lee

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