Current Topics in Bioenergetics

Current Topics in Bioenergetics

Volume 14

1st Edition - July 28, 1985

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  • Editor: C. P. Lee
  • eBook ISBN: 9781483216980

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Current Topics in Bioenergetics, Volume 14 provides information pertinent to the structure and function relationship of energy-transducing membranes. This book presents a number of biochemical and biophysical approaches that are valuable in some systems. Organized into five chapters, this volume begins with an overview of cytochrome oxidase, a noncrystallizable membrane protein. This text then determines the interaction of small organic molecules with biological membranes on a molecular level. Other chapters consider the various physical techniques that are used to investigate the structural and dynamic properties of proteins, lipids, and membranes, including neutron diffraction, X-ray diffraction, electron microscopy, optical rotatory dispersion, nuclear magnetic resonance, fluorescence spectroscopy, and Raman spectroscopy. This book discusses as well the biological importance of metal ions. The final chapter deals with optical activity spectroscopy as a recognized tool for the examination of the conformation of biological macromolecules. This book is a valuable resource for biochemists, biophysicists, and biologists.

Table of Contents

  • Contributors


    Contents of Previous Volumes

    Structure of Cytochrome Oxidase Redox Centers in Native and Modified Forms: An EXAFS Study

    I. Introduction

    II. General Background

    III. EXAFS Studies on the Resting Enzyme

    IV. Cu EXAFS

    V. Fe EXAFS

    VI. EXAFS Study on the Pulsed Oxidase

    VII. Chemical Studies

    VIII. The Active Site of Cytochrome Oxidase in Its Resting (S-Bridged) and Pulsed (Nonbridged) Forms

    IX. Summary


    X-Ray and Neutron Diffraction for Probing the Interactions of Small Molecules with Membrane Structures

    I. Overview

    II. Small Molecule-Membrane Systems Employed

    III. Neutron Diffraction Approach

    IV. X-Ray Diffraction Approach

    V. Drug "Conformation" and Orientation in Biological Membranes

    VI. Molecular Model for Drug Binding to Cardiac Sarcolemmal Receptors

    VII. Conclusions


    19F NMR Investigations of Membranes

    I. Introduction

    II. Types of Nuclei Used in Membrane Studies by NMR

    III. Theoretical Aspects of 19F NMR as Applied to Membrane Systems

    IV. 19F NMR Studies of Model Membrane Systems

    V. 19F NMR Studies of Bacterial Membrane Lipids

    VI. A Strategy For Investigating Protein-Lipid Interactions in Membranes Using 19F NMR

    VII. Perturbations Produced by Substituting 19F Atoms for 1H Atoms in Membrane Lipids and Proteins

    VIII. Summary


    Metal Ion NMR: Application to Biological Systems

    I. Introduction

    II. Theory

    III. Applications


    Circular Dichroism Studies of Electron-Transport Components

    I. Introduction

    II. Methodology

    III. Intrinsic Circular Dichroism Spectra

    IV. Extrinsic Circular Dichroism Spectra



Product details

  • No. of pages: 208
  • Language: English
  • Copyright: © Academic Press 1985
  • Published: July 28, 1985
  • Imprint: Academic Press
  • eBook ISBN: 9781483216980

About the Editor

C. P. Lee

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