Current Concepts in Drug Metabolism and Toxicology

Current Concepts in Drug Metabolism and Toxicology

1st Edition - June 12, 2012

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  • Editor: Gabrielle M. Hawksworth
  • Hardcover ISBN: 9780123983398
  • eBook ISBN: 9780123983596

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Description

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Key Features

  • Explores the current concepts in drug metabolism and toxicology
  • Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity
  • An essential resource for pharmacologists, immunologists and biochemists alike

Readership

Pharmacologists, immunologists, and biochemists

Table of Contents

  • Contributors

    Membrane Transporters in Drug Development

    I Introduction

    II Key Features of Transporters

    III Transporters and the Pharmaceutical Industry

    IV Studying and Contextualizing Transporter Interactions: Application and Interpretation of Data

    V The Transporter Toolkit, its Opportunities and Challenges

    VI Conclusion

    Acknowledgments

    Abbreviations

    The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?

    I Introduction

    II The Keap1–Nrf2 Cell Defense Pathway

    III Activation of Nrf2 as a Potential Therapeutic Strategy

    IV Inhibition of Nrf2 as a Potential Therapeutic Strategy

    V Conclusion

    Abbreviations

    Animal Models of Idiosyncratic Drug Reactions

    I Introduction

    II Animal Models of Skin Rash

    III Animal Models of Liver Toxicity

    IV Animal Models of Hematological Toxicity

    V Animal Models of Generalized Hypersensitivity Reactions

    VI Animal Models of Generalized Autoimmunity

    VII Conclusion

    Abbreviations

    Genetic Polymorphisms Affecting Drug Metabolism

    I Introduction

    II Recent Advances in the Pharmacogenetics of Cytochromes P450

    III Recent Advances in the Pharmacogenetics of Non-P450 Metabolism

    IV Clinical Relevance of Polymorphic Metabolism – Some Contemporary Examples

    V Conclusion

    Abbreviations

    Arylamine N-Acetyltransferases – from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention

    I Introduction

    II NAT Enzyme Mechanism

    III NAT Genes and Pharmacogenetics

    IV The Genomic Distribution and Function of NATs

    V NAT Gene Expression and Regulation

    VI Development of NAT Inhibitors

    VII Conclusion

    Abbreviations

    Human Pluripotent Stem Cells for Modeling Toxicity

    I Introduction

    II The Use of Human Stem Cells in Developmental Toxicity

    III The Use of Human Stem Cells in Cardiotoxicity

    IV The Use of Human Stem Cells in Hepatotoxicity

    V The Use of Human Stem Cells in Neurotoxicity

    VI Conclusion

    Abbreviations

    Disposition of Biologics

    I Introduction

    II Routes of Administration

    III Mechanisms of Biologics Distribution and Clearance, The Importance of Active Processes

    IV Distribution Studies with Biologics and Relevance to Toxicology Studies

    V Metabolism of Biologics

    VI Consideration of Immunogenicity – Changes in Disposition and Impact on Toxicology

    VII Conclusion

    Abbreviations

    Index

    Recent Volumes in the Serial

Product details

  • No. of pages: 304
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: June 12, 2012
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123983398
  • eBook ISBN: 9780123983596

About the Serial Volume Editor

Gabrielle M. Hawksworth

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