Description

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Key Features

  • Explores the current concepts in drug metabolism and toxicology
  • Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity
  • An essential resource for pharmacologists, immunologists and biochemists alike

Readership

Pharmacologists, immunologists, and biochemists

Table of Contents

Contributors

Membrane Transporters in Drug Development

I Introduction

II Key Features of Transporters

III Transporters and the Pharmaceutical Industry

IV Studying and Contextualizing Transporter Interactions: Application and Interpretation of Data

V The Transporter Toolkit, its Opportunities and Challenges

VI Conclusion

Acknowledgments

Abbreviations

The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?

I Introduction

II The Keap1–Nrf2 Cell Defense Pathway

III Activation of Nrf2 as a Potential Therapeutic Strategy

IV Inhibition of Nrf2 as a Potential Therapeutic Strategy

V Conclusion

Abbreviations

Animal Models of Idiosyncratic Drug Reactions

I Introduction

II Animal Models of Skin Rash

III Animal Models of Liver Toxicity

IV Animal Models of Hematological Toxicity

V Animal Models of Generalized Hypersensitivity Reactions

VI Animal Models of Generalized Autoimmunity

VII Conclusion

Abbreviations

Genetic Polymorphisms Affecting Drug Metabolism

I Introduction

II Recent Advances in the Pharmacogenetics of Cytochromes P450

III Recent Advances in the Pharmacogenetics of Non-P450 Metabolism

IV Clinical Relevance of Polymorphic Metabolism – Some Contemporary Examples

V Conclusion

Abbreviations

Arylamine N-Acetyltransferases – from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention

I Introduction

II NAT Enzyme Mechanism

III NAT Genes and Pharmacogenetics

IV The Genomic Distribution and Function of NATs

V NAT Gene Expression and Regulation

VI Development of NAT Inhibitors

VII Conclusion

Abbreviations

Human Pluripotent Stem Cells for Modeling Toxicity

Details

No. of pages:
304
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123983596
Print ISBN:
9780123983398

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