For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease.

Key Features

Brought together some of the foremost basic science and clinical researchers.
Part of the renowned Advances in Pharmacology Serial
Discussion of some of the new frontiers in the development of targeted cancer therapy


Pharmacologists, immunologists, and biochemists

Table of Contents

    1. Vertical pathway targeting in cancer therapy
    2. David Shahbazian, Joshua Sznol and Harriet M. Kluger

    3. Histone Deacetylases (HDACs) as Mediators of Resistance to Apoptosis in Melanoma and as Targets for Combination Therapy with Selective BRAF Inhibitors
    4. Fritz Lai, Lei Jin, Stuart Gallagher, Branka Mijatov, Xu Dong Zhang and Peter Hersey

    5. Targeting the tumor stroma as a novel treatment strategy for breast cancer – shifting from the neoplastic cell-centric to a stroma-centric paradigm
    6. Julia Tchou, Jose Conejo-Garcia

    7. Targeting the Metabolic Microenvironment of Tumors
    8. Kate M. Bailey, Jonathan W. Wojtkowiak, Arig Ibrahim Hashim and Robert J. Gillies

    9. Targeted Therapy for Matastasis
    10. Michael A. Davies

    11. Emerging Strategies for Targeting Cell Adhesion in Multiple Myeloma
    12. Rajesh R Nair, Anthony W Gebhard, Michael F Emmons and Lori A Hazlehurst

    13. Targeting Notch Signaling for Cancer Therapeutic Intervention
    14. Hongwei Shao, Qinghua Huang and Zhao-Jun Liu

    15. Stem-like cells and therapy resistance in squamous cell carcinomas
    16. Nicole Facompre, Hiroshi Nakagawa and Meenhard Herlyn, Devraj Basu

    17. Targeting the tumor stroma as a novel therapeutic approach for prostate cancer
    18. Omar E. Franco

    19. Resistance to chemotherapy: short-term drug tolerance and stem cell-like subpopulations
    20. Kevin J. Basile and Andrew E. Aplin

    21. Intratumoral Heterogeneity as a Therapy Resistance Mechanism: Role of Melanoma Subpopulations
    22. Rajasekharan


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© 2012
Academic Press
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